| 1 | University of Delaware Newark | $3.0B | $0 | $4.6B |
| 2 | Delaware Electric Cooperative INC Greenwood | $254.9M | $254.8M | $452.2M |
| 3 | The Champlin Foundation Wilmington | $232.7M | $0 | $456.6M |
| 4 | Moccasin Lake Foundation Wilmington | $76.6M | $0 | $107.0M |
| 5 | Raskob Foundation for Catholic Activities Incorporated Wilmington | $74.8M | $0 | $208.0M |
| 6 | Welfare Foundation INC Wilmington | $65.5M | $0 | $106.7M |
| 7 | J B L Scholarship Trust Wilmington | $60.9M | $0 | $10.4M |
| 8 | Louis and Anne Abrons Foundation INC Wilmington | $49.4M | $0 | $125.9M |
| 9 | Crystal Trust Ua Dtd 12-25-47 Irenee Dupont Jr Ttee Montchanin | $37.8M | $0 | $241.7M |
| 10 | Herbert and Nell Singer Foundation INC Wilmington | $37.5M | $0 | $60.9M |
| 11 | Life at St. Francis Healthcare INC Wilmington | $37.2M | $37.2M | $33.9M |
| 12 | Boys and Girls Club of Delaware INC Wilmington | $35.2M | $32.1M | $57.2M |
| 13 | Westside Family Healthcare INC Wilmington | $34.3M | $34.3M | $26.2M |
| 14 | Charles R Wood Foundation Wilmington | $34.0M | $0 | $45.7M |
| 15 | Aec Trust Wilmington | $31.9M | $0 | $36.8M |
| 16 | The Singer Family Charitable Foundation Wilmington | $29.6M | $0 | $14.9M |
| 17 | Bess Spiva Timmons Foundation INC Wilmington | $27.4M | $0 | $2.2M |
| 18 | J M McDonald Foundation INC Wilmington | $26.3M | $0 | $29.8M |
| 19 | Dunn Foundation Wilmington | $26.3M | $0 | $92.6M |
| 20 | Laurie Kayden Foundation Wilmington | $26.0M | $0 | $66.0M |
| 21 | Riedman Foundation Wilmington | $25.2M | $0 | $42.6M |
| 22 | Mt Cuba Center INC Hockessin | $20.6M | $0 | $426.1M |
| 23 | Wilmington Country Club Wilmington | $20.6M | $20.6M | $36.4M |
| 24 | Jewish Federation of Delaware INC Wilmington | $20.3M | $7.6M | $46.1M |
| 25 | Ministry of Caring INC Wilmington | $19.0M | $10.5M | $55.2M |
| 26 | Rehoboth Beach Country Club INC Rehoboth Bch | $17.5M | $11.3M | $25.4M |
| 27 | Slemp Foundation Wilmington | $17.0M | $0 | $28.8M |
| 28 | Wendy P McCaw Foundation Wilmington | $16.9M | $0 | $30.7M |
| 29 | Ortega Charitable Foundation Wilmington | $16.6M | $0 | $38.8M |
| 30 | Windhover Foundation INC Wilmington | $16.1M | $0 | $64.2M |
| 31 | Mars Wrigley Foundation Wilmington | $14.2M | $0 | $40.6M |
| 32 | Enoch Foundation Charitable Tr 100892 Wilmington | $14.1M | $0 | $26.8M |
| 33 | Lightner Sams Foundation INC Wilmington | $14.1M | $0 | $11.3M |
| 34 | Independence School INC Newark | $13.8M | $12.8M | $29.1M |
| 35 | Nancy Woodson Spire Foundation INC Greenville | $13.7M | $0 | $28.4M |
| 36 | James S and Gail P Riepe Charitable Foundation Wilmington | $13.2M | $0 | $47.2M |
| 37 | Delaware Life and Health Insurance Guaranty Assn. Newark | $13.2M | $13.2M | $5.5M |
| 38 | Wilson & Johnson Private Foundation Wilmington | $12.6M | $0 | $17.3M |
| 39 | Ellice and Rosa McDonald Foundation INC Wilmington | $12.5M | $0 | $25.7M |
| 40 | Wasily Family Foundation Wilmington | $12.5M | $0 | $43.9M |
| 41 | Six String Giving Foundation Wilmington | $11.9M | $0 | $20.2M |
| 42 | Kings Creek Country Club INC Rehoboth | $11.8M | $8.0M | $20.6M |
| 43 | Lennox Foundation Wilmington | $11.7M | $0 | $42.9M |
| 44 | Wiggins Foundation INC Wilmington | $11.7M | $0 | $20.5M |
| 45 | Jerome S and Grace H Murray Foundation Wilmington | $11.5M | $0 | $17.2M |
| 46 | Laffey-mchugh Foundation Wilmington | $11.0M | $0 | $66.1M |
| 47 | Collin and Joanna Roche Family Foundation Wilmington | $10.6M | $0 | $10.3M |
| 48 | Good Samaritan INC Wilmington | $10.6M | $0 | $13.3M |
| 49 | Winslow Foundation Wilmington | $10.5M | $0 | $30.4M |
| 50 | Jonathan and Meredith Meeks Foundation Wilmington | $9.9M | $0 | $14.5M |