| 1 | Astrazeneca Patient Assistance Organization Wilmington | $4.6B | $4.6B | $0 |
| 2 | Christiana Care Health Services INC Wilmington | $3.9B | $3.1B | $4.8B |
| 3 | Bayhealth Medical Center INC Dover | $1.3B | $1.1B | $1.8B |
| 4 | Beebe Medical Center INC Lewes | $644.7M | $634.9M | $723.8M |
| 5 | Union Hospital of Cecil County Wilmington | $210.2M | $194.5M | $209.2M |
| 6 | Tidalhealth Nanticoke INC Seaford | $201.4M | $173.3M | $163.5M |
| 7 | St. Francis Hospital INC Wilmington | $161.8M | $161.5M | $75.6M |
| 8 | Five Pointe Professional Liability Insurance Company Wilmington | $153.4M | $74.4M | $437.3M |
| 9 | Beebe Physican Network INC Lewes | $62.2M | $62.2M | $23.9M |
| 10 | Christiana Care Home Health and Community Services INC Wilmington | $45.3M | $39.9M | $23.9M |
| 11 | Easter Seals Delaware & Marylands Eastern Shore INC New Castle | $37.5M | $37.2M | $64.7M |
| 12 | Exceptional Care for Children INC Newark | $23.2M | $19.8M | $47.6M |
| 13 | Milton and Hattie Kutz Home INC Wilmington | $21.4M | $17.6M | $20.7M |
| 14 | Nemours New Jersey Physician Practice Pc Wilmington | $18.6M | $18.5M | $2.8M |
| 15 | Beebe Medical Foundation Lewes | $13.2M | $12.6M | $41.6M |
| 16 | La Red Health Center INC Georgetown | $12.8M | $12.8M | $11.9M |
| 17 | Andrew McDonough B Positive Foundation Wilmington | $11.5M | $10.9M | $7.7M |
| 18 | Aids Delaware INC Wilmington | $10.7M | $10.7M | $2.3M |
| 19 | Newark Emergency Center INC Newark | $10.5M | $8.8M | $4.9M |
| 20 | Affinity Health Alliance INC Wilmington | $10.1M | $2.4M | $77.3M |
| 21 | Planned Parenthood Direct INC Wilmington | $9.1M | $9.1M | $3.1M |
| 22 | Kendal Corporation Newark | $9.1M | $7.8M | $19.0M |
| 23 | Barr-campbell Family Foundation INC Wilmington | $8.6M | $0 | $13.7M |
| 24 | Planned Parenthood of Delaware INC Wilmington | $7.2M | $7.2M | $5.8M |
| 25 | Aetna Hose Hook and Ladder Company of Newark Delaware Newark | $6.9M | $6.9M | $7.4M |
| 26 | The Life Center Complex INC Wilmington | $5.3M | $5.3M | $9.6M |
| 27 | Christiana Care Health Initiatives INC Wilmington | $5.2M | $4.8M | $7.4M |
| 28 | Village of Hope America INC Dover | $4.0M | $4.0M | $1.5M |
| 29 | Union Hospital of Cecil County Health Services INC Willmington | $3.4M | $3.4M | $18.5M |
| 30 | Delaware Breast Cancer Coalition Wilmington | $3.0M | $2.6M | $3.5M |
| 31 | American Philosophical Association INC Newark | $2.8M | $1.8M | $8.7M |
| 32 | American Legion Ambulance Station 64 INC Smyrna | $2.4M | $2.4M | $3.7M |
| 33 | Marino Health Foundation INC Wilmington | $2.1M | $0 | $5.4M |
| 34 | International Medical Aid Foundation Dover | $1.9M | $0 | $1K |
| 35 | Delaware School Based Health Alliance INC Newark | $1.7M | $1.7M | $982K |
| 36 | The Rosa Health Center INC Lewes | $1.6M | $1.6M | $1.4M |
| 37 | Cancer Support Community Delaware INC Wilmington | $1.5M | $921K | $2.9M |
| 38 | Livjoy Foundation INC Wilmington | $1.3M | $0 | $877K |
| 39 | Christiana Care Gene Editing Wilmington | $1.2M | $1.2M | $2.6M |
| 40 | Gastro Girl Patient Institute Dover | $1.1M | $1.1M | $755K |
| 41 | Delaware Medical Education Foundation Ltd Middletown | $1.0M | $1.0M | $436K |
| 42 | Delaware Health Sciences Alliance LLC Newark | $959K | $959K | $4.7M |
| 43 | Delaware Health Net INC Georgetown | $892K | $892K | $412K |
| 44 | Down Syndrome Association of Delaware Middletown | $779K | $720K | $877K |
| 45 | A Door of Hope Pregnancy Center INC Wilmington | $769K | $728K | $1.0M |
| 46 | The Childrens Dispensary & Hospital Association of South Bend Indiana Wilmington | $695K | $233K | $3.3M |
| 47 | Bayhealth Foundation Dover | $658K | $626K | $14.2M |
| 48 | Delaware Foundation for Medical Services Ltd Middletown | $547K | $131K | $1.8M |
| 49 | Do Care Doula Foundation INC Dover | $469K | $469K | $237K |
| 50 | End Drug Shortages Alliance Association Wilmington | $431K | $431K | $769K |