| 1 | American Society for Testing and Materials Conshohocken | $272.0M | $134.7M | $506.1M |
| 2 | National Center for Defense Manufacturing and Machining Johnstown | $112.2M | $112.2M | $29.2M |
| 3 | Concurrent Technologies Corporation Johnstown | $104.4M | $101.3M | $83.6M |
| 4 | Sae International Warrendale | $103.3M | $95.1M | $110.7M |
| 5 | University City Science Center Philadelphia | $49.1M | $20.8M | $136.2M |
| 6 | Advanced Robotics for Manufacturing Institute Pittsburgh | $41.6M | $41.6M | $8.9M |
| 7 | Academy of Natural Sciences of Philadelphia Philadelphia | $27.2M | $22.4M | $107.1M |
| 8 | Future of Life Institute Narberth | $21.3M | $21.3M | $6.3M |
| 9 | Jcpds International Centre for Diffraction Data Newtown Sq | $20.1M | $12.0M | $35.7M |
| 10 | Society for Industrial and Applied Mathematics Philadelphia | $18.2M | $17.7M | $61.1M |
| 11 | Stroud Water Research Center INC Avondale | $14.5M | $11.9M | $59.1M |
| 12 | National Cyber Forensics and Training Alliance Pittsburgh | $10.6M | $10.5M | $21.9M |
| 13 | Science History Institute Philadelphia | $10.4M | $9.3M | $39.7M |
| 14 | Iup Research Institute Indiana | $10.2M | $9.7M | $8.6M |
| 15 | Catalyst Connection Pittsburgh | $9.6M | $9.6M | $7.6M |
| 16 | Minerals Metals & Materials Society INC Pittsburgh | $9.5M | $8.7M | $12.5M |
| 17 | Wadhwani Institute for Artificial Intelligence Foundation Bridgeville | $8.3M | $0 | $7.5M |
| 18 | Iop Publishing Incorporated Philadelphia | $5.3M | $5.3M | $1.7M |
| 19 | Pittsburgh Conference on Analytic Chemistry & Applied Spectroscopy Monroeville | $5.0M | $5.0M | $11.1M |
| 20 | Advanced Manufacturing International Johnstown | $2.9M | $2.9M | $1.1M |
| 21 | Lifex Greenhouse INC Pittsburgh | $2.7M | $2.7M | $5.5M |
| 22 | Combustion Institute Pittsburgh | $2.2M | $0 | $8.9M |
| 23 | Pennsylvania Center for Poultry and Livestock Excellence Harrisburg | $1.0M | $1.0M | $1.1M |
| 24 | American Entomological Society Philadelphia | $995K | $0 | $4.9M |
| 25 | Vytal Plant Science Research Harrisburg | $914K | $914K | $247K |
| 26 | Open Library Foundation Philadelphia | $844K | $844K | $744K |
| 27 | E Dauch Tr Fbo Cu Ld Geo Observ Pittsburgh | $816K | $0 | $1.4M |
| 28 | Bighorn Basin Paleontological Institute Willow Grove | $642K | $636K | $832K |
| 29 | International Conference on Environmental Systems INC Emmaus | $636K | $636K | $386K |
| 30 | Ben Franklin Technology Partners Corporation Bethlehem | $475K | $475K | $234K |
| 31 | Tecbridge Scranton | $435K | $435K | $136K |
| 32 | Catherine Gives Jenkintown | $311K | $0 | $280K |
| 33 | Partnership to Advance Responsible Technology Pittsburgh | $298K | $298K | $318K |
| 34 | American Chemical Society University Park | $284K | $284K | $3.0M |
| 35 | Electronic Materials Conference Kennett Sq | $237K | $237K | $146K |
| 36 | Sarah Mack Scicomm INC Philadelphia | $227K | $227K | $261K |
| 37 | International Society of Lyophilization-freeze Drying INC Glenmoore | $219K | $219K | $244K |
| 38 | International Society for Anthrozoology INC Lancaster | $213K | $213K | $199K |
| 39 | Eastern Pa and Delaware Chapter Ofamerican Concrete Institute Havertown | $180K | $180K | $184K |
| 40 | American Chemical Society Holland | $179K | $179K | $874K |
| 41 | Pennsylvania First Robotics Landenberg | $174K | $174K | $94K |
| 42 | North American Society for Bat Research Lewisburg | $172K | $172K | $168K |
| 43 | World Tumor Registry INC Pittsburgh | $170K | $170K | $84K |
| 44 | Punxsutawney Weather Center INC Punxsutawney | $169K | $159K | $540K |
| 45 | Dhody Research Institute Oreland | $159K | $159K | $25K |
| 46 | Three Rivers Information Security Institute Penn Hills | $141K | $141K | $11K |
| 47 | Lepidopterists Society Bolivar | $127K | $127K | $753K |
| 48 | Northstar of Gis Philadelphia | $125K | $125K | $135K |
| 49 | Delaware Valley Association of Structural Engineers Warminster | $114K | $114K | $80K |
| 50 | Teknowledge Worldwide Corp. Warminster | $92K | $92K | $59K |