| 1 | Prisma Health - Upstate Greenville | $3.2B | $3.2B | $1.3B |
| 2 | Lexington Health INC West Columbia | $2.0B | $1.8B | $2.3B |
| 3 | Prisma Health-midlands Greenville | $1.8B | $1.8B | $909.4M |
| 4 | McLeod Regional Medical Center of the Pee Dee INC Florence | $1.7B | $1.3B | $2.7B |
| 5 | Prisma Health-university Medical Group Greenville | $893.6M | $893.4M | $149.6M |
| 6 | Anmed Health Anderson | $860.0M | $854.6M | $1.5B |
| 7 | Bon Secours-st Francis Xavier Hospital INC Charleston | $621.0M | $620.6M | $319.0M |
| 8 | Roper Hospital INC Charleston | $539.5M | $539.5M | $343.1M |
| 9 | McLeod Loris Seacoast Hospital Loris | $425.9M | $422.9M | $425.9M |
| 10 | Conway Hospital INC Conway | $358.5M | $358.2M | $798.3M |
| 11 | McLeod Health Florence | $340.8M | $340.8M | $235.1M |
| 12 | Georgetown Memorial Hospital Georgetown | $267.2M | $267.1M | $65.8M |
| 13 | McLeod Physician Associates II Florence | $258.0M | $258.0M | $73.9M |
| 14 | Waccamaw Community Hospital Georgetown | $225.6M | $225.6M | $273.9M |
| 15 | Prisma Health Tuomey Greenville | $215.3M | $215.3M | $158.4M |
| 16 | Roper Saint Francis Physicians Network Ladson | $213.1M | $213.0M | $94.4M |
| 17 | Georgetown Hospital System Georgetown | $209.6M | $209.5M | $614.4M |
| 18 | Hopehealth INC Florence | $200.7M | $200.5M | $141.3M |
| 19 | Greenville Health Corporation Greenville | $196.3M | $196.3M | $59.2M |
| 20 | Bon Secours Medical Group Greenville Specialty Care LLC Greenville | $155.6M | $155.6M | $24.4M |
| 21 | Roper St. Francis Hospital-berkeley INC Summerville | $152.1M | $152.1M | $281.9M |
| 22 | The Blood Connection Incorporated Piedmont | $146.7M | $144.4M | $101.9M |
| 23 | Roper St. Francis Mount Pleasant Hospital Mt Pleasant | $139.7M | $139.7M | $86.6M |
| 24 | Prisma Health Greenville | $136.6M | $136.6M | $3.8B |
| 25 | Mainsail Health Partners Charleston | $125.7M | $125.7M | $345.8M |
| 26 | Caresouth Carolina INC Hartsville | $107.8M | $73.2M | $44.8M |
| 27 | McLeod Medical Center Foundation Florence | $104.4M | $16.7M | $32.3M |
| 28 | Welvista Columbia | $96.1M | $96.0M | $48.7M |
| 29 | McLeod Health Clarendon Manning | $92.5M | $91.6M | $40.8M |
| 30 | McLeod Medical Center Dillon Dillon | $80.2M | $79.8M | $135.9M |
| 31 | McLeod Health Cheraw Cheraw | $79.2M | $78.8M | $29.7M |
| 32 | Genesis Healthcare INC Columbia | $65.9M | $65.9M | $146.1M |
| 33 | Beaufort Memorial Hospital Endowment Foundation Beaufort | $59.0M | $6.4M | $26.1M |
| 34 | Carolina Health Centers INC Greenwood | $57.1M | $40.1M | $26.5M |
| 35 | South Carolina Episcopal Home at Still Hopes West Columbia | $54.8M | $45.8M | $195.7M |
| 36 | Little River Medical Center INC Little River | $50.6M | $49.7M | $34.4M |
| 37 | Hampton Regional Medical Center Varnville | $46.0M | $36.9M | $63.3M |
| 38 | St. Francis Physician Services INC Greenville | $36.9M | $36.9M | $123.7M |
| 39 | The Charles Lea Center INC Spartanburg | $36.7M | $36.6M | $14.9M |
| 40 | Lexmed INC Lexington | $36.2M | $36.2M | $23.8M |
| 41 | Anmed Health Cannon Pickens | $36.1M | $36.0M | $27.3M |
| 42 | Sandhills Medical Foundation INC Jefferson | $35.1M | $35.1M | $27.5M |
| 43 | Tandem Health Sc Sumter | $33.3M | $33.2M | $22.3M |
| 44 | Regenesis Organization Community Health Center Spartanburg | $32.3M | $31.2M | $16.0M |
| 45 | Low Country Health Care System Fairfax | $32.3M | $32.3M | $22.7M |
| 46 | New Horizon Family Health Services INC Greenville | $31.3M | $31.3M | $23.3M |
| 47 | Beaufort-jasper-hampton Comprehensive Health Services INC Ridgeland | $30.7M | $30.7M | $26.8M |
| 48 | Musc Health Partners Charleston | $29.8M | $29.8M | $3.5M |
| 49 | The Spartanburg Regional Healthcare System Foundation Spartanburg | $26.7M | $13.1M | $67.4M |
| 50 | Self Regional Healthcare Partners Greenwood | $22.9M | $22.9M | $5.9M |