| 1 | American Endowment Foundation Hudson | $1.9B | $1.9B | $8.4B |
| 2 | Cleveland Foundation Cleveland | $1.4B | $302.8M | $3.3B |
| 3 | Columbus Foundation Columbus | $955.8M | $411.6M | $2.8B |
| 4 | Jack Joseph and Morton Mandel Supporting Foundation Cleveland | $760.4M | $161.6M | $3.2B |
| 5 | Jack Joseph and Morton Mandel Foundation Cleveland | $401.8M | $0 | $3.6B |
| 6 | United Way of Greater Cincinnati Cincinnati | $369.9M | $12.1M | $83.0M |
| 7 | Greater Cincinnati Foundation Cincinnati | $355.7M | $183.7M | $1.0B |
| 8 | Independent Charitable Gift Fund Hudson | $198.3M | $198.3M | $575.4M |
| 9 | University of Cincinnati Foundation Cincinnati | $187.4M | $177.9M | $904.7M |
| 10 | Jewish Federation of Cleveland Cleveland | $172.6M | $138.7M | $597.8M |
| 11 | Johnson Charitable Gift Fund Cincinnati | $165.6M | $94.5M | $383.4M |
| 12 | Millstone Fund Cincinnati | $153.0M | $0 | $235.1M |
| 13 | Akron Community Foundation Akron | $141.9M | $20.3M | $305.5M |
| 14 | Howley Foundation Ua 05192016 Cleveland | $111.9M | $0 | $131.9M |
| 15 | Columbus Jewish Foundation Columbus | $100.2M | $34.5M | $184.2M |
| 16 | Milliron Foundation Mansfield | $89.5M | $0 | $118.0M |
| 17 | Robert and Adele Schiff Family Foundation INC Cincinnati | $84.5M | $0 | $223.3M |
| 18 | The Lozick Family Foundation Pepper Pike | $82.7M | $0 | $278.7M |
| 19 | Stark Community Foundation INC Canton | $81.3M | $38.5M | $406.0M |
| 20 | The Schiewetz Foundation INC Moraine | $75.2M | $0 | $88.5M |
| 21 | Siemer Family Foundation Columbus | $75.1M | $59.7M | $76.8M |
| 22 | Young Mens Christian Association of Greater Cincinnati Cincinnati | $73.3M | $45.8M | $102.0M |
| 23 | Hamilton Community Foundation INC Hamilton | $65.7M | $31.6M | $167.5M |
| 24 | Dayton Foundation Dayton | $65.7M | $65.6M | $649.6M |
| 25 | Robert F Wolfe & Edgar T Wolfe Foundation Columbus | $65.0M | $9.2M | $474.7M |
| 26 | The Findlay-hancock County Community Foundation Findlay | $60.0M | $31.0M | $195.0M |
| 27 | Osteopathic Heritage Foundation Dublin | $57.1M | $0 | $301.9M |
| 28 | Wayne County Community Foundation Wooster | $56.9M | $18.9M | $156.4M |
| 29 | Foundation for Appalachian Ohio Nelsonville | $56.4M | $26.1M | $128.1M |
| 30 | Scripps-howard Foundation Cincinnati | $51.5M | $0 | $69.4M |
| 31 | Judson Foundation Cleveland | $51.4M | $5.0M | $39.0M |
| 32 | Richland County Foundation of Mansfield Mansfield | $49.3M | $20.4M | $228.4M |
| 33 | Licking County Foundation Newark | $44.6M | $44.6M | $163.6M |
| 34 | The Frances R Luther Charitable Trust Cincinnati | $44.3M | $0 | $53.1M |
| 35 | Randi H and Charles L Wien Family Foundation Beachwood | $41.8M | $0 | $795K |
| 36 | Toledo Community Foundation Toledo | $40.9M | $40.8M | $246.9M |
| 37 | Wilson Sheehan Foundation Springfield | $37.4M | $0 | $65.7M |
| 38 | The Humble Heart - Gentle Soul Foundation Parma | $36.5M | $0 | $57.1M |
| 39 | Jewish Federation of Cincinnati Cincinnati | $36.2M | $33.9M | $192.4M |
| 40 | Community Foundation of Lorain County Elyria | $35.9M | $7.6M | $167.9M |
| 41 | Troy Foundation Troy | $35.7M | $13.5M | $159.1M |
| 42 | Dever Family Foundation West Chester | $34.4M | $0 | $38.0M |
| 43 | Siemer Institute Columbus | $34.4M | $19.4M | $23.7M |
| 44 | Christ Foundation Hartville | $34.4M | $0 | $71.1M |
| 45 | Helen C Cole Tr Cleveland | $33.8M | $0 | $24.7M |
| 46 | Knox County Foundation Mount Vernon | $33.7M | $11.7M | $116.2M |
| 47 | Ohio Shared Information Services INC Cincinnati | $33.1M | $33.1M | $11.2M |
| 48 | Ronald and Florence Koetters Foundation Cincinnati | $32.2M | $0 | $30.8M |
| 49 | Tournaments for Charity Dublin | $32.0M | $31.9M | $6.6M |
| 50 | Margaret Clark Morgan Foundation Hudson | $31.6M | $0 | $111.0M |