| 1 | Anne Ray Foundation Eden Prairie | $3.0B | $153.1M | $5.0B |
| 2 | Margaret a Cargill Foundation Eden Prairie | $2.0B | $0 | $3.3B |
| 3 | McKnight Foundation Minneapolis | $955.4M | $0 | $2.7B |
| 4 | Thrivent Charitable Impact & Investing Minneapolis | $863.6M | $264.4M | $939.7M |
| 5 | Saint Paul & Minnesota Foundation Saint Paul | $562.0M | $161.0M | $1.6B |
| 6 | Minneapolis Foundation Minneapolis | $331.5M | $193.0M | $1.2B |
| 7 | Catholic Community Foundation of Minnesota Minnesota | $266.8M | $107.3M | $751.7M |
| 8 | Otto Bremer Trust Saint Paul | $171.6M | $0 | $1.4B |
| 9 | Car Donation Foundation St. Louis Park | $145.6M | $56.2M | $11.3M |
| 10 | Cummins Family Foundation Plymouth | $141.0M | $0 | $61.0M |
| 11 | Wells Fargo Foundation Minneapolis | $137.3M | $0 | $12.2M |
| 12 | The Richard M Schulze Family Foundation Minneapolis | $122.0M | $0 | $218.3M |
| 13 | Sauer Family Foundation Saint Paul | $102.3M | $0 | $61.4M |
| 14 | Slaggie Family Foundation Winona | $100.6M | $0 | $101.0M |
| 15 | Ghr Foundation Minneapolis | $81.8M | $0 | $1.1B |
| 16 | Charles K Blandin Foundation Grand Rapids | $72.3M | $0 | $506.3M |
| 17 | Goodman Family Operating Foundation Chaska | $72.1M | $0 | $356.4M |
| 18 | Joyful Noise Charitable Foundation Minneapolis | $66.8M | $0 | $213.4M |
| 19 | Nexus Community Partners Saint Paul | $66.6M | $5.5M | $46.6M |
| 20 | Minneapolis Jewish Federation St. Louis Park | $64.7M | $45.1M | $243.6M |
| 21 | Communitygiving Saint Cloud | $63.8M | $46.2M | $282.6M |
| 22 | Huang Chen Foundation INC Minneapolis | $50.8M | $0 | $5.4M |
| 23 | The Mortenson Family Foundation Minneapolis | $49.8M | $0 | $141.8M |
| 24 | Kaena Foundation Minneapolis | $45.3M | $0 | $95.4M |
| 25 | Greater Twin Cities United Way Minneapolis | $43.8M | $42.8M | $140.9M |
| 26 | The Hormel Foundation Austin | $43.2M | $40.8M | $1.2B |
| 27 | Lenzmeier Family Foundation Minneapolis | $41.6M | $0 | $28.1M |
| 28 | David and Janis Larson Foundation Minneapolis | $40.8M | $0 | $139.8M |
| 29 | Chorzempa Family Foundation Minneapolis | $39.5M | $0 | $29.2M |
| 30 | Ihle Family Foundation Saint Paul | $38.7M | $0 | $59.0M |
| 31 | The Curtis L Carlson Family Foundation Minnetonka | $37.6M | $0 | $285.7M |
| 32 | The Green Fern Foundation Minneapolis | $37.6M | $0 | $105.2M |
| 33 | Guilder Foundation Minneapolis | $37.4M | $0 | $101.6M |
| 34 | Nmdp Foundation Minneapolis | $34.3M | $24.3M | $18.4M |
| 35 | Community Charities of Minnesota Mankato | $34.0M | $2.8M | $1.2M |
| 36 | Womens Foundation of Minnesota Minneapolis | $33.5M | $9.1M | $39.4M |
| 37 | Larry and Sharon Larson Charitable Foundation Roseau | $31.2M | $0 | $34.5M |
| 38 | Northland Foundation Duluth | $30.9M | $14.0M | $124.7M |
| 39 | Peter J King Family Foundation Golden Valley | $30.8M | $0 | $68.9M |
| 40 | Kendrick B Melrose Family Foundation Plymouth | $30.6M | $0 | $49.2M |
| 41 | Sibley Medical Center Arlington | $30.0M | $25.0M | $40.7M |
| 42 | Frechette Family Foundation Minneapolis | $29.9M | $0 | $165.5M |
| 43 | Lakeville Hockey Association Lakeville | $27.4M | $2.2M | $1.6M |
| 44 | West Central Initiative Fergus Falls | $25.6M | $16.0M | $96.5M |
| 45 | Lloyd K Johnson Foundation Duluth | $24.0M | $0 | $31.0M |
| 46 | Propel Nonprofits Minneapolis | $23.0M | $23.0M | $61.7M |
| 47 | Best Buy Foundation Richfield | $22.4M | $0 | $59.2M |
| 48 | Cross Works Foundation St. Joseph | $21.4M | $0 | $64.0M |
| 49 | Tara Health Foundation Minneapolis | $21.2M | $0 | $34.5M |
| 50 | Pohlad Family Foundation Minneapolis | $21.2M | $0 | $76.4M |