| 1 | Fermi Research Alliance LLC Batavia | $715.5M | $715.5M | $18.9M |
| 2 | Institute of Gas Technology Des Plaines | $142.5M | $124.2M | $157.7M |
| 3 | Iit Research Institute Chicago | $28.7M | $28.7M | $42.2M |
| 4 | American Nuclear Society INC Westmont | $21.3M | $13.8M | $28.1M |
| 5 | Society for Laboratory Automation and Screening Oak Brook | $11.3M | $8.7M | $16.1M |
| 6 | Two Blades Foundation Evanston | $10.0M | $10.0M | $13.3M |
| 7 | Applied Science and Technology Research Organization of Americs Moline | $8.8M | $8.8M | $5.9M |
| 8 | International Society for Heart & Lung Transplants Chicago | $7.1M | $7.1M | $19.2M |
| 9 | American Oil Chemists Society Champaign | $5.0M | $5.0M | $3.7M |
| 10 | Society of Tribologists & Lubrication Engineers Park Ridge | $4.8M | $3.5M | $4.9M |
| 11 | American Ornithological Society Chicago | $4.2M | $2.3M | $34.7M |
| 12 | Sequoia Farm Foundation Decatur | $3.1M | $0 | $107.3M |
| 13 | Science Olympiad Oakbrook Ter | $3.1M | $2.5M | $9.5M |
| 14 | Lumity Chicago | $3.0M | $2.9M | $1.9M |
| 15 | The Hdf Group Champaign | $2.5M | $2.5M | $2.4M |
| 16 | Center for Humans and Nature Nfp Libertyville | $2.3M | $1.6M | $10.5M |
| 17 | International Valuation Standards Committee Chicago | $2.2M | $2.2M | $3.9M |
| 18 | Vibration Institute Naperville | $2.1M | $2.1M | $3.1M |
| 19 | Peggy and Steve Fossett Foundation Chicago | $2.0M | $0 | $21.4M |
| 20 | Open Source Technology Improvement Fund INC Chicago | $1.7M | $1.7M | $62K |
| 21 | Heartland Science and Technology Group Chillicothe | $1.5M | $1.5M | $564K |
| 22 | American Society for Bioethics and Humanities Schaumburg | $1.5M | $1.4M | $892K |
| 23 | National Conference of Standards Laboratories Glen Ellyn | $1.4M | $1.4M | $306K |
| 24 | International Foundation of Microbiology Glen Ellyn | $792K | $655K | $600K |
| 25 | Aps Training Institute INC Aurora | $687K | $287K | $9K |
| 26 | Mrens Nfp La Grange | $552K | $552K | $116K |
| 27 | Rheumatology Research and Educational Fund INC Chicago | $501K | $0 | $781K |
| 28 | Chicago Council on Science Andtechnology Chicago | $449K | $433K | $124K |
| 29 | Angaza Technology Literacy Center Nfp Lincolnshire | $416K | $411K | $417K |
| 30 | The Lawn Institute Foundation Lombard | $358K | $285K | $1.2M |
| 31 | Lauer Foundation for Paleontology Science and Education Nfp Wheaton | $354K | $0 | $6.6M |
| 32 | Innovative Pavement Research Foundation Rosemont | $282K | $277K | $446K |
| 33 | Thotcon Infinity Nfp Chicago | $248K | $248K | $292K |
| 34 | Steel Fabricators of New England Chicago | $190K | $137K | $195K |
| 35 | Society of Cosmetic Chemists Chicago | $173K | $173K | $286K |
| 36 | Ibio Institute Chicago | $168K | $168K | $989K |
| 37 | American Chemical Society Elmhurst | $166K | $166K | $2.6M |
| 38 | Institute for Population Health Sciences Chicago | $137K | $137K | $543K |
| 39 | Non Profit Software Corporation Dekalb | $123K | $123K | $51K |
| 40 | Dataplaneorg Nfp Chicago | $112K | $112K | $113K |
| 41 | Illini Robotics Champaign | $105K | $105K | $58K |
| 42 | African American Family Research Institute Chicago | $101K | $101K | $92K |
| 43 | Metropolitan Conference on Public Transportation Research Chicago | $83K | -$2K | $6K |
| 44 | Iris Foundation Chicago | $79K | $79K | $124 |
| 45 | Asymmetric Biodiversity Studies &observation Group Nfp Mattoon | $75K | $0 | $1.6M |
| 46 | Center for Stable Isotope Research INC Chicago | $73K | $0 | $650K |
| 47 | Martin Motion Neponset | $66K | $65K | $6K |
| 48 | International Epr Society Chicago | $64K | $64K | $133K |
| 49 | Research Council on Structural Connections Chicago | $59K | $0 | $452K |
| 50 | Association of Chinese Scientists & Engineers Schaumburg | $53K | $53K | $25K |