| 1 | Sutter Bay Medical Foundation Sacramento | $4.1B | $4.1B | $2.5B |
| 2 | Beckman Research Institute Duarte | $1.2B | $285.3M | $2.2B |
| 3 | Scripps Research Institute La Jolla | $1.1B | $641.1M | $1.3B |
| 4 | Sanford Burnham Prebys Medical Discovery Institute La Jolla | $199.7M | $123.3M | $326.4M |
| 5 | J David Gladstone Institutes San Francisco | $146.3M | $119.2M | $372.0M |
| 6 | Arc Research Institute Palo Alto | $122.3M | $122.3M | $184.4M |
| 7 | Heritage Medical Research Institute Bakersfield | $119.2M | $19.0M | $253.3M |
| 8 | Lundquist Institute for Biomedical Innovation at Harbor-ucla Medical Torrance | $101.0M | $97.2M | $159.7M |
| 9 | Chan Zuckerberg Biohub INC San Francisco | $99.6M | $99.6M | $1.5B |
| 10 | Northern California Institute for Research and Education INC San Francisco | $62.4M | $62.3M | $21.3M |
| 11 | Global Coalition for Adaptive Research INC Larkspur | $46.1M | $27.7M | $63.6M |
| 12 | Gary and Mary West Health Institute La Jolla | $44.6M | $44.6M | $28.4M |
| 13 | Hopelab Foundation INC San Francisco | $39.2M | $0 | $27.3M |
| 14 | Rady Childrens Hospital Research Center San Diego | $38.9M | $24.4M | $35.2M |
| 15 | Palo Alto Veterans Institute for Research Palo Alto | $31.7M | $31.6M | $17.2M |
| 16 | Medicines360 San Francisco | $29.2M | $14.8M | $52.0M |
| 17 | Hoffman Institute Supportingfoundation San Rafael | $26.5M | $4.2M | $20.7M |
| 18 | Mann Medical Research Organization San Fernando | $26.1M | $0 | $50.5M |
| 19 | Huntington Medical Research Institutes Pasadena | $20.4M | $9.8M | $64.3M |
| 20 | Movember Foundation Santa Monica | $16.5M | $16.5M | $38.6M |
| 21 | Veterans Medical Research Foundation of Sd San Diego | $16.0M | $16.0M | $4.8M |
| 22 | Larry L Hillblom Foundation INC Sonoma | $15.8M | $0 | $152.5M |
| 23 | Translational Research in Oncology US INC Los Angeles | $15.7M | $0 | $25.8M |
| 24 | Agouron Institute Pasadena | $14.9M | $0 | $11.5M |
| 25 | Cedars Sinai Intellectual Property Company W Hollywood | $14.6M | $12.3M | $149.7M |
| 26 | Cure Duchenne Mission Viejo | $14.0M | $3.9M | $30.9M |
| 27 | Scleroderma Research Foundation San Francisco | $12.4M | $12.2M | $33.0M |
| 28 | Glaucoma Research Foundation San Francisco | $11.5M | $10.1M | $16.5M |
| 29 | Olive View UCLA Education and Research Institute INC Sylmar | $11.1M | $11.1M | $14.3M |
| 30 | Sanford Consortium for Regenerative Medicine La Jolla | $10.0M | $10.0M | $83.4M |
| 31 | World Molecular Imaging Society Culver City | $9.9M | $1.5M | $2.3M |
| 32 | Sansum Diabetes Research Institute Santa Barbara | $9.7M | $4.4M | $26.5M |
| 33 | Loma Linda University Pathology Medical Group INC Loma Linda | $9.2M | $6.2M | $7.5M |
| 34 | Arthritis National Research Foundation Irvine | $7.7M | $4.7M | $10.2M |
| 35 | International Anesthesia Research Society Walnut Creek | $7.7M | $6.9M | $35.3M |
| 36 | Multidisciplinary Association for Psychedelic Studies Santa Clara | $7.5M | $7.5M | $79.5M |
| 37 | Wings for Life USA - Spinal Cord Research Foundation INC Santa Monica | $6.6M | $6.6M | $16.1M |
| 38 | Center for Applied Rationality Berkeley | $6.3M | $6.3M | $23.0M |
| 39 | The Lowy Medical Research Institute INC La Jolla | $6.3M | $0 | $4.6M |
| 40 | Michael Toshio Cure for Cancer Foundation Burlingame | $6.2M | $0 | $14.1M |
| 41 | Lucky Duck Foundation San Diego | $6.0M | $5.8M | $11.6M |
| 42 | American Friends of Mutala INC El Granada | $5.6M | $5.6M | $5.2M |
| 43 | Dr Nasser Javahery Foundation W Hollywood | $5.3M | $2.1M | $1.8M |
| 44 | Global Gifted Foundation Orange | $4.7M | $4.7M | $8.9M |
| 45 | Applied Biomedical Science Institute San Diego | $4.7M | $4.5M | $2.6M |
| 46 | Sino-american Cancer Foundation Covina | $4.5M | $0 | $7.0M |
| 47 | Open Medicine Foundation INC Agoura Hills | $4.3M | $4.3M | $7.3M |
| 48 | That Man May See INC San Francisco | $4.2M | $4.2M | $11.3M |
| 49 | International Neuromodulation Society San Francisco | $4.1M | $2.1M | $1.8M |
| 50 | Alzheimers San Diego San Diego | $3.8M | $3.7M | $8.3M |