| 1 | Affinity Health Center Rock Hill | $27.7M | $27.7M | $26.2M |
| 2 | Guardian Research Network INC Spartanburg | $7.7M | $0 | $2.8M |
| 3 | Cces Endowment Corporation Greenville | $2.4M | $742K | $8.8M |
| 4 | Cancer Association of Anderson Anderson | $2.0M | $1.9M | $2.3M |
| 5 | Head & Neck Cancer Alliance INC Charleston | $1.8M | $1.7M | $2.2M |
| 6 | National Federation of the Blind of South Carolina Columbia | $1.8M | $1.8M | $1.9M |
| 7 | South Carolina Autism Society INC West Columbia | $1.6M | $1.6M | $510K |
| 8 | James R Clark Memorial Sickle Cell Foundation INC Columbia | $1.4M | $1.3M | $586K |
| 9 | Lions Vision Services a South Carolina Charity Columbia | $1.4M | $1.4M | $2.8M |
| 10 | Chrysalis Autism Center INC Rock Hill | $1.1M | $1.1M | $430K |
| 11 | Beautiful Gate Center N Charleston | $1.1M | $1.1M | $329K |
| 12 | Abvi Foundation Charleston | $1.0M | $494K | $5.8M |
| 13 | Advanced Institute for Development and Learning Greenville | $881K | $858K | $88K |
| 14 | Ark of Sc Summerville | $739K | $739K | $650K |
| 15 | Pledge the Pink Foundation Bluffton | $693K | $693K | $119K |
| 16 | Rock the Block Charleston | $664K | $159K | $142K |
| 17 | North Charleston Dental Outreach Charleston | $607K | $607K | $1.3M |
| 18 | Lowcountry Autism Foundation INC Bluffton | $448K | $357K | $91K |
| 19 | Neuroendocrine Cancer Awareness Network INC Fort Mill | $405K | $405K | $109K |
| 20 | Beginnings for Parents of Children Who Are Deaf or Hard of Hearing-sc West Columbia | $383K | $383K | $121K |
| 21 | Nothing Pink INC Fort Mill | $376K | $291K | $186K |
| 22 | Servants for Sight Greenville | $353K | $353K | $794K |
| 23 | Louvenia D Barksdale Sickle Cell Anemia Foundation INC Spartanburg | $299K | $299K | $77K |
| 24 | Dragon Boat Charleston Charleston | $238K | $235K | $270K |
| 25 | Happy Wheels INC Lexington | $234K | $234K | $345K |
| 26 | Cancer of Many Colors INC Lexington | $232K | $208K | $305K |
| 27 | South Carolina Ovarian Cancer Foundation Greenville | $227K | $92K | $460K |
| 28 | Carolina Childrens Charity INC Charleston | $225K | $190K | $779K |
| 29 | Mod Dental Aesthetics Charleston | $214K | $214K | $289K |
| 30 | Committee on Better Racial Assurance N Charleston | $198K | $198K | $357K |
| 31 | Calhoun Traumatic Brain Injury Foundation Columbia | $191K | $155K | $149K |
| 32 | Fighting to Win INC Beech Island | $183K | $168K | $443K |
| 33 | Battle Buddies Piedmont | $180K | $180K | $16K |
| 34 | National Federation of the Blind of South Carolina Columbia | $170K | $170K | $81K |
| 35 | National Federation of the Blind of South Carolina Columbia | $170K | $170K | $81K |
| 36 | Champion Autism Network Surfside Bch | $157K | $157K | $15K |
| 37 | Trailhead Community Farm School Greenville | $148K | $148K | $18K |
| 38 | Friends of the York County Library Rock Hill | $138K | $138K | $167K |
| 39 | Annual Sc Hiv-std Conference Columbia | $138K | $138K | $215K |
| 40 | Rms Family Foundation INC Myrtle Beach | $137K | $0 | $14K |
| 41 | All 4 Autism Florence | $127K | $110K | $68K |
| 42 | Operation Sight Mt Pleasant | $124K | $124K | $60K |
| 43 | South Carolina Society for Respiratory Care West Columbia | $109K | $109K | $127K |
| 44 | Orangeburg Area Sickle Cell Anemia Foundation Orangeburg | $108K | $108K | $58K |
| 45 | A Steady Hand Foundation INC Summerville | $101K | $101K | $50K |
| 46 | South Carolina Rheumatism Society Summerville | $101K | $101K | $167K |
| 47 | Hope Helping Others Progress Through Education Rock Hill | $100K | $100K | $0 |
| 48 | South Carolina Neurological Assn. Columbia | $94K | $94K | $152K |
| 49 | Walk for Autism - Charleston N Charleston | $91K | $91K | $100K |
| 50 | Partnership for Proactive Health INC Kiawah Island | $90K | $90K | $381K |