| 1 | The Evangelical Lutheran Good Samaritan Society Sioux Falls | $1.2B | $1.0B | $970.4M |
| 2 | Childrens Home Foundation Sioux Falls | $84.7M | $16.7M | $179.1M |
| 3 | Dow Rummel Village Sioux Falls | $48.3M | $26.2M | $71.7M |
| 4 | Childrens Home Society of South Dakota Sioux Falls | $46.5M | $36.1M | $58.9M |
| 5 | South Dakota Achieve Sioux Falls | $43.7M | $43.7M | $28.1M |
| 6 | Dakotabilities Sioux Falls | $24.5M | $23.7M | $24.0M |
| 7 | Lifequest Mitchell | $20.0M | $19.9M | $9.1M |
| 8 | Human Service Agency Watertown | $17.4M | $17.4M | $20.3M |
| 9 | Inter-lakes Community Action Partnership INC Madison | $17.2M | $17.0M | $14.8M |
| 10 | Native American Veterans Assistance Rapid City | $13.9M | $13.9M | $9.0M |
| 11 | Abbott House INC Mitchell | $13.1M | $13.1M | $13.6M |
| 12 | Jenkins Living Center INC Watertown | $10.6M | $10.6M | $15.6M |
| 13 | Boys and Girls Clubs of Sioux Empire Sioux Falls | $10.4M | $10.3M | $11.2M |
| 14 | Ability Building Services INC Yankton | $10.1M | $10.1M | $10.9M |
| 15 | Rapid City Y M C a Rapid City | $9.3M | $8.6M | $16.0M |
| 16 | United Retirement Center Brookings | $9.1M | $9.1M | $8.1M |
| 17 | Advance Brookings | $9.0M | $9.0M | $9.7M |
| 18 | Seed for Success Foundation Sioux Falls | $8.8M | $0 | $1.9M |
| 19 | Indian Board of Education for the Pierre Indian School Pierre | $7.0M | $7.0M | $20.0M |
| 20 | Ronald McDonald House Charities of South Dakota INC Sioux Falls | $6.8M | $6.6M | $12.1M |
| 21 | Bethel Lutheran Home Madison | $6.7M | $6.7M | $7.1M |
| 22 | Oahe Young Mens Christian Pierre | $5.7M | $3.3M | $14.3M |
| 23 | Young Mens Christian Association Sioux Falls | $5.4M | $5.3M | $7.8M |
| 24 | Dakota Milestones Chamberlain | $5.0M | $4.9M | $4.3M |
| 25 | Community Connections INC Winner | $4.9M | $4.9M | $4.9M |
| 26 | Brookings Area Transit Authority Brookings | $4.6M | $4.5M | $5.3M |
| 27 | Asone Ministries Sioux Falls | $4.4M | $4.4M | $2.2M |
| 28 | West River Transit Authority INC Spearfish | $4.3M | $4.3M | $10.6M |
| 29 | Wellspring INC Rapid City | $4.0M | $4.0M | $5.7M |
| 30 | Senior Citizens Services INC Sioux Falls | $3.9M | $3.9M | $18.6M |
| 31 | Sacred Heart Center Eagle Butte | $3.6M | $3.6M | $5.7M |
| 32 | Abbott House Foundation Mitchell | $3.4M | $2.4M | $8.6M |
| 33 | Compassion Child Care Sioux Falls | $3.4M | $3.0M | $2.1M |
| 34 | Diamond Willow Ministries Fort Thompson | $3.3M | $3.2M | $5.9M |
| 35 | Call to Freedom INC Sioux Falls | $3.2M | $3.2M | $3.9M |
| 36 | Furniture Mission Sioux Falls | $3.1M | $1.2M | $3.0M |
| 37 | Wakonda Heritage Manor Wakonda | $3.0M | $3.0M | $3.5M |
| 38 | Mitchell Area Safehouse INC Mitchell | $2.8M | $2.8M | $3.1M |
| 39 | Menno Olivet Care Center INC Menno | $2.8M | $2.8M | $2.0M |
| 40 | Giving Hope INC Sioux Falls | $2.6M | $921K | $248K |
| 41 | Area IV Senior Citizens Planning Council INC Aberdeen | $2.4M | $2.4M | $1.0M |
| 42 | Youth and Family Services Foundation Rapid City | $2.0M | $1.1M | $8.5M |
| 43 | Pfeiffer Family Foundation Aberdeen | $1.8M | $0 | $5.9M |
| 44 | Re-member Pine Ridge | $1.8M | $1.7M | $2.6M |
| 45 | Sioux YMCA Dupree | $1.7M | $1.5M | $4.1M |
| 46 | Rushmore Consumer Credit Resource Center Rapid City | $1.7M | $862K | $1.5M |
| 47 | Karl & Mary Jo Wegner Health Science Information Center Sioux Falls | $1.7M | $1.7M | $9.2M |
| 48 | Peoples Transit Huron | $1.7M | $1.7M | $2.2M |
| 49 | Missouri Shores Domestic Violence Center Pierre | $1.6M | $1.6M | $3.5M |
| 50 | Sioux Falls Ministry Center Sioux Falls | $1.6M | $1.6M | $9.2M |