| 1 | Trustees of the University of Pennsylvania Philadelphia | $20.4B | $10.7B | $34.0B |
| 2 | Milton Hershey School & School Trust Hershey | $5.8B | $814.0M | $23.4B |
| 3 | University of Pittsburgh Pittsburgh | $5.3B | $3.4B | $10.5B |
| 4 | Temple University-of the Commonwealth System of Higher Educ Philadelphia | $2.2B | $1.6B | $4.1B |
| 5 | Thomas Jefferson University Philadelphia | $1.6B | $1.6B | $5.1B |
| 6 | Drexel University Philadelphia | $1.5B | $1.4B | $2.9B |
| 7 | Swarthmore College Swarthmore | $1.2B | $361.6M | $3.6B |
| 8 | Bucknell University Lewisburg | $1.1B | $423.6M | $1.7B |
| 9 | Lehigh University Bethlehem | $1.0B | $748.5M | $3.3B |
| 10 | Lafayette College Easton | $620.1M | $262.5M | $1.7B |
| 11 | Duquesne University of the Holy Spirit Pittsburgh | $537.2M | $472.6M | $1.2B |
| 12 | Commonwealth Charter Academy Charter School Harrisburg | $531.8M | $531.8M | $856.4M |
| 13 | Saint Josephs University Philadelphia | $531.5M | $424.6M | $1.6B |
| 14 | Jefferson University Physicians Philadelphia | $506.4M | $505.7M | $192.2M |
| 15 | Bryn Mawr College Bryn Mawr | $443.3M | $254.6M | $1.6B |
| 16 | Franklin & Marshall College Lancaster | $435.6M | $201.4M | $855.8M |
| 17 | Widener University Chester | $402.2M | $267.4M | $406.2M |
| 18 | University of Scranton Scranton | $382.6M | $278.9M | $647.7M |
| 19 | Dickinson College Carlisle | $364.5M | $244.5M | $914.0M |
| 20 | Regents of the Mercersburg College Mercersburg | $320.9M | $70.6M | $605.2M |
| 21 | Pennsylvania Cyber Charter School Midland | $294.1M | $223.6M | $461.2M |
| 22 | Philadelphia College of Osteopathic Medicine Foundation Philadelphia | $284.6M | $22.6M | $611.3M |
| 23 | Temple University Health System INC Philadelphia | $283.6M | $283.2M | $675.3M |
| 24 | Messiah University Mechanicsburg | $273.5M | $149.7M | $322.3M |
| 25 | York College of Pennsylvania York | $269.7M | $149.9M | $577.8M |
| 26 | Business Leadership Organized for Catholic Schools Kng of Prussa | $262.2M | $108.5M | $137.3M |
| 27 | Community Services for Children INC Allentown | $256.0M | $255.5M | $59.2M |
| 28 | Gettysburg College Gettysburg | $252.9M | $228.8M | $661.3M |
| 29 | Hawthornden Foundation Pittsburgh | $242.2M | $0 | $225.5M |
| 30 | Ursinus College Collegeville | $230.6M | $127.9M | $326.5M |
| 31 | Lake Erie College of Osteopathic Medicine INC Erie | $222.1M | $222.1M | $1.1B |
| 32 | Academy of the New Church Bryn Athyn | $218.1M | $49.3M | $419.1M |
| 33 | Corporation of Haverford College Haverford | $211.6M | $205.0M | $962.8M |
| 34 | Allegheny College Meadville | $208.0M | $141.2M | $440.0M |
| 35 | Muhlenberg College Allentown | $203.3M | $149.6M | $592.2M |
| 36 | Arcadia University Glenside | $186.0M | $164.4M | $242.6M |
| 37 | Philadelphia College of Osteopathic Medicine Philadelphia | $184.0M | $183.5M | $151.2M |
| 38 | Wilkes University Wilkes Barre | $175.1M | $151.9M | $251.0M |
| 39 | Gannon University Erie | $174.8M | $165.8M | $324.8M |
| 40 | Susquehanna University Selinsgrove | $174.3M | $174.3M | $376.3M |
| 41 | Desales University Center Valley | $174.3M | $142.5M | $252.5M |
| 42 | Philadelphia University Philadelphia | $173.3M | $173.3M | $209.4M |
| 43 | Mercyhurst University Erie | $164.8M | $146.9M | $161.6M |
| 44 | Lebanon Valley College Annville | $160.0M | $120.6M | $268.8M |
| 45 | Washington and Jefferson College Washington | $158.0M | $112.3M | $358.9M |
| 46 | Grove City College Grove City | $157.2M | $124.5M | $547.1M |
| 47 | La Salle University Philadelphia | $154.4M | $118.8M | $243.8M |
| 48 | Holy Family University Philadelphia | $148.7M | $96.4M | $134.9M |
| 49 | Intealth Philadelphia | $135.6M | $93.6M | $221.5M |
| 50 | Reach Cyber Charter School Harrisburg | $132.4M | $132.4M | $95.7M |