| 1 | Stowers Resource Management INC Kansas City | $259.9M | $157.1M | $2.0B |
| 2 | The Against Malaria Foundation Kansas City | $119.4M | $119.4M | $288K |
| 3 | United Cerebral Palsy Heartland Berkeley | $28.7M | $19.8M | $29.6M |
| 4 | Parents as Teachers National Center INC Saint Louis | $24.9M | $20.5M | $33.0M |
| 5 | Aids Project of the Ozarks Springfield | $24.9M | $23.9M | $14.3M |
| 6 | St. Vincent Seton Specialty Hospital INC Saint Louis | $21.4M | $21.4M | $13.4M |
| 7 | Interfaith Residence Saint Louis | $17.7M | $16.1M | $22.7M |
| 8 | Carondelet Long Term Care Facilities INC Saint Louis | $16.1M | $7.9M | $6.9M |
| 9 | Judevine INC Saint Louis | $15.0M | $15.0M | $10.0M |
| 10 | Missouri Lions Eye Research Foundation Kansas City | $11.4M | $11.0M | $14.4M |
| 11 | Bert Broday Jr Trust Fbo the American Heart Association Saint Louis | $5.5M | $0 | $12.5M |
| 12 | St. Francois Co Board for the Developmentally Disabled Farmington | $5.3M | $5.3M | $6.9M |
| 13 | United Cerebral Palsy of Northwest Missouri Saint Joseph | $4.6M | $4.6M | $8.7M |
| 14 | St. Louis Chapter Saint Louis | $3.5M | $3.4M | $1.5M |
| 15 | Fight Colorectal Cancer INC Springfield | $3.4M | $3.4M | $4.0M |
| 16 | Thompson Foundation for Autism & Neurodevelopment Columbia | $2.9M | $1.5M | $443K |
| 17 | Gateway to Hope Maplewood | $2.8M | $2.7M | $7.5M |
| 18 | Erise Williams and Associates INC St. Louis | $2.4M | $2.4M | $2.1M |
| 19 | Delta Gamma Center for Children with Visual Impairments Saint Louis | $2.3M | $2.2M | $8.1M |
| 20 | American Board of Nuclear Medicine INC Saint Louis | $2.2M | $1.1M | $4.9M |
| 21 | Ollie Hinkle Heart Foundation Saint Louis | $2.0M | $1.6M | $1.7M |
| 22 | Memory Care Home Solutions Saint Louis | $1.9M | $1.4M | $2.4M |
| 23 | National Association of Medical Examiners INC Savannah | $1.9M | $1.9M | $3.8M |
| 24 | Spastic Paraplegia Foundation INC O Fallon | $1.7M | $1.7M | $3.1M |
| 25 | St. Louis Society for the Blind and Visually Impaired Saint Louis | $1.7M | $71K | $18.3M |
| 26 | Achievements Unlimited INC Bridgeton | $1.6M | $1.6M | $1.3M |
| 27 | American Osteopathic College of Dermatology Kirksville | $1.5M | $1.2M | $1.6M |
| 28 | Mission Clinical Services Chesterfield | $1.2M | $1.1M | $1.6M |
| 29 | Manning Foundation Tr Saint Louis | $1.1M | $0 | $3.3M |
| 30 | Mighty Oakes Heart Foundation Saint Louis | $1.1M | $930K | $665K |
| 31 | Disability Resource in Homeservices INC Festus | $1.1M | $1.1M | $380K |
| 32 | Stowers Policy Institute INC Kansas City | $1.1M | $649K | $29.1M |
| 33 | Worldwide Fistula Fund INC Saint Louis | $818K | $818K | $2.4M |
| 34 | St. Louis Ovarian Cancer Awareness Saint Louis | $720K | $529K | $1.1M |
| 35 | Post-polio Health International INC Saint Louis | $664K | $195K | $910K |
| 36 | Fabry Support & Information Group Concordia | $646K | $645K | $759K |
| 37 | Down Country Taylor | $603K | $365K | $8K |
| 38 | Gildas Club Kansas City Kansas City | $561K | $521K | $290K |
| 39 | Tailor Institute Incorporated Cpe Girardeau | $468K | $468K | $191K |
| 40 | Edith S & James R Joyce Foundation Saint Louis | $458K | $0 | $1.2M |
| 41 | Habib Alrahman Charity Foundation Saint Louis | $424K | $424K | $302K |
| 42 | Pks Prayers Foristell | $402K | $402K | $332K |
| 43 | Ben Kruse 18 Fore Life Foundation Dexter | $398K | $398K | $16K |
| 44 | Creative Arts Therapy Center INC Monett | $364K | $364K | $71K |
| 45 | Super Sam Foundation Fulton | $358K | $305K | $181K |
| 46 | Sickle Cell Association Florissant | $323K | $323K | $57K |
| 47 | Down Syndrome Group of the Ozarks Springfield | $318K | $309K | $165K |
| 48 | Hope Happens INC Saint Louis | $306K | $268K | $214K |
| 49 | United Workers for the Blind of Missouri Saint Louis | $304K | $25K | $1.2M |
| 50 | Friends of the St. Louis University Liver Center St. Louis | $300K | $265K | $228K |