| 1 | The Medical University of South Carolina Foundation Charleston | $441.3M | $88.9M | $817.0M |
| 2 | Greenwood Genetic Center INC Greenwood | $31.7M | $31.7M | $29.1M |
| 3 | Musc Foundation for Research Development Charleston | $5.6M | $5.6M | $4.7M |
| 4 | Lowcountry Center for Veterans Research Charleston | $3.6M | $3.6M | $3.6M |
| 5 | Cure Sanfilippo Foundation Columbia | $3.1M | $2.8M | $13.9M |
| 6 | The Hawkins Foundation Greenville | $898K | $898K | $767K |
| 7 | Clinical Biotechnology Research Institute at Rsfh Charleston | $585K | $585K | $84K |
| 8 | David M Carmines Memorial Foundation Hilton Head | $566K | $190K | $172K |
| 9 | Dorn Research Institute Columbia | $487K | $487K | $1.1M |
| 10 | Phillips-amick Foundation for Cancer Research Greenville | $457K | $457K | $41K |
| 11 | Association of Cancer Center Administrators Charleston | $408K | $408K | $170K |
| 12 | Trs Cancer Fighters INC N Myrtle Bch | $281K | $281K | $252K |
| 13 | Closing the Gap in Health Care INC North Charleston | $241K | $195K | $61K |
| 14 | Southeastern Regional Genetics Group INC Lancaster | $193K | $193K | $291K |
| 15 | Challenge to Conquer Cancer Greenville | $180K | $180K | $3K |
| 16 | Aiken Womens Heart Board Aiken | $154K | $138K | $11K |
| 17 | Bartels Family Foundation Aiken | $128K | $0 | $455K |
| 18 | Dylan Adams Endowment Hartsville | $127K | $86K | $98K |
| 19 | Council on Chiropractic Guidelines & Practice Parameters Lexington | $124K | $124K | $222K |
| 20 | Rdh12 Fund for Sight Boiling Spgs | $107K | $105K | $1.7M |
| 21 | Technology Accelerator Company Charleston | $103K | $17K | $3.2M |
| 22 | Saras Cure Charleston | $97K | $92K | $52K |
| 23 | South Carolina Advocates for Epilepsy Goose Creek | $60K | $43K | $3K |
| 24 | Emily Brown Kocis Celebration of Life Group Greer | $57K | $38K | $1 |
| 25 | Drake Rayden Foundation Simpsonville | $42K | $42K | $2K |
| 26 | Melanated Melon Fort Mill | $38K | $14K | $2K |
| 27 | Carolina Orthopaedic Research Foundation Greenville | $29K | $0 | $51K |
| 28 | Health and Welfare Foundation Aiken | $20K | $20K | $29K |
| 29 | Joanne W Charles Memorial Fund Summerton | $18K | $18K | $7K |
| 30 | Braelyn Aubrey Foundation Lexington | $7K | $0 | $4K |
| 31 | Terminate Cancer Foundation Hilton Head | $5K | $0 | $2K |
| 32 | Education and Research Foundation Columbia | $1K | $0 | $12K |
| 33 | Shane Edward Tanzosh Arvc Heart Foundation INC N Myrtle Bch | $50 | $50 | $18K |
| 34 | Tree Tops You Got This Club Lancaster | $1 | $0 | $1 |
| 35 | Transnational Alliance for Genetic Counseling INC Columbia | $0 | $0 | $0 |
| 36 | Leonard Wood Memorial for the Eradication of Leprosy and the Greenville | $0 | $0 | $0 |
| 37 | Share Our Suzy Columbia | $0 | $0 | $0 |
| 38 | Foundation for Pediatric Health Goose Creek | $0 | $0 | $0 |
| 39 | Chase After a Cure Summerville | $0 | $0 | $0 |
| 40 | Society of Ultrasound in Medical Education Blythewood | $0 | $0 | $0 |
| 41 | Mastokids INC Drayton | $0 | $0 | $0 |
| 42 | Reconstruct the Runway Spartanburg | $0 | $0 | $0 |
| 43 | Jacks Pack Chapin | $0 | $0 | $0 |
| 44 | Blakley Foundation Fort Mill | $0 | $0 | $0 |
| 45 | Woodstock Institute for Science & the Humanities Clemson | $0 | $0 | $0 |
| 46 | Neuro Pineal Research Foundation Florence | $0 | $0 | $0 |
| 47 | Genesis Hope Foundation Spartanburg | $0 | $0 | $0 |
| 48 | Rockers for Knockers INC Mount Pleasant | $0 | $0 | $14K |
| 49 | North American Burn Society INC Spartanburg | $0 | $0 | $0 |
| 50 | Zucker Institute for Applied Neurosciences INC Charleston | $0 | $0 | $0 |