| 1 | Barbara Ann Karmanos Cancer Hospital Detroit | $574.7M | $572.6M | $237.1M |
| 2 | Michigan Health Endowment Fund Brighton | $322.4M | $116.1M | $589.1M |
| 3 | The Hope Foundation Ann Arbor | $53.3M | $28.6M | $62.6M |
| 4 | Munson Medical Group Traverse City | $31.6M | $31.6M | $9.8M |
| 5 | Detroit & Wayne County Tuberculosis Foundation St. Clr Shores | $26.5M | $9.0M | $32.1M |
| 6 | West Michigan Cancer Center Kalamazoo | $23.8M | $23.7M | $38.2M |
| 7 | National Kidney Foundation INC Ann Arbor | $14.8M | $14.4M | $16.7M |
| 8 | Health Emergency Assistance of Detroit Detroit | $13.9M | $13.9M | $8.2M |
| 9 | Nfx Detroit | $9.4M | $6.9M | $10.3M |
| 10 | Kirk H and Joann P Gibson Family Foundation for Parkinsons Research Farmington Hills | $9.4M | $7.7M | $17.2M |
| 11 | Guest House INC Lake Orion | $6.7M | $6.3M | $50.8M |
| 12 | Autism Alliance of Michigan Southfield | $5.4M | $5.0M | $2.8M |
| 13 | Hemophilia Foundation of Michigan Ypsilanti | $4.8M | $4.8M | $4.4M |
| 14 | Epilepsy Foundation of Michigan Southfield | $3.7M | $1.2M | $2.6M |
| 15 | Penrickton Center for Blind Children Taylor | $3.3M | $3.2M | $15.2M |
| 16 | Wellness Networks INC Detroit | $3.0M | $3.0M | $1.9M |
| 17 | Pink Fund INC Bingham Farms | $2.8M | $2.4M | $1.7M |
| 18 | Field Neuroscience Institute Midland | $2.7M | $1.1M | $13.9M |
| 19 | New Day Foundation for Families Rochester | $2.5M | $2.3M | $1.3M |
| 20 | American Autoimmune Related Diseases Association Clinton Twp | $2.4M | $2.4M | $2.9M |
| 21 | Team Lafontaine Ucancervive Foundation Bloomfld Hls | $2.3M | $2.0M | $1.6M |
| 22 | Sickle Cell Disease Association of America Michigan Chapter INC Detroit | $2.2M | $2.2M | $1.5M |
| 23 | Michigan Parkinson Foundation Bingham Farms | $2.2M | $2.0M | $5.2M |
| 24 | Caribbean Christian Centre for the Deaf INC Zeeland | $1.9M | $1.9M | $519K |
| 25 | Poetice Holland | $1.8M | $1.8M | $447K |
| 26 | Wellness Aids Services INC Burton | $1.7M | $1.7M | $1.0M |
| 27 | Childrens Leukemia Foundation of Michigan Farmingtn Hls | $1.6M | $1.5M | $4.6M |
| 28 | National Arab American Medical Association INC Troy | $1.6M | $1.6M | $2.7M |
| 29 | American Board of Colon and Rectal Taylor | $1.4M | $1.4M | $4.6M |
| 30 | Michigan United Cerebral Palsy Southfield | $1.3M | $1.0M | $845K |
| 31 | Learning Differences Resource Group Grand Rapids | $1.2M | $1.0M | $2.3M |
| 32 | Mad-id Incorporated Troy | $1.1M | $782K | $1.2M |
| 33 | Communication Access Center for the Deaf and Hard of Hearing INC Flushing | $936K | $936K | $55K |
| 34 | Michigan Dyslexia Institute INC Lansing | $935K | $910K | $1.4M |
| 35 | Brain Injury Association of Michigan Incorporated Brighton | $920K | $695K | $507K |
| 36 | Association for the Blind and Visually Impaired Grand Rapids | $918K | $918K | $1.2M |
| 37 | Dynami Foundation Birmingham | $880K | $444K | $927K |
| 38 | Specialized Language Development Center Kalamazoo | $845K | $845K | $303K |
| 39 | Cutaneous Lymphoma Foundation INC Warren | $837K | $837K | $937K |
| 40 | Amyotrophic Lateral Sclerosis Association of Michigan INC Southfield | $755K | $712K | $1.2M |
| 41 | Asppire Lansing | $664K | $664K | $432K |
| 42 | Shades of Pink Foundation Birmingham | $595K | $540K | $254K |
| 43 | Great Lakes Recovery Center Foundation Negaunee | $553K | $553K | $1.9M |
| 44 | Fasd Collaborative Project Saline | $550K | $550K | $20K |
| 45 | Hfm Camping Adventures Ypsilanti | $546K | $546K | $5K |
| 46 | Association of Interventional Pulmonary Program Directors Birmingham | $524K | $524K | $459K |
| 47 | National Council of Dementia Minds Owosso | $487K | $479K | $342K |
| 48 | Cayman Biomedical Research Institute Ann Arbor | $472K | $0 | $538K |
| 49 | American College of Neuropsychiatrists Farmington Hills | $442K | $373K | $1.1M |
| 50 | Huntingtons Disease Youth Organization of America Livonia | $416K | $416K | $452K |