| 1 | Bank of America Charitable Gift Fund Boston | $3.2B | $1.7B | $5.1B |
| 2 | Bny Mellon Charitable Gift Fund Boston | $1.3B | $284.9M | $2.0M |
| 3 | The US Charitable Gift Trust Boston | $910.5M | $430.9M | $2.2B |
| 4 | Flatley Foundation Braintree | $826.0M | $0 | $691.0M |
| 5 | Boston Foundation INC Boston | $595.3M | $210.4M | $1.9B |
| 6 | Combined Jewish Philanthropies of Greater Boston INC Boston | $518.9M | $317.7M | $2.3B |
| 7 | Cummings Foundation INC Woburn | $485.0M | $0 | $2.2B |
| 8 | Mathworks Foundation INC Natick | $330.4M | $0 | $424.4M |
| 9 | Barr Foundation Boston | $276.5M | $0 | $1.9B |
| 10 | The Mellen Charitable Foundation INC Boston | $225.5M | $0 | $307.9M |
| 11 | Yawkey Foundation II Westwood | $215.1M | $0 | $467.4M |
| 12 | Lynch Foundation Boston | $214.1M | $0 | $146.8M |
| 13 | Broad Reach Foundation Boston | $162.9M | $0 | $263.5M |
| 14 | Amelia Peabody Foundation Topsfield | $140.5M | $0 | $165.5M |
| 15 | Fiduciary Charitable Foundation Boston | $125.1M | $61.1M | $112.2M |
| 16 | Mira Charitable Foundation Boston | $107.9M | $0 | $82.2M |
| 17 | The Grantham Foundation for the Protection of the Environment Boston | $104.8M | $0 | $613.2M |
| 18 | Liberty Mutual Foundation INC Boston | $101.7M | $0 | $46.1M |
| 19 | Peter and Ann Lambertus Family Foundation INC Norwood | $96.9M | $0 | $297.9M |
| 20 | The American University of Greece Foundation Boston | $96.7M | $26.9M | $267.4M |
| 21 | Klarman Family Foundation Boston | $95.4M | $0 | $713.2M |
| 22 | Adelson Family Foundation Needham | $88.0M | $0 | $21.0M |
| 23 | Flock INC Boston | $86.2M | $0 | $25.9M |
| 24 | Eileen Patricia Sullivan Roche Foundation Boston | $85.8M | $0 | $41.9M |
| 25 | Cummings Foundation Grants INC Woburn | $82.6M | $0 | $258.2M |
| 26 | Jeremy and Hannelore Grantham Environmental Trust Boston | $81.9M | $74.7M | $467.7M |
| 27 | Greater Worcester Community Foundation INC Worcester | $78.7M | $14.8M | $227.4M |
| 28 | Tavitian Foundation II INC Stockbridge | $76.9M | $0 | $68.1M |
| 29 | United Way of Massachusetts Bay INC Boston | $76.8M | $48.5M | $65.8M |
| 30 | Pdb Foundation Cambridge | $75.7M | $0 | $80.1M |
| 31 | Whitehead Foundation INC Lenox | $74.8M | $0 | $48.9M |
| 32 | James S McDonnell Family Foundation INC Lincoln | $72.6M | $0 | $131.1M |
| 33 | Linde Family Foundation Boston | $72.0M | $0 | $214.9M |
| 34 | Jerome Lyle Rappaport Charitable Foundation Burlington | $68.0M | $0 | $98.9M |
| 35 | Community Foundation of Western Massachusetts Springfield | $67.9M | $37.1M | $292.1M |
| 36 | Schooner Foundation Boston | $64.8M | $0 | $253.7M |
| 37 | One8 Foundation Boston | $64.5M | $0 | $401.1M |
| 38 | China Medical Board INC Cambridge | $60.7M | $0 | $337.2M |
| 39 | Wellington Management Foundation Boston | $60.7M | $11.8M | $46.5M |
| 40 | Mosakowski Family Charitable Foundation Swampscott | $60.3M | $0 | $109.0M |
| 41 | Massmutual Foundation INC Springfield | $58.9M | $0 | $34.3M |
| 42 | Supreme Council Benevolent Foundation Lexington | $56.4M | $1.8M | $110.5M |
| 43 | The Berkshire Taconic Community Foundation INC Sheffield | $55.0M | $25.4M | $251.8M |
| 44 | Knopf Family Foundation INC Wakefield | $50.4M | $0 | $58.3M |
| 45 | Hunt Street Fund INC Needham | $50.3M | $0 | $101.6M |
| 46 | Chleck Family Foundation INC West Newton | $49.6M | $0 | $50.0M |
| 47 | Pepita Foundation INC Sheffield | $48.5M | $0 | $50.9M |
| 48 | Salem Foundation Boston | $48.4M | $0 | $72.2M |
| 49 | Provision Ministry INC Westborough | $47.8M | $47.8M | $1.9M |
| 50 | Amelia Peabody Charitable Fund Trs Boston | $47.2M | $0 | $121.5M |