| 1 | Hennepin Healthcare Research Institute Minneapolis | $54.7M | $54.7M | $75.5M |
| 2 | Minneapolis Heart Institute Foundation Minneapolis | $27.7M | $23.6M | $74.5M |
| 3 | American Brain Foundation Minneapolis | $18.7M | $6.2M | $21.6M |
| 4 | Essentia Institute of Rural Health Duluth | $13.3M | $12.5M | $6.7M |
| 5 | American Neuromuscular Foundation Rochester | $10.5M | $2.8M | $9.6M |
| 6 | Center for Veterans Research and Education Minneapolis | $9.1M | $6.9M | $6.8M |
| 7 | Spring Point Project Minneapolis | $3.7M | $3.7M | $8.3M |
| 8 | Society of Vascular and Interventional Neurology Minneapolis | $2.9M | $2.7M | $2.3M |
| 9 | Pcd Ks Foundation Bloomington | $2.4M | $2.0M | $3.6M |
| 10 | International Society of Amyliodosis Burnsville | $2.3M | $2.3M | $2.5M |
| 11 | The American Foregut Society Minneapolis | $1.7M | $1.7M | $1.1M |
| 12 | Minnesota Ovarian Cancer Alliance INC Minneapolis | $1.6M | $1.5M | $1.7M |
| 13 | Karen Wyckoff Rein in Sarcoma Fridley | $1.5M | $577K | $1.1M |
| 14 | Randy Shaver Cancer Research and Community Fund Minnetonka | $1.5M | $1.4M | $353K |
| 15 | International Society for the Study of Womens Sexual Health Burnsville | $1.4M | $1.4M | $2.4M |
| 16 | Minnesota Colon and Rectal Foundation Minneapolis | $1.2M | $0 | $3.9M |
| 17 | Eagles Fifth District Cancer Telethon Rochester | $1.1M | $1.1M | $949K |
| 18 | Star Legacy Foundation Eden Prairie | $975K | $870K | $1.1M |
| 19 | Twin Cities Orthopedics Foundation Bloomington | $881K | $881K | $502K |
| 20 | Mille Lacs Area Health Foundation INC Onamia | $570K | $552K | $728K |
| 21 | Jack Jablonski Believe in Miracles Foundation New Brighton | $546K | $338K | $175K |
| 22 | Minneapolis Radiology Vascular Research Foundation Plymouth | $505K | $505K | $452K |
| 23 | Achieving Cures Together St. Louis Park | $477K | $441K | $236K |
| 24 | Meningitis Foundation Minneapolis | $464K | $464K | $451K |
| 25 | North American Specialized Coagulation Laboratory Association Rochester | $329K | $329K | $919K |
| 26 | International Union of Physiological Sciences Rochester | $304K | $304K | $965K |
| 27 | Flagella Vision Foundation Woodbury | $303K | $303K | $232K |
| 28 | North American Fetal Therapy Network INC Roseville | $231K | $193K | $571K |
| 29 | Fetal Heart Society INC Roseville | $215K | $215K | $516K |
| 30 | Mn Lions Childhood Cancer Foundation INC Duluth | $207K | $207K | $61K |
| 31 | Fools Five INC Lewiston | $199K | $173K | $259K |
| 32 | Super Herber Bros Foundation INC Rochester | $177K | $0 | $361K |
| 33 | Als Fundraiser Roseau | $161K | $119K | $104K |
| 34 | A Race Worth Winning-als INC Elko New Mrkt | $154K | $153K | $19K |
| 35 | Minnesota Eye Foundation Minnetonka | $146K | $146K | $120K |
| 36 | Particle Therapy Cooperative Group - North America INC Rochester | $145K | $145K | $229K |
| 37 | Arnold S Leonard Cancer Research Fund Crystal | $138K | $101K | $85K |
| 38 | Crush Als INC Cologne | $114K | $76K | $5K |
| 39 | X Out Ald INC Bloomington | $111K | $101K | $9K |
| 40 | Council of University Chairs of Obstetrics and Gynecology Burnsville | $108K | $108K | $797K |
| 41 | Rt Autism Awareness Foundation Rochester | $105K | $105K | $38K |
| 42 | Get Up Stand Up to Cure Paralysis Foundation Minnetonka | $105K | $90K | $203K |
| 43 | Twin Cities Heart Foundation Minneapolis | $86K | $86K | $970K |
| 44 | Cormick Scanlan Memorial Foundation Saint Paul | $80K | $80K | $63K |
| 45 | Lac Qui Parle Hope Network INC Madison | $79K | $79K | $286K |
| 46 | Susan and Maria Puppin Fund Bayport | $59K | $0 | $166K |
| 47 | Northern Plains Rural Surgical Society Minneapolis | $44K | $44K | $29K |
| 48 | Spiritwood Foundation Ely | $44K | $0 | $28K |
| 49 | Alabama Implant Study Group INC Twin Valley | $40K | $40K | $25K |
| 50 | Curing Alzheimers Disease Private Foundation INC Stillwater | $39K | $39K | $48K |