| 1 | University of No Ala Foundation | Education | $11.2M | $81.6M |
| 2 | Scope 310 Authority | Employment | $6.8M | $3.2M |
| 3 | El Reposo Nursing Facility | Unclassified | $5.9M | $3.8M |
| 4 | Heritage Christian University | Education | $5.7M | $30.2M |
| 5 | Community Action Agency of Northwest Alabama INC | Unclassified | $4.8M | $600K |
| 6 | The Charlie & Moll Anderson Foundation | Philanthropy, Voluntarism & Grantmaking | $4.6M | $15.9M |
| 7 | 1830 Foundation | Education | $3.0M | $3.3M |
| 8 | Young Mens Christian Association of the Shoals INC | Human Services | $2.7M | $9.3M |
| 9 | Safeplace INC | Unclassified | $2.6M | $3.5M |
| 10 | Joel R Anderson Family Foundation | Philanthropy, Voluntarism & Grantmaking | $2.5M | $3.4M |
| 11 | Riverhill School | Education | $2.2M | $709K |
| 12 | Project Threadways | Education | $2.0M | $800K |
| 13 | Moms INC | Mental Health & Crisis Intervention | $1.6M | $1.5M |
| 14 | Lauderdale County Teachers Credit Union | Unclassified | $1.5M | $35.7M |
| 15 | Shoals Presbyterian Apartments INC | Housing & Shelter | $1.3M | $2.3M |
| 16 | Terry and Susan Anderson Family Foundation | Philanthropy, Voluntarism & Grantmaking | $1.3M | $1.9M |
| 17 | The Chase and Ashley Anderson Family Foundation | Philanthropy, Voluntarism & Grantmaking | $1.2M | $4.8M |
| 18 | United Way of the Northwest Alabama INC | Philanthropy, Voluntarism & Grantmaking | $1.2M | $2.1M |
| 19 | Outdoor Adventures Club | Religion-Related | $1.1M | $818K |
| 20 | Shoals Dream Center INC | Community Improvement & Capacity Building | $955K | $278K |
| 21 | North Alabama Christian Childrens Home | Unclassified | $934K | $2.4M |
| 22 | Shoals Entrepreneurial Center INC | Unclassified | $825K | $1.7M |
| 23 | Shoals Chamber of Commerce INC Fka Chamber of Commerce of Shoals | Unclassified | $733K | $1.5M |
| 24 | Cramer Childerns Center INC | Civil Rights, Social Action & Advocacy | $693K | $392K |
| 25 | Big Brothers Big Sisters of the Shoals INC | Unclassified | $554K | $582K |
| 26 | Riverbend Foundation INC | Philanthropy, Voluntarism & Grantmaking | $539K | $4.3M |
| 27 | Living Proof Ministry | Religion-Related | $530K | $1.2M |
| 28 | Beta Beta Beta Biological Society | Science & Technology | $521K | $1.1M |
| 29 | Attention Homes of Northwest Alabama INC | Human Services | $513K | $665K |
| 30 | Nazareth Educational Ministries Association INC | Religion-Related | $465K | $236K |
| 31 | Caringplace of the Shoals INC | Human Services | $437K | $509K |
| 32 | Anderson Foundation | Unclassified | $406K | $2.6M |
| 33 | Tri-state Inspirational Broadcasting Corporation | Unclassified | $396K | $274K |
| 34 | One Place of the Shoals INC | Human Services | $382K | $878K |
| 35 | Project Say Something | Civil Rights, Social Action & Advocacy | $381K | $134K |
| 36 | Gresham Hills INC | Housing & Shelter | $377K | $1.0M |
| 37 | Florence-lauderdale Industrial Expansion Committee INC | Unclassified | $375K | $5.9M |
| 38 | Community Theater INC | Arts, Culture & Humanities | $375K | $764K |
| 39 | Eyes Wide Open Ministries INC | Religion-Related | $370K | $229K |
| 40 | Mission Sending Service | International, Foreign Affairs & National Security | $366K | $62K |
| 41 | Shoals Scholar Dollars Foundation INC | Education | $357K | $445K |
| 42 | Shoals Sav-a-life INC | Religion-Related | $350K | $915K |
| 43 | Shoals Symphony Orchestra | Unclassified | $346K | $113K |
| 44 | Christian Services Foundation | Unclassified | $342K | $1.5M |
| 45 | Muscle Shoals Area Board of Realtors INC | Unclassified | $333K | $1.1M |
| 46 | Liberte Ministries | Religion-Related | $320K | $121K |
| 47 | Edith Martin Ruggles and Donald F Ruggles Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $293K | $1.2M |
| 48 | Kingdom Connections International INC | Religion-Related | $287K | $390K |
| 49 | Home Builders Association of the Muscle Shoals Area | Unclassified | $278K | $551K |
| 50 | University of North Alabama Sportsmans Club | Education | $277K | $217K |
| 51 | Alpha Gamma Delta Fraternity | Unclassified | $270K | $305K |
| 52 | St. Vincent de Paul Thrift Store INC | Unclassified | $253K | $336K |
| 53 | Deiberts Rolling Acres Farm Foundation | Unclassified | $237K | $1.4M |
| 54 | Hasra INC | Animal-Related | $234K | $157K |
| 55 | Benevolent & Protective Order of Elks of the USA | Mutual & Membership Benefit | $233K | $130K |
| 56 | Florence All Stars | Recreation & Sports | $226K | $55K |
| 57 | United Brotherhood of Carpenters & Joiners of America | Unclassified | $219K | $212K |
| 58 | Christian Student Fellowship 547 Oakview Cir | Religion-Related | $195K | $241K |
| 59 | Common Ground Shoals INC | Religion-Related | $195K | $96K |
| 60 | Building Believers in Christ | International, Foreign Affairs & National Security | $193K | $228K |
| 61 | Kennedy-douglass Center for the Arts Volunteers INC | Unclassified | $193K | $226K |
| 62 | Childrens Museum of the Shoals INC | Arts, Culture & Humanities | $190K | $528K |
| 63 | Independent Living Associates of the Muscle Shoals Area INC | Unclassified | $188K | $329K |
| 64 | Shoals Soccer Club Incorporated | Recreation & Sports | $174K | $59K |
| 65 | Bear Creek Collaborative | Recreation & Sports | $168K | $180K |
| 66 | Lauderdale County Sheriffs Posse INC | Public Safety, Disaster Preparedness & Relief | $160K | $42K |
| 67 | Shylee Smiles | Arts, Culture & Humanities | $154K | $25K |
| 68 | The Central Area Volunteer Fire Department INC | Unclassified | $150K | $218K |
| 69 | Downtown Florence Alliance | Community Improvement & Capacity Building | $136K | $147K |
| 70 | Shoals Community Clinic | Health Care | $134K | $167K |
| 71 | Chloesfundlimited | Animal-Related | $133K | $22K |
| 72 | Florence City Schools Education Foundation | Philanthropy, Voluntarism & Grantmaking | $131K | $229K |
| 73 | Society of St. Vincent Depaul St. Joseph Conference INC | Unclassified | $125K | $24K |
| 74 | Bibles for Russia INC | Unclassified | $123K | $83K |
| 75 | Dyslexia Center of the Shoals | Diseases, Disorders & Medical Disciplines | $117K | $13K |
| 76 | Rotary International | Unclassified | $114K | $57K |
| 77 | Shoals Area Chamber Foundation INC | Community Improvement & Capacity Building | $102K | $201K |
| 78 | Eden Calhoun Charitable Fund INC | Housing & Shelter | $99K | $115K |
| 79 | The Cooperative Community Ministries INC | Unclassified | $98K | $251K |
| 80 | Florence Lodge No 2034 Loyal Order of Moose | Unclassified | $91K | $215K |
| 81 | Sacred Healing Circle | Diseases, Disorders & Medical Disciplines | $90K | $250 |
| 82 | Pets Are Worth Saving INC | Animal-Related | $89K | $71K |
| 83 | Tnt Fireworks Associate Assistance Fund | Public Safety, Disaster Preparedness & Relief | $89K | $596K |
| 84 | Zip City Volunteer Fire Department | Public Safety, Disaster Preparedness & Relief | $87K | $188K |
| 85 | Greenhill Volunteer Fire Dept | Public Safety, Disaster Preparedness & Relief | $82K | $197K |
| 86 | Holos Hope Nfp | Mental Health & Crisis Intervention | $81K | $23K |
| 87 | Selah Ministries INC | Religion-Related | $81K | $73K |
| 88 | Northwest Alabama Spay and Neuter Assistance | Animal-Related | $80K | $31K |
| 89 | Burns Junior Golf Foundation | Recreation & Sports | $76K | $13K |
| 90 | Florence Parks and Recreation Foundation | Recreation & Sports | $73K | $70K |
| 91 | Branch 892 of the National Association of Letter Carriers of | Unclassified | $71K | $43K |
| 92 | American Legion | Unclassified | $65K | $627K |
| 93 | Florence Library Foundation INC | Education | $61K | $2.8M |
| 94 | Baker Family Foundation | Philanthropy, Voluntarism & Grantmaking | $60K | $55K |
| 95 | Beth B Anderson Family Foundation | Philanthropy, Voluntarism & Grantmaking | $57K | $533K |
| 96 | Homeless Care Council of Northwest Alabama INC | Unclassified | $56K | $12K |
| 97 | A Gateway to Opportunity Foundation | Philanthropy, Voluntarism & Grantmaking | $55K | $328K |
| 98 | Ellen Mitchell Redd Foundation | Unclassified | $53K | $279K |
| 99 | Singing River Disc Golf | Recreation & Sports | $51K | $6K |
| 100 | Friends of the Florence Lauderdale Public Library | Unclassified | $50K | $90K |