| 1 | World Federation of Hemophilia USA Albany | $1.1B | $1.1B | $377.6M |
| 2 | Blood Cancer United INC Rye Brook | $569.3M | $368.2M | $602.0M |
| 3 | Breakthrough T1d New York | $507.8M | $258.1M | $488.1M |
| 4 | Positudes INC Westbury | $324.5M | $7.0M | $39.5M |
| 5 | United Cerebral Palsy Associations of New York State INC New York | $243.5M | $243.5M | $206.9M |
| 6 | United Cerebral Palsy of New York City INC New York | $230.4M | $229.8M | $382.9M |
| 7 | National Multiple Sclerosis Society New York | $213.1M | $171.8M | $201.1M |
| 8 | The Center for Discovery INC Harris | $171.5M | $171.0M | $177.2M |
| 9 | Lymphoma Research Foundation New York | $130.4M | $13.9M | $42.8M |
| 10 | Upstate Cerebral Palsy INC Utica | $127.1M | $124.6M | $75.8M |
| 11 | Center for Disability Services INC Albany | $125.8M | $125.8M | $96.1M |
| 12 | Ehs INC Buffalo | $124.7M | $119.9M | $72.7M |
| 13 | Central Association for the Blind INC Utica | $123.1M | $30.0M | $128.1M |
| 14 | Crohns & Colitis Foundation INC New York | $105.3M | $85.2M | $50.6M |
| 15 | Qsac INC New York | $104.0M | $103.6M | $87.6M |
| 16 | Fund for Public Health in New York INC New York | $97.6M | $96.4M | $77.8M |
| 17 | Elton John Aids Foundation INC New York | $84.2M | $20.3M | $37.4M |
| 18 | Accesscny INC Syracuse | $60.1M | $57.2M | $33.6M |
| 19 | United Cerebral Palsy Association of Greater Suffolk INC Hauppauge | $56.6M | $56.5M | $43.1M |
| 20 | National Kidney Foundation INC New York | $56.3M | $50.1M | $51.5M |
| 21 | Daftuar Family Foundation New York | $49.3M | $0 | $104.8M |
| 22 | The Mark Foundation for Cancer Research US Ltd New York | $48.5M | $44.8M | $105.5M |
| 23 | Apicha Community Health Center New York | $46.9M | $41.1M | $50.8M |
| 24 | United Cerebral Palsy Association of Nassau County INC Roosevelt | $46.6M | $46.1M | $30.0M |
| 25 | Head Injury Association INC Hauppauge | $45.9M | $41.9M | $54.3M |
| 26 | Gay Mens Health Crisis INC New York | $39.6M | $38.7M | $113.6M |
| 27 | Epic Long Island INC East Meadow | $39.0M | $38.8M | $21.2M |
| 28 | United Cerebral Palsy of Queens Jamaica | $38.9M | $38.5M | $23.1M |
| 29 | Aids Service Center of Lower Manhattan INC New York | $38.1M | $38.1M | $33.1M |
| 30 | Housing Works Health Services III INC Brooklyn | $35.6M | $31.4M | $72.8M |
| 31 | American Parkinson Disease Assoc Staten Island | $35.2M | $23.4M | $30.3M |
| 32 | Cancer Care INC New York | $35.0M | $16.1M | $23.0M |
| 33 | Harlem United Community Aids Center INC New York | $34.2M | $34.2M | $54.6M |
| 34 | Felicity House INC New York | $33.1M | $0 | $94.6M |
| 35 | New York City Foundation for Cerebral Palsy INC New York | $31.3M | $19.8M | $166.4M |
| 36 | Frontier Science and Technology Research Foundation INC Amherst | $31.0M | $31.0M | $18.0M |
| 37 | Cerebral Palsy of Westchester INC Rye Brook | $27.5M | $27.4M | $34.6M |
| 38 | United Cerebral Palsy Association of the North Country INC Canton | $22.9M | $22.8M | $21.2M |
| 39 | Aids Center of Queens County INC Richmond Hill | $22.5M | $22.4M | $8.7M |
| 40 | Upper Room Aids Ministry INC Adult Day Health Care Center New York | $21.6M | $21.6M | $16.9M |
| 41 | Hki Support INC New York | $20.5M | $20.5M | $0 |
| 42 | Alzheimers Foundation of America INC New York | $20.3M | $20.0M | $75.9M |
| 43 | Bailey House INC Brooklyn | $20.1M | $19.9M | $33.7M |
| 44 | Wraparound Services of the Hudson Valley INC Lake Katrine | $19.7M | $18.0M | $14.1M |
| 45 | United Cerebral Palsy Association of the Rochester Area INC Rochester | $18.6M | $17.6M | $16.2M |
| 46 | United Cerebral Palsy Association of Niagara County INC Niagara Falls | $17.5M | $17.4M | $9.1M |
| 47 | Nassau Suffolk Services for the Autistic Commack | $17.0M | $13.7M | $13.7M |
| 48 | Alzheimers Disease and Related Disorders New York City INC New York | $16.7M | $9.6M | $10.5M |
| 49 | Kelberman Center INC Utica | $16.4M | $16.3M | $5.9M |
| 50 | Finger Lakes United Cerebral Palsy INC Geneva | $15.0M | $15.0M | $12.1M |