| 1 | Great Plains Tribal Leaders Health Board Rapid City | $127.1M | $127.1M | $195.5M |
| 2 | Lewis & Clark Behavioral Health Services INC Yankton | $24.8M | $24.8M | $28.8M |
| 3 | Southeastern Behavioral Healthcare Sioux Falls | $18.7M | $18.7M | $12.6M |
| 4 | McCrossan Boys Ranch Sioux Falls | $10.7M | $10.6M | $38.7M |
| 5 | Dakota Counseling Institute INC Mitchell | $8.2M | $8.2M | $5.8M |
| 6 | Sesdac INC Vermillion | $7.6M | $7.6M | $9.0M |
| 7 | Capital Area Counseling Service INC Pierre | $7.6M | $7.6M | $15.1M |
| 8 | Northeastern Mental Health Center Aberdeen | $7.0M | $6.9M | $8.6M |
| 9 | Carroll Institute Sioux Falls | $6.5M | $6.5M | $9.1M |
| 10 | East Central Mental Health & Chemical Dependency Center Brookings | $4.2M | $4.0M | $4.2M |
| 11 | Addiction Recovery Centers of the Black Hills Rapid City | $2.1M | $2.1M | $2.5M |
| 12 | Three Rivers Mental Health and Chemical Dependency Center Lemmon | $1.9M | $1.9M | $3.0M |
| 13 | Sioux Empire Triage Center Sioux Falls | $1.7M | $1.7M | $4.5M |
| 14 | Face It Together INC Sioux Falls | $1.5M | $1.5M | $219K |
| 15 | Lost and Found Association Sioux Falls | $1.5M | $1.5M | $357K |
| 16 | Oaye Luta Okolakiciye Rapid City | $883K | $883K | $414K |
| 17 | Lakota Youth Development Herrick | $815K | $815K | $551K |
| 18 | Northeastern Mental Health Foundation Aberdeen | $646K | $132K | $1.4M |
| 19 | Sacred Mountain Retreat Center INC Deadwood | $643K | $529K | $101K |
| 20 | Objective Zero Foundation Sioux Falls | $540K | $540K | $447K |
| 21 | Washed Clean Addiction and Recovery Ministries Sioux Falls | $465K | $465K | $1.4M |
| 22 | Dakota Drug and Alcohol Prevention INC Sioux Falls | $239K | $239K | $9K |
| 23 | Healing Hope Ministries INC Alcester | $168K | $167K | $438K |
| 24 | South Dakota Council of Community Behavioral Health INC Pierre | $158K | $158K | $28K |
| 25 | Hope House INC Huron | $156K | $156K | $114K |
| 26 | Reflections Recovery Home INC Redfield | $82K | $82K | $20K |
| 27 | Communities Against Violence and Abuse Lemmon | $76K | $76K | $87K |
| 28 | T&c Legacy Foundation Dakota Dunes | $33K | $22K | $16K |
| 29 | Medicine Voice Healing Center Hot Springs | $0 | $0 | $0 |
| 30 | Family Services Center Spearfish | $0 | $0 | $0 |
| 31 | Serenity Incorporated Sturgis | $0 | $0 | $0 |
| 32 | Revival Club Sioux Falls | $0 | $0 | $0 |
| 33 | Riding Through Box Elder | $0 | $0 | $0 |
| 34 | Rooted 23 Mitchell | $0 | $0 | $0 |
| 35 | Cptsd Global Foundation Sioux Falls | $0 | $0 | $0 |
| 36 | Faith Fitness Freedom Recovery Program Spearfish | $0 | $0 | $0 |
| 37 | Cy Church Memorial Foundation Rapid City | $0 | $0 | $0 |
| 38 | Anthony Baker Lives on Foundation Rapid City | $0 | $0 | $0 |
| 39 | Turquoise Tiospaye Martin | $0 | $0 | $0 |
| 40 | Thanka Tatanka Rapid City | $0 | $0 | $0 |
| 41 | Walking in Grace INC Rapid City | $0 | $0 | $0 |
| 42 | Carsten Memorial Foundation Lead | $0 | $0 | $0 |
| 43 | Yankton Area Mental Wellness Yankton | $0 | $0 | $0 |
| 44 | Central Dakota Sexual Assault Response Team Mitchell | $0 | $0 | $0 |
| 45 | Alano Society of Custer INC Custer | $0 | $0 | $0 |
| 46 | From the H E a R T INC Sioux Falls | $0 | $0 | $0 |
| 47 | Madison Alano Society INC Madison | $0 | $0 | $0 |
| 48 | Ptsd Support Group INC St. Lawrence | $0 | $0 | $0 |
| 49 | New Trails Ministry Custer | $0 | $0 | $0 |
| 50 | Recovery Intervention Support Education Custer | $0 | $0 | $0 |