| 1 | Bliss Cares INC Orlando | $36.6M | $36.6M | $6.4M |
| 2 | Max Planck Florida Corporation Jupiter | $33.5M | $33.5M | $108.6M |
| 3 | Diabetes Research Institute Foundation INC Miami | $15.9M | $9.5M | $26.4M |
| 4 | Dolphins Cycling Challenge INC Miami Gardens | $14.6M | $14.6M | $5.8M |
| 5 | Papanicolaou Corps for Cancer Research INC Deerfield Bch | $13.3M | $5.0M | $4.8M |
| 6 | American College of Endocrinology INC Jacksonville | $11.8M | $10.5M | $6.7M |
| 7 | Dr Larry & Ann Laiks Charitable Tr Uad 31 Oct 2000 as Amended Sarasota | $8.4M | $0 | $18.4M |
| 8 | Roskamp Institute INC Sarasota | $6.8M | $6.8M | $9.9M |
| 9 | Tampa Va Research and Education Foundation INC Temple Terr | $5.4M | $5.2M | $4.9M |
| 10 | Walter J Gatti Foundation INC Melbourne | $4.7M | $0 | $1 |
| 11 | Macular Degeneration Association Sarasota | $4.6M | $4.6M | $7.8M |
| 12 | Foundation for Orthopaedic Research and Education INC Tampa | $4.3M | $4.3M | $1.2M |
| 13 | North Florida Foundation for Research and Education INC Gainesville | $4.2M | $4.2M | $6.2M |
| 14 | Ophthalmology Research Foundation INC Miami | $4.1M | $4.1M | $78.8M |
| 15 | Florida Breast Cancer Coalition Research Foundation Oviedo | $3.9M | $3.9M | $5.8M |
| 16 | Stasis Foundation Fort Lauderdale | $3.7M | $1.4M | $15.8M |
| 17 | Preeclampsia Foundation Melbourne | $3.5M | $3.0M | $3.1M |
| 18 | Dr Joseph P D Angleo Foundation Hallandle Bch | $2.7M | $0 | $4.5M |
| 19 | International Psoriasis Council Belleair Bluffs | $2.4M | $1.8M | $4.7M |
| 20 | University Foundation for Educationand Research INC Tampa | $2.3M | $605K | $2.2M |
| 21 | Runway to Hope INC Winter Park | $2.0M | $1.7M | $890K |
| 22 | Receptions for Research - the Greg Olsen Foundation INC Ft Lauderdale | $2.0M | $1.3M | $986K |
| 23 | Behavioral Science Research Institute INC Coral Gables | $1.9M | $1.9M | $1.2M |
| 24 | The Donna Foundation INC Atlantic Beach | $1.6M | $1.6M | $548K |
| 25 | Neurodegenerative Disease Research INC Reddick | $1.6M | $1.6M | $248K |
| 26 | Proton Therapy Consortia Jacksonville | $1.5M | $1.5M | $2.2M |
| 27 | Arthritis Research Institute of America INC Clearwater | $1.5M | $1.1M | $2.7M |
| 28 | Bay Pines Foundation INC Bay Pines | $1.5M | $1.5M | $2.0M |
| 29 | Pipers Angels Foundation INC Jupiter | $1.4M | $1.3M | $397K |
| 30 | International Brain Research Foundation INC Boca Raton | $1.4M | $1.4M | $74K |
| 31 | Torch Relay for Childrens Miracle Network INC Orlando | $1.3M | $1.3M | $4K |
| 32 | Phelan McDermid Syndrome Foundation Osprey | $1.3M | $1.3M | $2.1M |
| 33 | Resurgence Biomedical Sciences INC Ft Lauderdale | $1.3M | $1.3M | $547K |
| 34 | Morgan Pressel Foundation INC Boca Raton | $1.2M | $1.2M | $984K |
| 35 | American Society for Metabolic and Bariatric Surgery Foundation INC Newberry | $1.1M | $455K | $1.0M |
| 36 | Royal Dames of Cancer Research INC Ft Lauderdale | $1.1M | $814K | $78K |
| 37 | The Mark and Janice Gold Family Foundation INC Miami | $1.1M | $0 | $1.6M |
| 38 | Orphan Disease Pathway Project Miami Beach | $1.0M | $1.0M | $1.3M |
| 39 | Quality Independence INC Pt Charlotte | $932K | $932K | $38K |
| 40 | Brain Tumor Research Charity Stuart | $927K | $21K | $170K |
| 41 | Biostasis Technologies INC Ft Lauderdale | $868K | $868K | $396K |
| 42 | American Sudden Infant Death Syndrome Institute INC Naples | $798K | $798K | $3.3M |
| 43 | Florida Heart Research Foundation INC Miami | $777K | $777K | $358K |
| 44 | Girl Power 2 Cure INC Fernandina Beach | $773K | $709K | $289K |
| 45 | Clara a Schiller Pepetual Charitable Trust St. Petersburg | $769K | $0 | $2.1M |
| 46 | Ntm Info & Research INC Palmetto Bay | $759K | $759K | $147K |
| 47 | Albert Research Institute for White Matter and Cognition INC West Palm Beach | $757K | $757K | $809K |
| 48 | Bay Area Advisors INC Tampa | $727K | $357K | $81K |
| 49 | Sleep Consortium West Palm Bch | $665K | $665K | $391K |
| 50 | Red Sneakers for Oakley INC West Palm Beach | $627K | $521K | $514K |