| 1 | American Association for Cancer Research Philadelphia | $196.8M | $137.4M | $291.8M |
| 2 | Greater Delaware Valley Society of Transplant Surgeons Philadelphia | $163.8M | $152.9M | $152.2M |
| 3 | The Wistar Institute of Anatomy and Biology Philadelphia | $132.6M | $93.1M | $424.9M |
| 4 | Institute for Cancer Research Philadelphia | $102.2M | $98.0M | $182.7M |
| 5 | Philadelphia Fight Philadelphia | $61.3M | $60.6M | $23.2M |
| 6 | Nsabp Foundation INC Pittsburgh | $47.9M | $37.6M | $112.2M |
| 7 | Eye & Ear Foundation INC Pittsburgh | $42.0M | $16.4M | $67.0M |
| 8 | Transcelerate Biopharma INC West Conshohocken | $38.6M | $38.6M | $55.3M |
| 9 | Centre County Cancer Center State College | $35.4M | $35.4M | $9.0M |
| 10 | Monell Chemical Senses Center Philadelphia | $34.3M | $20.7M | $43.9M |
| 11 | Nrg Oncology Foundation INC Pittsburgh | $33.9M | $33.9M | $8.5M |
| 12 | Wills Eye Ophthalmology Clinic INC Philadelphia | $32.0M | $32.0M | $11.9M |
| 13 | Donald Guthrie Foundation Sayre | $28.3M | $10.0M | $77.8M |
| 14 | The Association for Frontotemporal Degeneration Kng of Prussa | $24.8M | $14.4M | $60.1M |
| 15 | Friedreichs Ataxia Research Alliance Fara Downingtown | $15.0M | $13.1M | $6.9M |
| 16 | Baruch S Blumberg Institute Doylestown | $15.0M | $14.5M | $10.5M |
| 17 | Coalition of Cancer Cooperative Groups Philadelphia | $12.8M | $12.8M | $22.4M |
| 18 | National Disease Research Interchange Philadelphia | $11.3M | $11.3M | $7.1M |
| 19 | Ao North America Charitable Fund Wayne | $9.5M | $4.0M | $21.4M |
| 20 | Surgical Associates Research and Educational Foundation One Childre Philadelphia | $8.9M | $936K | $4.3M |
| 21 | Lung Cancer Research Foundation Philadelphia | $7.8M | $7.4M | $7.5M |
| 22 | American Society of Regional Anesthesia Surgery Obstetrics and Pittsburgh | $7.7M | $4.9M | $19.4M |
| 23 | Breastcancer Org Ardmore | $5.8M | $5.8M | $4.7M |
| 24 | Philadelphia Research & Education Foundation Philadelphia | $5.3M | $2.2M | $3.3M |
| 25 | The Naspghan Foundation Ambler | $4.9M | $2.3M | $8.2M |
| 26 | Croi Foundation Pittsburgh | $4.5M | $4.5M | $7.6M |
| 27 | Nccn Foundation Plymouth Mtng | $3.9M | $3.9M | $9.5M |
| 28 | Special Friends Foundation INC Drexel Hill | $3.8M | $3.8M | $4.9M |
| 29 | For Petes Sake Cancer Respite Foundation Plymouth Mtng | $3.8M | $2.7M | $8.9M |
| 30 | Fox Chase Cancer Center Foundation Philadelphia | $2.5M | $2.5M | $58.2M |
| 31 | Sbarro Health Research Organization INC Philadelphia | $2.4M | $2.3M | $3.2M |
| 32 | The Leonard and Madlyn Abramson Family Cancer Research Institute Philadelphia | $2.3M | $2.2M | $13.9M |
| 33 | National Blood Clot Alliance Philadelphia | $1.8M | $1.8M | $1.3M |
| 34 | Kidney Cancer Coalition INC Philadelphia | $1.7M | $1.7M | $2.0M |
| 35 | American Foundation for Children with Aids INC Harrisburg | $1.7M | $1.7M | $696K |
| 36 | Als Hope Foundation Ft Washington | $1.4M | $1.2M | $707K |
| 37 | Emily Whitehead Foundation Philipsburg | $1.2M | $955K | $733K |
| 38 | Simons Fund Conshohocken | $1.1M | $664K | $480K |
| 39 | Heme Foundation Walnutport | $979K | $342K | $288K |
| 40 | Global Vitiligo Foundation Mechanicsburg | $918K | $918K | $535K |
| 41 | Childrens Oncology Group Foundation Philadelphia | $916K | $916K | $21.4M |
| 42 | Cardiovascular Medical Research and Education Fund INC King of Prussia | $911K | $0 | $511K |
| 43 | Commonwealth Housing Legal Services Philadelphia | $849K | $849K | $1.0M |
| 44 | Association for Pathology Informatics INC Hermitage | $722K | $722K | $432K |
| 45 | Bee Foundation Wayne | $718K | $420K | $799K |
| 46 | The Ryr-1 Foundation Pittsburgh | $682K | $682K | $2.7M |
| 47 | Oc87 INC Philadelphia | $655K | $0 | $118K |
| 48 | Eastern Pennsylvania Bleeding Disorders Foundation West Chester | $628K | $590K | $2.9M |
| 49 | Twist Out Cancer Philadelphia | $627K | $627K | $172K |
| 50 | Distance Learning Center INC Philadelphia | $532K | $532K | $11K |