| 1 | Tucson Medical Center | Health Care | $960.7M | $714.1M |
| 2 | Association of Universities for | Science & Technology | $482.1M | $125.9M |
| 3 | University of Arizona Foundation | Education | $462.6M | $1.8B |
| 4 | Vantage West Credit Union | Unclassified | $442.2M | $3.1B |
| 5 | El Rio Santa Cruz Neighborhood Health Center INC | Health Care | $325.6M | $197.1M |
| 6 | Epidaurus | Mental Health & Crisis Intervention | $149.1M | $66.7M |
| 7 | Wyant Private Foundation Tr Dtd 032522 | Philanthropy, Voluntarism & Grantmaking | $117.5M | $68.0M |
| 8 | Portable Practical Educational Preparation INC | Human Services | $95.2M | $38.6M |
| 9 | Community Food Bank INC | Food, Agriculture & Nutrition | $93.8M | $57.8M |
| 10 | Community Finance Corporation | Philanthropy, Voluntarism & Grantmaking | $88.0M | $966.9M |
| 11 | Goodwill Industries of Southern Arizona INC | Unclassified | $87.3M | $61.4M |
| 12 | Tmc Medical Network | Health Care | $67.3M | $27.5M |
| 13 | Center for Biological Diversity INC | Animal-Related | $65.4M | $59.2M |
| 14 | Stanley M Reinhaus Family Foundation | Unclassified | $58.1M | $62.4M |
| 15 | Leman Academy of Excellence INC | Education | $54.2M | $141.1M |
| 16 | Commission on Accreditation of Rehabilitation Facilities | Health Care | $51.4M | $127.5M |
| 17 | Jewish Community Foundation of Southern Arizona | Philanthropy, Voluntarism & Grantmaking | $48.9M | $170.8M |
| 18 | Frederick Gardner Cottrell Foundation | Philanthropy, Voluntarism & Grantmaking | $48.7M | $70.0M |
| 19 | United Cerebral Palsy of Southern Arizona INC | Human Services | $48.5M | $31.0M |
| 20 | Child Parent Centers INC | Education | $46.9M | $19.1M |
| 21 | Easterseals Blake Foundation | Human Services | $46.4M | $19.1M |
| 22 | Catholic Community Services of Southern Arizona INC | Unclassified | $44.1M | $30.3M |
| 23 | Lafrontera Center INC | Human Services | $43.8M | $41.2M |
| 24 | Critical Path Institute | Medical Research | $42.6M | $31.3M |
| 25 | Research Corporation | Unclassified | $40.4M | $241.5M |
| 26 | Codac Health Recovery and Wellness | Unclassified | $39.4M | $41.3M |
| 27 | Community Foundation for Southern Arizona | Philanthropy, Voluntarism & Grantmaking | $38.2M | $200.0M |
| 28 | Tmcone | Health Care | $36.1M | $1.4M |
| 29 | Cope Community Services INC | Mental Health & Crisis Intervention | $35.8M | $56.3M |
| 30 | Tmc Health Foundation | Health Care | $35.0M | $58.3M |
| 31 | Tmc Holdings INC | Community Improvement & Capacity Building | $34.1M | $100.4M |
| 32 | Health Care Trust of Sundt Corp. | Unclassified | $33.9M | $9.4M |
| 33 | Beacon Group INC | Human Services | $33.7M | $25.3M |
| 34 | Safari Club International | Animal-Related | $32.9M | $29.6M |
| 35 | Intermountain Centers for Human Development INC | Human Services | $32.3M | $12.1M |
| 36 | Campus Research Corporation | Education | $31.3M | $46.7M |
| 37 | Arizona Community Development Corporation | Education | $30.4M | $27.7M |
| 38 | Habitat for Humanity Tucson INC | Housing & Shelter | $27.5M | $46.6M |
| 39 | Florence Immigrant and Refugee Rights Project INC | Crime & Legal-Related | $26.5M | $35.0M |
| 40 | Arizona Sonora Desert Museum | Arts, Culture & Humanities | $25.9M | $66.1M |
| 41 | Institute for Better Education | Education | $25.5M | $50.8M |
| 42 | Child & Family Resources INC | Human Services | $24.9M | $14.3M |
| 43 | American Board of Radiology Incorporated | Unclassified | $22.9M | $51.9M |
| 44 | Liberty Tradition Charter School | Education | $22.6M | $23.2M |
| 45 | Pusch Ridge Christian Academy INC | Education | $22.2M | $35.6M |
| 46 | Tmc Healthcare | Health Care | $22.1M | $50.6M |
| 47 | Intentional Life Media | Religion-Related | $22.0M | $28.9M |
| 48 | Arizona Aerospace Foundation INC | Arts, Culture & Humanities | $21.9M | $33.0M |
| 49 | United Way of Tucson and Southern Arizona INC | Philanthropy, Voluntarism & Grantmaking | $21.6M | $22.7M |
| 50 | Casa de Los Ninos | Youth Development | $20.3M | $18.5M |
| 51 | Desert Christian Schools INC | Unclassified | $19.6M | $42.2M |
| 52 | Awh Foundation | Unclassified | $19.0M | $2.3M |
| 53 | Southern Arizona Aids Foundation | Diseases, Disorders & Medical Disciplines | $18.8M | $10.0M |
| 54 | Connie Hillman Family Foundation | Philanthropy, Voluntarism & Grantmaking | $18.3M | $12.9M |
| 55 | Metropolitan Tucson Convention and Visitors Bureau | Unclassified | $18.2M | $28.1M |
| 56 | Planetary Science Institute | Unclassified | $17.9M | $5.7M |
| 57 | Youth on Their Own | Human Services | $17.8M | $23.8M |
| 58 | J P Industries INC | Human Services | $15.5M | $23.4M |
| 59 | Kautz Family Foundation | Unclassified | $15.4M | $43.2M |
| 60 | The Primavera Foundation INC | Housing & Shelter | $15.3M | $21.4M |
| 61 | Tucson Jewish Community Center INC | Human Services | $15.3M | $19.2M |
| 62 | Large Binocular Telescope Corporation | Science & Technology | $15.2M | $94.6M |
| 63 | Handmaker Jewish Services for the Aging | Health Care | $15.1M | $3.8M |
| 64 | Childrens Clinics for Rehabilitative Services | Health Care | $14.9M | $11.9M |
| 65 | Tucson Residence Foundation INC | Unclassified | $14.4M | $10.3M |
| 66 | Humane Society of Southern Arizona | Animal-Related | $13.8M | $29.8M |
| 67 | Tucson Symphony Society | Arts, Culture & Humanities | $13.5M | $21.4M |
| 68 | Reid Park Zoological Society | Animal-Related | $13.5M | $19.1M |
| 69 | Pima Association of Governments | Unclassified | $13.4M | $11.1M |
| 70 | Arizonas Catholic Tuition Support Organization | Unclassified | $13.2M | $20.7M |
| 71 | Arizona Baptist Childrens Services | Human Services | $12.8M | $6.9M |
| 72 | Armstrong McDonald Foundation | Unclassified | $12.8M | $22.5M |
| 73 | Pima Community College Foundation INC | Unclassified | $12.5M | $15.9M |
| 74 | Harris Family Foundation | Education | $12.4M | $5.8M |
| 75 | Old Pueblo Community Services | Philanthropy, Voluntarism & Grantmaking | $12.1M | $10.8M |
| 76 | Tucson Country Club | Unclassified | $11.7M | $12.4M |
| 77 | Interfaith Community Services | Unclassified | $11.4M | $11.4M |
| 78 | Tucson Botanical Gardens | Environment | $11.4M | $12.2M |
| 79 | Tucson Center for Women and Children | Human Services | $11.2M | $13.2M |
| 80 | The Gregory School | Unclassified | $11.0M | $9.3M |
| 81 | Soar Consortium INC | Science & Technology | $10.8M | $22.0M |
| 82 | Ruth Tankersley Charitable Tr | Unclassified | $10.5M | $30.1M |
| 83 | Victor W Kramer Charitable Tr | Philanthropy, Voluntarism & Grantmaking | $10.1M | $12.1M |
| 84 | The Womens Foundation for the State of Arizona | Community Improvement & Capacity Building | $9.8M | $9.6M |
| 85 | YMCA of Southern Arizona | Human Services | $9.8M | $17.0M |
| 86 | Jewish Family and Childrens Service of Southern Arizona INC | Human Services | $9.7M | $4.6M |
| 87 | Law College Association of the University of Arizona | Education | $9.7M | $18.8M |
| 88 | Intermountain Health Center INC | Health Care | $9.6M | $5.7M |
| 89 | Rialto Theatre Foundation | Arts, Culture & Humanities | $9.4M | $6.9M |
| 90 | Lapan Sunshine Foundation INC | Unclassified | $9.4M | $30.9M |
| 91 | Gap Community Services | Human Services | $9.1M | $383K |
| 92 | Arizona Capital Source | Unclassified | $8.9M | $23.4M |
| 93 | Arizona Theatre Company | Arts, Culture & Humanities | $8.6M | $3.6M |
| 94 | Southwestern Fair Commission INC | Recreation & Sports | $8.5M | $12.6M |
| 95 | Girl Scouts of Southern Arizona | Youth Development | $8.4M | $2.8M |
| 96 | Boys & Girls Club of Tucson | Youth Development | $8.3M | $16.3M |
| 97 | Helping Ourselves Pursue Enrichment INC | Unclassified | $8.3M | $8.6M |
| 98 | Tucson Youth Development INC | Unclassified | $8.0M | $8.3M |
| 99 | Robert B McMillen Foundation | Philanthropy, Voluntarism & Grantmaking | $7.9M | $6.8M |
| 100 | American Federation of Government Employees | Employment | $7.9M | $9.4M |