| 1 | Cold Spring Harbor Laboratory Cold Spg Hbr | $482.3M | $232.7M | $1.4B |
| 2 | American Society of Mechanical Engineers New York | $154.8M | $136.7M | $226.6M |
| 3 | Association for Computing Machinery INC New York | $124.5M | $88.3M | $264.8M |
| 4 | Cubrc INC Buffalo | $57.0M | $57.0M | $49.8M |
| 5 | Boyce Thompson Institute for Plant Research INC Ithaca | $47.7M | $15.5M | $85.5M |
| 6 | Ny Creates Albany | $43.1M | $43.1M | $49.1M |
| 7 | Robertson Research Fund INC Cold Spg Hbr | $33.6M | $10.1M | $141.4M |
| 8 | Griffiss Institute INC Rome | $27.9M | $27.9M | $7.0M |
| 9 | Project Liberty Institute New York | $26.6M | $26.6M | $7.5M |
| 10 | Scratch Foundation New York | $20.0M | $20.0M | $13.7M |
| 11 | New York Structural Biology Center INC New York | $20.0M | $20.0M | $133.9M |
| 12 | Acoustical Society of America Melville | $14.2M | $7.4M | $27.5M |
| 13 | Sustainable Manufacturing Innovation Alliance Corp. W Henrietta | $13.8M | $13.8M | $8.0M |
| 14 | Explorers Club New York | $13.3M | $6.4M | $18.0M |
| 15 | The Asme Foundation INC New York | $9.2M | $6.2M | $37.8M |
| 16 | Powermylearning INC New York | $7.1M | $5.9M | $4.5M |
| 17 | Mirror Biology Dialogues Fund New York | $6.2M | $6.2M | $5.7M |
| 18 | American Vacuum Society Incorporated New York | $6.2M | $6.2M | $18.2M |
| 19 | Openmined Foundation New York | $6.1M | $6.1M | $3.7M |
| 20 | Project Ceti INC New York | $6.0M | $6.0M | $13.8M |
| 21 | New York Sun Works INC New York | $5.9M | $5.9M | $4.6M |
| 22 | Science Friday Initiative INC New York | $5.4M | $4.6M | $8.8M |
| 23 | American Center for Optics Manufacturing INC Fairport | $4.9M | $4.9M | $7.7M |
| 24 | Fragrance Foundation INC New York | $4.9M | $4.8M | $4.7M |
| 25 | Basis Research Institute New York | $4.7M | $4.7M | $4.1M |
| 26 | World Science Foundation New York | $4.5M | $4.5M | $19.3M |
| 27 | Engineering Conferences International INC New York | $3.9M | $3.8M | $2.6M |
| 28 | Science Philanthropy Alliance INC New York City | $3.6M | $3.6M | $3.6M |
| 29 | Software Freedom Conservancy INC Brooklyn | $3.2M | $3.2M | $5.4M |
| 30 | New York City Foundation for Computer Science Education Katonah | $3.1M | $3.1M | $1.2M |
| 31 | Mental Health Empowerment Project INC Albany | $3.0M | $3.0M | $1.5M |
| 32 | Policy Research INC Troy | $2.9M | $2.9M | $1.4M |
| 33 | American Friends of Zichron Nechama INC Brooklyn | $2.9M | $2.9M | $0 |
| 34 | Albany Research Institute INC Albany | $2.7M | $2.7M | $1.5M |
| 35 | Society of Cosmetic Chemists New York | $2.6M | $2.2M | $2.1M |
| 36 | Open Athena Foundation INC New York | $2.5M | $0 | $2.3M |
| 37 | Center for Financial Stability INC New York | $2.4M | $2.4M | $3.0M |
| 38 | National Institute of Innovation and Technology INC Saratoga Spgs | $2.4M | $2.4M | $311K |
| 39 | 4YOUANDME Great Neck | $2.3M | $2.3M | $1.3M |
| 40 | Shevchenko Scientific Society INC New York | $2.3M | $999K | $9.4M |
| 41 | Research Applied Technologyeducation Service Incorporated Potsdam | $2.2M | $2.2M | $1.2M |
| 42 | Western New York Technology Development Center INC Buffalo | $2.1M | $2.1M | $1.1M |
| 43 | Horological Society of New York INC New York | $1.8M | $1.5M | $2.2M |
| 44 | Neptunes Navy INC New York | $1.8M | $1.8M | $76K |
| 45 | Entropy Software Foundation INC Woodbury | $1.4M | $0 | $33K |
| 46 | Guild of Future Architects Foundation New York | $1.2M | $1.2M | $731K |
| 47 | Brain Trauma Foundation INC New York | $1.2M | $1.2M | $938K |
| 48 | Open Transformation Lab INC New York City | $1.1M | $1.1M | $409K |
| 49 | Carbon Removal Institute Brooklyn | $930K | $930K | $268K |
| 50 | Fondation Sante Great Neck | $929K | $0 | $1.4M |