| 1 | Guthrie Risk Retention Group Charleston | $80.9M | $13.8M | $53.9M |
| 2 | Musc Affiliate Physicians Charleston | $59.8M | $59.8M | $11.1M |
| 3 | Lexington-richland Alcohol & Drug Abuse Council INC Columbia | $12.4M | $12.4M | $17.8M |
| 4 | Windwood Farm Home for Children INC Awendaw | $7.6M | $7.4M | $5.9M |
| 5 | Florence County Commission on Alcohol and Drug Abuse Florence | $7.1M | $7.1M | $6.7M |
| 6 | Forrester Center for Behavioral Health INC Spartanburg | $5.8M | $5.3M | $17.5M |
| 7 | Trinity Wellness Foundation Marion | $5.1M | $5.1M | $9.4M |
| 8 | South Carolina Infant Young Child Mental Health Association Charleston | $4.6M | $4.6M | $2.2M |
| 9 | Alpha Center Camden | $4.3M | $4.2M | $9.4M |
| 10 | Ernest E Kennedy Center INC Moncks Corner | $3.9M | $3.9M | $4.2M |
| 11 | Sumter County Commission on Alcohol and Drug Abuse Sumter | $3.3M | $3.3M | $9.7M |
| 12 | Modern Minds Mt Pleasant | $2.9M | $2.9M | $1.6M |
| 13 | Greenwood-edgefield-mccormick- Abbeville Comm on Alc & Drug Abuse Greenwood | $2.8M | $2.8M | $5.2M |
| 14 | Gateway House INC Greenville | $2.6M | $2.6M | $9.2M |
| 15 | Fair Play Camp School INC Westminster | $2.6M | $2.1M | $5.0M |
| 16 | Mental Health Association of Greenville County Greenville | $2.2M | $2.2M | $4.9M |
| 17 | Courage Center Lexington | $2.1M | $2.1M | $1.1M |
| 18 | Barnwell County Commission on Alchohol and Drug Abuse Barnwell | $2.0M | $2.0M | $2.9M |
| 19 | First Presbyterian Church Counseling Center INC Columbia | $2.0M | $2.0M | $346K |
| 20 | Pathways to Healing Columbia | $1.8M | $1.7M | $2.7M |
| 21 | Salvation Oaks Recovery Community INC Greenwood | $1.6M | $1.6M | $1.1M |
| 22 | Center for Counseling & Wellness North Myrtle Beach | $1.6M | $1.6M | $340K |
| 23 | Christ Freedom Home Taylors | $1.5M | $1.5M | $21K |
| 24 | Mental Health America of South Carolina Cayce | $1.5M | $1.5M | $5.8M |
| 25 | Chester County Commission on Alcohol and Drug Abuse Chester | $1.5M | $1.5M | $1.9M |
| 26 | Behavioral Health Services of South Carolina INC Irmo | $1.4M | $1.4M | $273K |
| 27 | Clarendon County Commission on Alcohol & Drug Abuse Manning | $1.4M | $1.4M | $3.4M |
| 28 | Georgetown County Alcohol and Drug Abuse Commission Georgetown | $1.2M | $1.2M | $531K |
| 29 | First Light Anderson | $1.2M | $1.2M | $580K |
| 30 | Wake Up Carolina Mt Pleasant | $1.0M | $970K | $409K |
| 31 | Seeds of Life INC Mt Pleasant | $961K | $893K | $138K |
| 32 | Any Lengths Recovery INC Sumter | $857K | $856K | $1.2M |
| 33 | Lowcountry Biblical Counseling Center N Charleston | $833K | $829K | $160K |
| 34 | Mental Health America of South Carolina Bluffton | $766K | $511K | $66K |
| 35 | Work in Progress INC Columbia | $712K | $712K | $470K |
| 36 | Womens Shelter Columbia | $671K | $356K | $1.9M |
| 37 | Sammys Mission Simpsonville | $665K | $665K | $877K |
| 38 | Genesis Center Sumnter | $643K | $643K | $0 |
| 39 | Potter House Recovery Florence | $613K | $613K | $125K |
| 40 | Shared Services Alliance Greenville | $586K | $586K | $183K |
| 41 | Palmetto Foundation for Prevention and Recovery INC Chapin | $539K | $539K | $609K |
| 42 | Alabaster House Easley | $490K | $490K | $800K |
| 43 | The Prodigals Home Jonesville | $477K | $477K | $1.3M |
| 44 | Overflow Foundation LLC Aiken | $476K | $476K | $423K |
| 45 | New Beginning of Charleston INC Summerville | $456K | $456K | $327K |
| 46 | Still Worthy INC Johns Island | $455K | $455K | $30K |
| 47 | Palmetto Recovery of Charleston Charleston | $450K | $450K | $737K |
| 48 | Barnabas Horse Foundation Murrells Inlt | $436K | $424K | $341K |
| 49 | Defenders for Children Greenville | $434K | $434K | $618K |
| 50 | Shalom House Ministries INC Belton | $429K | $418K | $255K |