| 1 | Health Research Incorporated Elizabeth Wood Menands | $1.8B | $1.1B | $845.1M |
| 2 | Michael J Fox Foundation for Parkinsons Research New York | $1.5B | $505.3M | $439.0M |
| 3 | Licr Fund INC New York | $449.4M | $79.0M | $1.9B |
| 4 | Public Health Solutions New York | $271.4M | $271.2M | $148.3M |
| 5 | The Feinstein Institute for Medical Research Westbury | $203.7M | $163.3M | $229.3M |
| 6 | Global Alliance for Tb Drug Development INC New York | $202.5M | $63.7M | $204.3M |
| 7 | Parkinsons Foundation INC New York | $171.9M | $84.2M | $62.7M |
| 8 | Cardiovascular Research Foundation New York | $79.2M | $68.9M | $87.5M |
| 9 | Research to Prevent Blindness Endowment Fund INC New York | $75.0M | $13.1M | $286.0M |
| 10 | Every Cure INC New York | $54.5M | $54.5M | $51.6M |
| 11 | Cancer Research Institute INC New York | $54.0M | $24.0M | $133.7M |
| 12 | The Foundation for Aids Research New York | $49.2M | $24.8M | $53.4M |
| 13 | International Brain Research Organization New York | $37.2M | $37.2M | $37.2M |
| 14 | Lupus Research Alliance INC New York | $31.5M | $18.6M | $93.3M |
| 15 | The International Academy of Hope New York | $27.7M | $27.7M | $67.4M |
| 16 | New York Stem Cell Foundation INC New York | $23.9M | $23.1M | $82.9M |
| 17 | Childrens Tumor Foundation New York | $20.9M | $19.7M | $30.7M |
| 18 | Winifred Masterson Burke Medical Research White Plains | $19.7M | $19.7M | $7.2M |
| 19 | Masonic Medical Research Laboratory Utica | $18.7M | $10.1M | $41.7M |
| 20 | Zachary and Elizabeth M Fisher Center for Alzheimers Research Foundation New York | $17.1M | $14.5M | $36.3M |
| 21 | Trudeau Institute INC Saranac Lake | $16.9M | $8.2M | $19.7M |
| 22 | Sanders Tri-institutional Therapeut Discovery Institute INC Co Weill C New York | $16.6M | $16.6M | $7.3M |
| 23 | American-italian Cancer Foundation New York | $15.2M | $2.9M | $6.9M |
| 24 | Advancium Health Network INC New York | $14.3M | $1.1M | $4.8M |
| 25 | Hereditary Disease Foundation New York | $14.0M | $7.9M | $22.0M |
| 26 | Jacobs Institute INC Buffalo | $12.5M | $12.5M | $7.4M |
| 27 | Football Research INC New York | $12.1M | $12.1M | $3.3M |
| 28 | Tisch Multiple Sclerosis Research Center of New York INC New York | $11.2M | $10.4M | $29.5M |
| 29 | Hauptman-woodward Medical Research Institute INC Buffalo | $11.0M | $11.0M | $27.6M |
| 30 | The Vilcek Foundation INC New York | $9.5M | $0 | $137.5M |
| 31 | Hearing Health Foundation New York | $8.5M | $4.7M | $14.3M |
| 32 | Cds Wolf Foundation INC Webster | $8.2M | $7.9M | $27.1M |
| 33 | Regenerative Research Foundation Albany | $7.0M | $7.0M | $9.0M |
| 34 | Cerebral Palsy Foundation INC New York | $7.0M | $4.7M | $2.8M |
| 35 | Research to Prevent Blindness INC New York | $6.9M | $6.8M | $27.3M |
| 36 | University of Tokyo New York Office INC New York | $5.7M | $2.7M | $21.1M |
| 37 | The Honorable Tina Brozman Foundation INC New York | $5.6M | $4.2M | $6.9M |
| 38 | Malmonides Research and Development Foundation Brooklyn | $5.6M | $907K | $22.5M |
| 39 | Healthcorps INC New York | $5.1M | $5.0M | $5.0M |
| 40 | Saint Pauls Autism Research & Training Academy College Point | $4.7M | $4.7M | $3.9M |
| 41 | T J Martell Foundation New York | $4.5M | $3.5M | $5.8M |
| 42 | Buffalo Prenatal-perinatal Network INC Buffalo | $4.4M | $4.3M | $2.1M |
| 43 | Dent Neurosciences Research Center INC Amherst | $4.3M | $4.0M | $5.6M |
| 44 | Clinical Research Associates LLC New York | $4.2M | $0 | $1.4M |
| 45 | Making Headway Foundation INC Chappaqua | $4.0M | $1.1M | $3.9M |
| 46 | Clinical Directors Network INC New York | $3.7M | $3.7M | $3.3M |
| 47 | Galien Foundation INC New York | $3.4M | $3.4M | $3.7M |
| 48 | Laniado Development Fund INC Brooklyn | $3.2M | $3.2M | $3.0M |
| 49 | Lymphatic Education & Research Network INC Le&rn New York | $3.1M | $1.8M | $4.0M |
| 50 | Richmond Medical Center Foundation INC Staten Island | $3.1M | $2.7M | $8.0M |