| 1 | Fresno Community Hospital and Medical Center | Health Care | $4.0B | $3.1B |
| 2 | Californias Valued Trust | Unclassified | $1.1B | $196.7M |
| 3 | Saint Agnes Medical Center | Health Care | $651.9M | $635.5M |
| 4 | Central Valley Regional Center INC | Human Services | $630.5M | $331.8M |
| 5 | Community Hospitals of Central California | Health Care | $339.8M | $142.4M |
| 6 | Sante Health Foundation | Health Care | $261.7M | $33.2M |
| 7 | United Health Centers of the San Joaquin Valley | Health Care | $241.4M | $352.1M |
| 8 | Educational Employees Credit Union | Unclassified | $239.3M | $4.7B |
| 9 | Community Health Partners | Health Care | $218.4M | $83.0M |
| 10 | Central California Food Bank | Food, Agriculture & Nutrition | $183.6M | $56.3M |
| 11 | Fresno County Economic Opportunities Commission | Human Services | $158.9M | $40.2M |
| 12 | California State University Fresno Foundation | Education | $118.3M | $368.0M |
| 13 | Fresno Pacific University | Unclassified | $94.5M | $83.6M |
| 14 | California Teaching Fellows Foundation | Unclassified | $72.8M | $12.3M |
| 15 | Saint Agnes Medical Foundation | Health Care | $67.8M | $73.6M |
| 16 | University Faculty Associates INC | Health Care | $51.0M | $6.8M |
| 17 | Kings View | Mental Health & Crisis Intervention | $43.1M | $25.9M |
| 18 | California State University Fresno Athletic Corporation | Unclassified | $42.6M | $14.4M |
| 19 | Yosemite Valley Charter School | Education | $42.2M | $13.2M |
| 20 | California State University Fresno Association INC | Education | $41.5M | $108.8M |
| 21 | Supportive Services INC | Human Services | $36.7M | $23.7M |
| 22 | Central California Blood Center | Health Care | $35.4M | $40.6M |
| 23 | Fresnos Chaffee Zoo Corporation | Animal-Related | $33.4M | $146.8M |
| 24 | American Pistachio Growers | Community Improvement & Capacity Building | $32.8M | $13.5M |
| 25 | Central Valley Community Foundation | Philanthropy, Voluntarism & Grantmaking | $29.9M | $163.1M |
| 26 | California Home for the Aged INC | Health Care | $29.4M | $61.7M |
| 27 | Hinds Hospice | Human Services | $29.0M | $29.6M |
| 28 | Central Valley Childrens Services Network | Human Services | $25.6M | $6.3M |
| 29 | Marjaree Mason Center INC | Human Services | $24.1M | $30.9M |
| 30 | Fresno Area Workforce Investment Corporation | Employment | $24.0M | $6.0M |
| 31 | Valley Teen Ranch | Human Services | $21.6M | $23.1M |
| 32 | Monarch River Academy | Education | $21.0M | $7.3M |
| 33 | Poverello House | Housing & Shelter | $20.2M | $19.6M |
| 34 | Aspen Public Schools INC | Education | $18.2M | $8.7M |
| 35 | Daniel R Martin Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $16.9M | $31.0M |
| 36 | California Health Collaborative | Health Care | $16.7M | $6.6M |
| 37 | Fresno Pacific University Foundation | Education | $15.8M | $22.8M |
| 38 | Agape | Education | $15.5M | $16.8M |
| 39 | Fresno Rescue Mission | Housing & Shelter | $15.4M | $59.3M |
| 40 | State Center Community College Foundation | Unclassified | $14.4M | $31.7M |
| 41 | Central California Legal Services INC | Crime & Legal-Related | $14.4M | $9.4M |
| 42 | Ser-jobs for Progress INC - San Joaquin Valley | Arts, Culture & Humanities | $14.1M | $7.9M |
| 43 | Western Diocese Endowment Fund INC | Religion-Related | $14.0M | $74.1M |
| 44 | The Arc Fresno Madera Counties | Unclassified | $13.3M | $21.4M |
| 45 | Sieg and Doris Fischer Family Foundation | Philanthropy, Voluntarism & Grantmaking | $13.1M | $19.8M |
| 46 | Catholic Charities of the Diocese of Fresno | Human Services | $12.3M | $9.5M |
| 47 | Global Brigades INC | Education | $11.9M | $5.9M |
| 48 | Exceptional Parents Unlimited INC | Human Services | $11.8M | $8.7M |
| 49 | Promesa Behavioral Health | Human Services | $11.8M | $12.4M |
| 50 | Community Hospital of Central California Foundation | Health Care | $11.7M | $44.5M |
| 51 | United Cerebral Palsy Association of Central California INC | Diseases, Disorders & Medical Disciplines | $11.5M | $15.8M |
| 52 | Fresno Deputy Sheriffs & Sheriffs Sgts Assn Insurance Bene Tr Fund | Unclassified | $11.4M | $3.0M |
| 53 | The Fresno Center | Human Services | $11.3M | $5.9M |
| 54 | Alliance for Medical Outreach and Relief | International, Foreign Affairs & National Security | $10.6M | $13.5M |
| 55 | Todos Para la Salud | Health Care | $10.4M | $12.0M |
| 56 | The Economic Development Corporation Serving Fresno County | Unclassified | $10.4M | $5.6M |
| 57 | Elevate Community Services INC | Human Services | $10.2M | $6.6M |
| 58 | Edison Bethune Charter Academy | Education | $10.0M | $15.4M |
| 59 | Quality Group Homes INC | Human Services | $9.8M | $10.2M |
| 60 | Fresno Christian Schools | Education | $9.6M | $8.4M |
| 61 | Persian Heritage Foundation | Unclassified | $9.0M | $10.4M |
| 62 | Big Picture Schools California INC | Education | $9.0M | $4.7M |
| 63 | Shoot the Puck Foundation INC | Recreation & Sports | $8.8M | $6.6M |
| 64 | Centro la Familia Advocacy Services INC | Unclassified | $8.5M | $2.7M |
| 65 | Aims Education Foundation | Education | $8.5M | $36.9M |
| 66 | Roofers Health and Welfare Fund of Central California | Mutual & Membership Benefit | $8.5M | $6.7M |
| 67 | Fresno American Indian Health Project | Health Care | $8.4M | $11.8M |
| 68 | Fort Washington Golf & Country Club | Unclassified | $8.3M | $6.5M |
| 69 | University High School | Education | $7.9M | $6.7M |
| 70 | Sisters of Nazareth of Fresno | Human Services | $7.9M | $5.5M |
| 71 | Greater Fresno Health Organization INC | Health Care | $7.7M | $7.9M |
| 72 | Reading and Beyond | Youth Development | $7.7M | $7.1M |
| 73 | Credit Unions in the State of California | Unclassified | $7.6M | $173.2M |
| 74 | Fansler Foundation | Unclassified | $7.6M | $30.5M |
| 75 | Smittcamp Family Foundation | Unclassified | $7.4M | $14.4M |
| 76 | Central California Asthma Collaborative | Diseases, Disorders & Medical Disciplines | $7.4M | $3.7M |
| 77 | Golden Charter Academy | Education | $7.4M | $6.2M |
| 78 | Leadership Counsel for Justice and Accountability | Civil Rights, Social Action & Advocacy | $7.4M | $19.1M |
| 79 | California-hawaii Elks Major Project INC | Human Services | $7.3M | $96.6M |
| 80 | Girl Scouts of Central California South | Unclassified | $7.3M | $7.7M |
| 81 | Isnardi Foundation | Philanthropy, Voluntarism & Grantmaking | $7.1M | $11.7M |
| 82 | Golden State Family Services INC | Human Services | $7.0M | $3.4M |
| 83 | Boys & Girls Clubs of Fresno County | Youth Development | $6.9M | $15.0M |
| 84 | Fresno State Bulldog Foundation | Education | $6.9M | $13.4M |
| 85 | Sierra Charter School | Education | $6.6M | $5.9M |
| 86 | Fresno Area Hispanic Foundation | Community Improvement & Capacity Building | $6.6M | $13.0M |
| 87 | Comprehensive Youth Services of Fresno INC | Crime & Legal-Related | $6.5M | $1.6M |
| 88 | United Local Credit Union | Unclassified | $6.4M | $121.5M |
| 89 | Kepler Education | Education | $6.2M | $16.8M |
| 90 | San Joaquin Country Club | Unclassified | $6.1M | $13.2M |
| 91 | Silvercrest INC | Housing & Shelter | $6.1M | $30.9M |
| 92 | Building Better Communities Foundation | Food, Agriculture & Nutrition | $5.9M | $4.6M |
| 93 | Education and Leadership Foundation | Education | $5.9M | $7.2M |
| 94 | Central California Environmental Justice Network | Environment | $5.9M | $9.3M |
| 95 | Fresno Community Development Financial Institution | Public & Societal Benefit | $5.9M | $31.9M |
| 96 | Fresno Metropolitan Ministry | Human Services | $5.8M | $4.6M |
| 97 | Agricultural Foundation of California State University Fresno | Unclassified | $5.6M | $6.4M |
| 98 | United Way Fresno and Madera Counties | Unclassified | $5.5M | $4.5M |
| 99 | Housing Relinquished Fund Corporation | Housing & Shelter | $5.4M | $72.4M |
| 100 | Central Valley Medical Services Corporation | Human Services | $5.3M | $6.5M |