| 1 | Alliance for Clinical Trials in Oncology Foundation Chicago | $68.0M | $44.5M | $112.8M |
| 2 | Stanley Manne Childrens Research Institute Chicago | $63.1M | $63.1M | $134.9M |
| 3 | Brain Research Foundation Chicago | $22.0M | $4.0M | $22.3M |
| 4 | Michael Reese Research and Education Foundation Chicago | $21.6M | $2.6M | $15.7M |
| 5 | Oral and Maxillofacial Surgery Foundation Rosemont | $20.5M | $3.3M | $20.4M |
| 6 | Foundation of the American Society of Neuroradiology Oak Brook | $15.5M | $4.7M | $14.0M |
| 7 | Lungevity Foundation Chicago | $14.7M | $13.8M | $6.2M |
| 8 | Orthopaedic Research and Education Foundation Rosemont | $13.5M | $4.3M | $21.5M |
| 9 | Gateway for Cancer Research INC Chicago | $13.3M | $9.4M | $21.1M |
| 10 | Ada Foundation Chicago | $11.7M | $2.1M | $16.7M |
| 11 | Emily G Plumb Charitable Trust 02-40073 Chicago | $11.6M | $0 | $38.1M |
| 12 | Saem Research Foundation Des Plaines | $10.3M | $2.9M | $13.7M |
| 13 | Leukemia Research Foundation INC Northfield | $10.1M | $6.0M | $10.3M |
| 14 | Foundation for Anesthesia Education and Research Schaumburg | $9.2M | $3.8M | $32.8M |
| 15 | Ulta Beauty Charitable Foundation Bolingbrook | $9.0M | $9.0M | $3.0M |
| 16 | American Society for Transplantation & Cellular Therapy Chicago | $8.7M | $8.5M | $13.9M |
| 17 | American Burn Association INC Chicago | $8.3M | $7.1M | $7.1M |
| 18 | International Society for Stem Cell Research Evanston | $7.8M | $7.0M | $8.6M |
| 19 | Citizens United for Research in Epilepsy Chicago | $7.8M | $6.1M | $10.7M |
| 20 | American Academy of Sleep Medicine Foundation Darien | $7.2M | $3.3M | $18.2M |
| 21 | American Foundation for Surgery of the Hand Chicago | $7.1M | $4.3M | $41.4M |
| 22 | Chicago Association for Research and Education in Science Hines | $6.5M | $6.5M | $9.7M |
| 23 | The Foundation for Peripheral Neuropathy Glenview | $5.1M | $1.9M | $2.3M |
| 24 | Equal Hope Chicago | $5.0M | $4.9M | $5.6M |
| 25 | Orthopaedic Research Society Rosemont | $4.4M | $4.4M | $9.9M |
| 26 | Radiation Medicine Institute Arlington Hts | $4.4M | $4.4M | $3.9M |
| 27 | Gastro-intestinal Research Foundation INC Highland Park | $4.2M | $3.8M | $5.1M |
| 28 | Orthopaedic Foot & Ankle Foundation Schaumburg | $4.1M | $1.7M | $13.0M |
| 29 | Prairie Research and Education Cooperative Springfield | $4.0M | $4.0M | $5.0M |
| 30 | Dystonia Medical Research Foundation Chicago | $4.0M | $3.2M | $6.4M |
| 31 | Mpn Research Foundation Chicago | $4.0M | $3.6M | $8.0M |
| 32 | Partnership for Cures Chicago | $3.9M | $3.9M | $7.5M |
| 33 | Angelman Syndrome Foundation INC Aurora | $3.9M | $3.9M | $2.7M |
| 34 | Cancer Research Foundation Chicago | $3.9M | $1.2M | $10.2M |
| 35 | The Bancroft School Elgin | $3.1M | $3.1M | $6.5M |
| 36 | Neurosurgery Research and Education Foundation Rolling Meadows | $3.0M | $1.3M | $20.0M |
| 37 | Society for Cardiovascular East Dundee | $2.8M | $2.8M | $3.2M |
| 38 | Society of Urologic Oncology Schaumburg | $2.7M | $2.7M | $8.2M |
| 39 | Bear Necessities Pediatric Cancer Foundation Chicago | $2.3M | $1.5M | $2.4M |
| 40 | Brca Research & Cure Alliance Chicago | $2.3M | $0 | $1 |
| 41 | Cancer Research Foundation Chicago | $2.3M | $1.5M | $1.3M |
| 42 | Erase Ptsd Now Chicago | $2.2M | $2.1M | $1.4M |
| 43 | Pediatric Interventional Cardiacsymposium Foundation Chicago | $2.0M | $2.0M | $1.4M |
| 44 | Proton Collaborative Group INC Warrenville | $1.9M | $1.9M | $2.0M |
| 45 | Allsup Charitable Services INC Belleville | $1.8M | $0 | $76K |
| 46 | Hippocratic Cancer Research Foundation INC Wheeling | $1.8M | $939K | $567K |
| 47 | Musculoskeletal Tumor Society Schaumburg | $1.7M | $1.0M | $2.0M |
| 48 | A Just Harvest Chicago | $1.7M | $1.7M | $1.2M |
| 49 | Interstate Postgraduate Medical Association of North America Prospect Hts | $1.5M | $825K | $1.3M |
| 50 | Foundation for Physical Medicine and Rehabilitation Rosemont | $1.5M | $399K | $3.1M |