| 1 | Defensewerx INC Niceville | $112.5M | $112.5M | $96.6M |
| 2 | Florida Institute for Human and Machine Cognition Pensacola | $33.2M | $33.2M | $63.8M |
| 3 | International Seakeepers Society INC Coral Gables | $31.4M | $31.2M | $62.4M |
| 4 | Harbor Branch Oceanographic Institution Foundation INC Vero Beach | $23.4M | $10.0M | $129.5M |
| 5 | Center for the Advancement of Science in Space INC Merritt Island | $19.5M | $19.5M | $5.4M |
| 6 | Tall Timbers Research INC Tallahassee | $17.5M | $16.9M | $50.8M |
| 7 | Loggerhead Marinelife Center INC Juno Beach | $11.9M | $9.4M | $30.8M |
| 8 | Biomedical Research & Longevity Society INC Ft Lauderdale | $9.7M | $8.6M | $44.6M |
| 9 | Mote Marine Foundation INC Sarasota | $9.3M | $2.2M | $16.7M |
| 10 | Stephenson Stellar Corporation Ponte Vedra Beach | $8.6M | $8.6M | $3.6M |
| 11 | Marine Resources Development Foundation Key Largo | $6.8M | $6.7M | $27.8M |
| 12 | Marine Science Foundation Stuart | $6.0M | $6.0M | $10.9M |
| 13 | Imec USA Nanoelectronics Design Center Kissimmee | $5.8M | $5.8M | $10.3M |
| 14 | Kuyr Institute High Springs | $4.0M | $4.0M | $4.0M |
| 15 | Florida Oceanographic Society INC Stuart | $3.7M | $3.4M | $11.1M |
| 16 | National Academy of Inventors INC Tampa | $3.7M | $3.7M | $6.6M |
| 17 | Manufacturing Technology Deployment Group Clearwater | $3.3M | $3.3M | $65K |
| 18 | Charles F Chapman School of Seamanship INC Stuart | $2.9M | $2.8M | $5.2M |
| 19 | Ataxia Telangiectasia Childrens Project INC Coconut Creek | $2.8M | $2.5M | $2.8M |
| 20 | Adventureland Institute INC St. Petersburg | $2.4M | $2.4M | $32K |
| 21 | Blue World Research Institute INC Cocoa | $2.4M | $0 | $393K |
| 22 | United Sacrament Mobile Int INC Miami | $1.9M | $1.9M | $4.8M |
| 23 | Inwater Group Research INC Jensen Beach | $1.8M | $1.8M | $523K |
| 24 | Electronic Discovery Institute Ft Lauderdale | $1.6M | $1.6M | $1.9M |
| 25 | The Aldrin Family Foundation INC Melbourne | $1.5M | $1.5M | $490K |
| 26 | Gulf Specimen Marine Laboratories INC Panacea | $1.5M | $1.5M | $2.1M |
| 27 | Innovation Park Tlh INC Tallahassee | $1.5M | $1.5M | $1.5M |
| 28 | Spacetec Partners INC Titusville | $1.4M | $1.4M | $1.2M |
| 29 | Plantrician Project Boynton Beach | $1.4M | $1.4M | $674K |
| 30 | Watson Caring Science Institute Deerfield Bch | $1.1M | $1.1M | $686K |
| 31 | Lemur Conservation Foundation INC Myakka City | $1.1M | $1.1M | $9.9M |
| 32 | Global Underwater Explorers INC High Springs | $945K | $913K | $546K |
| 33 | Environmental Mutagenesis and Genomics Society Emgs Jacksonville | $891K | $339K | $2.2M |
| 34 | Dolphin Biology Research Institute INC Sarasota | $814K | $812K | $902K |
| 35 | Paradox Science Institute Miami | $800K | $0 | $238K |
| 36 | Florida Wildflower Foundation INC Maitland | $725K | $725K | $1.7M |
| 37 | Tampa Bay Technology Forum INC Tampa | $711K | $672K | $1.2M |
| 38 | US Inventor INC Clearwater | $686K | $686K | $9K |
| 39 | Bimini Biological Field Station Foundation INC Hollywood | $671K | $586K | $2.0M |
| 40 | Ocean Rescue Alliance INC Apollo Beach | $664K | $664K | $265K |
| 41 | Dciia Retirement Research Center Jupiter | $659K | $659K | $28K |
| 42 | Florida Fruit & Vegetable Research & Education Foundation INC Maitland | $552K | $486K | $1.4M |
| 43 | Saving the Blue INC Davie | $523K | $523K | $304K |
| 44 | Association of Engineering Geologists Belleair Blf | $512K | $512K | $1.1M |
| 45 | The Citizen Scientists League INC Sarasota | $508K | $508K | $192K |
| 46 | Cato Neonatal Innovations INC Delray Beach | $481K | $481K | $370K |
| 47 | Vagus Nerve Society Vns INC Atlantic Beach | $458K | $458K | $230K |
| 48 | Latin American and Caribbean Con Sortium of Engineering Inst INC Boca Raton | $454K | $454K | $330K |
| 49 | Healthspan Action Coalition INC Wellington | $405K | $405K | $30K |
| 50 | Bhaktivedanta Institute for Higher Studies INC Gainesville | $402K | $402K | $35K |