| 1 | Alliance for Sustainable Energy LLC Lakewood | $1.0B | $1.0B | $232.2M |
| 2 | University Corporation for Atmospheric Research Boulder | $400.2M | $311.0M | $356.7M |
| 3 | Clay Mathematics Institute INC Denver | $58.3M | $0 | $49.3M |
| 4 | Geological Society of America INC Boulder | $32.0M | $12.8M | $53.8M |
| 5 | Keystone Symposia on Molecular and Cellular Biology Silverthorne | $25.0M | $12.1M | $21.6M |
| 6 | Society for Mining Metallurgy and Exploration INC Englewood | $23.7M | $18.6M | $41.3M |
| 7 | Geological Society of America Foundation Boulder | $17.7M | $4.8M | $36.7M |
| 8 | Engineering Ministries International USA Colorado Spgs | $14.8M | $14.7M | $19.2M |
| 9 | Space Science Institute Boulder | $8.9M | $8.9M | $2.3M |
| 10 | University License Equity Holdings INC Aurora | $8.7M | $8.6M | $20.0M |
| 11 | Rocky Mountain Biological Laboratory at Gothic Crested Butte | $5.8M | $5.1M | $16.5M |
| 12 | Population Biology Foundation Grand Junction | $5.1M | $0 | $3.0M |
| 13 | Build Change Denver | $4.6M | $4.6M | $4.4M |
| 14 | The Freebsd Foundation Boulder | $4.3M | $1.7M | $4.1M |
| 15 | Society of Asian Scientists and Engineers Denver | $3.7M | $3.7M | $2.1M |
| 16 | Aspen Center for Physics Aspen | $3.4M | $3.4M | $8.5M |
| 17 | American Chemical Society Loveland | $2.5M | $1.5M | $8.2M |
| 18 | Jerry Romano Foundation INC Denver | $2.0M | $0 | $2.0M |
| 19 | Orient Land Trust Moffat | $1.7M | $1.7M | $4.7M |
| 20 | Partnership for Clean Competition Research Collaborative Colorado Spgs | $1.6M | $1.6M | $2.3M |
| 21 | Higher Orbits Foundation Aurora | $1.2M | $1.2M | $796K |
| 22 | Upper Colorado Environmental Plant Center Meeker | $1.1M | $1.1M | $1.7M |
| 23 | Rocky Mountain Institute International Boulder | $1.0M | $1.0M | $0 |
| 24 | North American Arabidopsis Steering Committee Fort Collins | $635K | $635K | $282K |
| 25 | Tinkermill Longmont | $634K | $574K | $1.6M |
| 26 | Data-driven Economic Strategies INC Monument | $575K | $575K | $261K |
| 27 | Space for Humanity Boulder | $557K | $557K | $963K |
| 28 | Two Frontiers Project INC Fort Collins | $538K | $538K | $286K |
| 29 | Idea Wild Fort Collins | $530K | $530K | $573K |
| 30 | Fins Attached Marine Research and Conservation Colorado Spgs | $496K | $496K | $395K |
| 31 | Targeted Meteorological Systems INC Boulder | $484K | $484K | $933K |
| 32 | Rmi Lab Properties INC Fort Collins | $445K | $445K | $5.5M |
| 33 | Paleocultural Research Group Longmont | $319K | $319K | $66K |
| 34 | White Dwarf Research Corporation Golden | $305K | $305K | $449K |
| 35 | Mars Society INC Lakewood | $284K | $284K | $495K |
| 36 | Bible Archeology Search and Exploration Foundation Colorado Spgs | $264K | $264K | $186K |
| 37 | Comms Vnext Lafayette | $235K | $235K | $185K |
| 38 | Rocky Mountain Association of Geologists Denver | $233K | $184K | $1.9M |
| 39 | International Association Offorensic Toxicologists Colorado Spgs | $208K | $208K | $347K |
| 40 | Rocky Mountain Conference Onanalytical Chemistry INC Denver | $200K | $200K | $212K |
| 41 | Thrive-wise Boulder | $131K | $131K | $140K |
| 42 | Mines Applied Technology Transfer INC Golden | $117K | $117K | $16K |
| 43 | Csa Colorado INC Arvada | $107K | $0 | $68K |
| 44 | The Colorado Section of the American Chemical Society Golden | $98K | $98K | $366K |
| 45 | Active Archive Alliance Westminster | $88K | $88K | $66K |
| 46 | Institute of Transportation Engineers - Nevada Section Morrison | $87K | $0 | $75K |
| 47 | Mountain District of the Institute of Transportation Engineers Morrison | $86K | $86K | $33K |
| 48 | Darksky Colorado Paonia | $79K | $79K | $10K |
| 49 | Tree-ring Society Loveland | $77K | $77K | $63K |
| 50 | Northern Research Technical Assistance Center Littleton | $76K | $76K | $552 |