| 1 | The Blackbaud Giving Fund Daniel Island | $561.4M | $561.4M | $52.7M |
| 2 | Apella Health Management INC Spartanburg | $473.8M | $473.8M | $78.4M |
| 3 | Joy Unspeakable Foundation Charleston | $176.3M | $0 | $463.9M |
| 4 | Coastal Community Foundation of South Carolina INC N Charleston | $103.4M | $46.3M | $435.6M |
| 5 | Hollingsworth Funds INC Greenville | $80.7M | $18.6M | $406.7M |
| 6 | Darla Moore and Richard Rainwater Foundation Lake City | $78.0M | $0 | $658.1M |
| 7 | Community Foundation of Greenville INC Greenville | $71.8M | $37.6M | $118.8M |
| 8 | Bluecross Blueshield of South Carolina Foundation Columbia | $70.9M | $0 | $357.9M |
| 9 | We Are Sharing Hope Sc Charleston | $49.4M | $49.3M | $58.1M |
| 10 | Spartanburg County Foundation Spartanburg | $48.6M | $48.6M | $247.9M |
| 11 | Central Carolina Community Foundation Columbia | $39.9M | $39.8M | $229.7M |
| 12 | Drs Bruce & Lee Foundation Florence | $32.5M | $0 | $255.4M |
| 13 | Darnall W Boyd Foundation INC Columbia | $26.2M | $0 | $148.7M |
| 14 | Iversen Family Foundation Six Mile | $22.2M | $0 | $24.5M |
| 15 | Moore Farms Botanical Garden Foundation Lake City | $21.1M | $0 | $27.5M |
| 16 | Lb Foundation Greenville | $19.8M | $0 | $67.1M |
| 17 | Heritage Classic Foundation Hilton Head | $19.0M | $19.0M | $16.8M |
| 18 | Community Foundation of the Lowcountry INC Hilton Head | $16.9M | $16.7M | $89.9M |
| 19 | Michael J Mungo Foundation INC Irmo | $16.0M | $0 | $34.4M |
| 20 | Tmpc Nonprofit Holdings INC Columbia | $14.5M | $14.4M | $14.7M |
| 21 | United Way of the Midlands Columbia | $14.1M | $14.1M | $29.5M |
| 22 | Canal Charitable Foundation Greenville | $12.4M | $0 | $249K |
| 23 | National Christian Charitable Foundation INC Fort Mill | $12.1M | $3.7M | $16.0M |
| 24 | Vandy Charitable Foundation INC Georgetown | $11.8M | $0 | $15.4M |
| 25 | Ceres Foundation INC Charleston | $11.5M | $0 | $27.2M |
| 26 | We Take It for Charity INC Bluffton | $10.5M | $8.6M | $8.6M |
| 27 | Milliken & Company Charitable Foundation Spartanburg | $10.5M | $0 | $13.4M |
| 28 | Phillips Charitable Foundation INC Mt Pleasant | $9.5M | $0 | $25.0M |
| 29 | Dawn Laurel Foundation Clemson | $9.1M | $0 | $28.4M |
| 30 | Frances P Bunnelle Foundation Pawleys Isl | $8.7M | $2.1M | $46.6M |
| 31 | Bakala Foundation USA Greenville | $8.3M | $0 | $15.0M |
| 32 | Boys & Girls Clubs of the Midlands Columbia | $8.1M | $8.1M | $1.9M |
| 33 | Foothills Community Foundation Anderson | $7.9M | $7.9M | $46.0M |
| 34 | The Arras Foundation Lancaster | $7.6M | $0 | $77.2M |
| 35 | Able South Carolina Columbia | $7.5M | $7.5M | $4.7M |
| 36 | Mary Black Foundation INC Spartanburg | $7.5M | $0 | $87.1M |
| 37 | Benzon Foundation INC Landrum | $7.5M | $0 | $12.8M |
| 38 | Kuznik Charitable Foundation Charleston | $7.4M | $0 | $57.1M |
| 39 | Davis Family Foundation Greenwood | $7.4M | $0 | $21.2M |
| 40 | Prisma Health-upstate Foundation Greenville | $7.3M | $7.1M | $45.8M |
| 41 | Jewish Endowment Foundation of South Carolina N Charleston | $7.3M | $4.0M | $26.2M |
| 42 | Ocean View Memorial Foundation INC Myrtle Beach | $7.3M | $472K | $5.8M |
| 43 | New Morning Columbia | $7.1M | $7.1M | $4.6M |
| 44 | National Medal of Honor Center for Leadership Mt Pleasant | $6.8M | $6.8M | $7.2M |
| 45 | Campbell Young Leaders Greenville | $6.8M | $0 | $37.8M |
| 46 | United Way Association of South Carolina INC Columbia | $6.5M | $6.5M | $3.5M |
| 47 | The Jim Parke Foundation Seneca | $6.0M | $0 | $6.3M |
| 48 | Trident United Way INC N Charleston | $6.0M | $5.5M | $18.9M |
| 49 | Zvejnieks Foundation of South Carolina Elgin | $5.9M | $0 | $3.2M |
| 50 | Hasmukh and Gita Rama Foundation Greenville | $5.8M | $0 | $18.5M |