| 1 | Avera McKennan Sioux Falls | $1.8B | $1.7B | $1.8B |
| 2 | Monument Health Rapid City Hospital INC Rapid City | $1.0B | $1.0B | $1.4B |
| 3 | Prairie Lakes Health Care System INC Watertown | $604.1M | $161.9M | $441.1M |
| 4 | Avera Health Plans INC Sioux Falls | $322.2M | $307.1M | $97.1M |
| 5 | Avera Health Sioux Falls | $278.9M | $278.4M | $2.3B |
| 6 | Monument Health Network INC Rapid City | $220.1M | $220.0M | $160.9M |
| 7 | Avera St. Lukes Aberdeen | $209.0M | $197.1M | $150.1M |
| 8 | Sacred Heart Health Services Yankton | $157.1M | $156.8M | $429.2M |
| 9 | Avera Queen of Peace Mitchell | $144.2M | $142.6M | $180.6M |
| 10 | Sanford Sioux Falls | $135.5M | $35.2M | $792.7M |
| 11 | Avera St. Marys Pierre | $124.2M | $122.1M | $98.1M |
| 12 | Avera at Home Sioux Falls | $83.2M | $83.2M | $41.5M |
| 13 | Lifescape Foundation Sioux Falls | $44.1M | $28.6M | $148.4M |
| 14 | Madison Community Hospital Madison | $37.3M | $37.3M | $59.3M |
| 15 | Horizon Health Care INC Howard | $34.3M | $34.3M | $25.7M |
| 16 | Fall River Health Services Hot Springs | $33.1M | $33.1M | $40.8M |
| 17 | St. Benedict Health Center Parkston | $32.8M | $32.8M | $91.1M |
| 18 | Hegg Memorial Hospital Sioux Falls | $30.7M | $30.7M | $58.7M |
| 19 | Platte Community Memorial Hospital INC Platte | $30.7M | $21.2M | $35.3M |
| 20 | Mobridge Regional Hospital Mobridge | $30.0M | $30.0M | $58.8M |
| 21 | Winner Regional Healthcare Center Winner | $27.9M | $27.9M | $27.6M |
| 22 | Coteau des Prairies Hospital Sisseton | $23.9M | $23.9M | $22.3M |
| 23 | Brookings Health System Investment Authority Brookings | $22.9M | $3.9M | $70.7M |
| 24 | Bethany Lutheran Home Sioux Falls | $22.0M | $19.9M | $31.4M |
| 25 | Freeman Regional Health Services Freeman | $19.5M | $19.4M | $25.7M |
| 26 | Philip Health Services INC Philip | $19.4M | $19.4M | $27.2M |
| 27 | Wagner Community Memorial Hospital Wagner | $18.6M | $18.1M | $20.1M |
| 28 | Marshall County Memorial Hospital Britton | $18.0M | $13.6M | $17.5M |
| 29 | F-m Ambulance Service INC Sioux Falls | $17.7M | $17.7M | $9.8M |
| 30 | Sanford Health Foundation North Sioux Falls | $16.7M | $10.9M | $107.3M |
| 31 | Pioneer Memorial Hospital & Health Services Viborg | $14.2M | $14.2M | $21.2M |
| 32 | Avera Gettysburg Gettysburg | $13.7M | $13.7M | $35.5M |
| 33 | Douglas County Memorial Hospital Armour | $12.7M | $12.7M | $19.3M |
| 34 | Bennett County Hospital and Nursing Home Martin | $12.6M | $12.6M | $9.2M |
| 35 | Faulkton Area Medical Center Faulkton | $12.0M | $12.0M | $13.1M |
| 36 | South Dakota Lions Eye and Tissue Bank INC Sioux Falls | $9.9M | $9.5M | $12.3M |
| 37 | Prairie Lakes Health Care Foundation Watertown | $8.1M | $817K | $5.4M |
| 38 | Sanford Health Foundation West Sioux Falls | $7.6M | $4.7M | $35.1M |
| 39 | Sunset Manor INC Irene | $7.2M | $7.2M | $5.0M |
| 40 | Landmann Jungman Memorial Hospital Corporation Scotland | $6.9M | $6.9M | $5.0M |
| 41 | Eureka Community & Benevolent Hospital Eureka | $5.8M | $5.8M | $10.7M |
| 42 | Lifescape Sioux Falls | $5.3M | $5.3M | $539K |
| 43 | Walworth County Care Center INC Selby | $4.5M | $4.5M | $4.0M |
| 44 | Delta Dental of South Dakota Foundation Pierre | $4.4M | $2.8M | $8.5M |
| 45 | Community Healthcare Association of the Dakotas Sioux Falls | $4.3M | $4.3M | $1.2M |
| 46 | South Dakota Foundation for Medical Care Sioux Falls | $3.8M | $3.8M | $2.0M |
| 47 | Weskota Manor INC Wessingtn Spg | $3.7M | $3.7M | $2.2M |
| 48 | Lemmon Area Medical Association Lemmon | $3.6M | $3.6M | $3.8M |
| 49 | Huron Clinic Foundation INC Huron | $3.6M | $3.6M | $3.7M |
| 50 | Tower Industry Family Support Charitable Foundation Watertown | $3.4M | $1.1M | $6.3M |