| 1 | Cystic Fibrosis Foundation Bethesda | $1.9B | $355.8M | $5.0B |
| 2 | Chase Brexton Health Services INC Baltimore | $172.9M | $172.8M | $152.5M |
| 3 | Brightfocus Foundation Clarksburg | $89.2M | $63.4M | $65.1M |
| 4 | American Gastroenterological Association Institute INC Bethesda | $70.6M | $32.3M | $112.3M |
| 5 | Community Services for Autistic Adults and Children Montgomry Vlg | $65.3M | $65.2M | $55.8M |
| 6 | Hjf Medical Research International INC Bethesda | $57.0M | $57.0M | $15.3M |
| 7 | American Association of Immunologists INC Rockville | $37.8M | $15.0M | $85.6M |
| 8 | University of Maryland Pediatric as Sociates P a Baltimore | $36.7M | $36.7M | $33.7M |
| 9 | Easter Seals Serving Dc-md-va INC Silver Spring | $31.8M | $28.0M | $47.3M |
| 10 | Unified Community Connections INC Sparks | $30.1M | $29.9M | $34.0M |
| 11 | National Federation of the Blind INC Baltimore | $28.1M | $21.5M | $35.7M |
| 12 | Epilepsy Foundation of America Bowie | $21.6M | $15.6M | $21.3M |
| 13 | Identity INC Gaithersburg | $20.5M | $20.5M | $18.3M |
| 14 | Keralink Foundation INC Baltimore | $20.0M | $20.0M | $16.2M |
| 15 | Association of Community Cancer Centers Rockville | $16.9M | $13.4M | $12.6M |
| 16 | Abilities Network INC Towson | $12.2M | $12.1M | $8.2M |
| 17 | National Tuberous Sclerosis Association INC Silver Spring | $12.0M | $10.0M | $17.3M |
| 18 | Association of Military Surgeons of the U S Gaithersburg | $11.4M | $4.7M | $9.6M |
| 19 | United Needs and Abilities INC Salisbury | $10.7M | $8.0M | $12.9M |
| 20 | University of Maryland Eye Association Pa Baltimore | $9.6M | $9.6M | $3.4M |
| 21 | Transit Employees Retiree Health Fund Forestville | $8.0M | $8.0M | $37.4M |
| 22 | Association of Immunization Managers Rockville | $7.6M | $7.6M | $3.5M |
| 23 | Head Injury Rehabilitation and Referral Services INC Rockville | $5.9M | $5.9M | $6.2M |
| 24 | Curesearch for Childrens Cancer Bethesda | $5.2M | $5.0M | $7.2M |
| 25 | Project Als INC Huntingtown | $4.0M | $3.0M | $1.7M |
| 26 | Hydrocephalus Association Incorporated North Bethesda | $3.9M | $3.6M | $3.5M |
| 27 | Ulman Foundation INC Baltimore | $3.8M | $3.7M | $5.5M |
| 28 | American Society for Colposcopy & Cervical Pathology Clarksburg | $3.6M | $2.9M | $9.4M |
| 29 | Hope Connections for Cancer Support INC Bethesda | $3.0M | $2.7M | $7.4M |
| 30 | Gi Quality Improvement Consortium Ltd N Bethesda | $2.7M | $2.6M | $5.3M |
| 31 | T O U C H Therapy INC Annapolis | $2.6M | $2.6M | $1.6M |
| 32 | Itineris Foundation Baltimore | $2.5M | $972K | $3.9M |
| 33 | National Coalition for Cancer Survivorship Silver Spring | $2.3M | $2.0M | $938K |
| 34 | Cool Kids Campaign Foundation INC Towson | $2.0M | $1.7M | $1.2M |
| 35 | Genetic Alliance INC Damascus | $1.6M | $1.6M | $755K |
| 36 | John W Brick Mental Health Foundation INC Timonium | $1.5M | $1.5M | $307K |
| 37 | National Center for Homoeopathy Clarksburg | $1.5M | $803K | $1.9M |
| 38 | Daydream Sunshine Initiative Bowie | $1.3M | $1.3M | $144K |
| 39 | Digestive Health Physicians Association INC Silver Spring | $1.3M | $1.3M | $997K |
| 40 | Society of Military Orthopaedic Surgeons Towson | $1.2M | $1.2M | $3.3M |
| 41 | Pathfinders INC Hunt Valley | $1.1M | $1.1M | $2.3M |
| 42 | Applied Epi Incorporated Severn | $1.0M | $1.0M | $1.1M |
| 43 | Autism Society of Maryland INC Columbia | $917K | $887K | $646K |
| 44 | Parkinson Foundation of the National Capital Area Olney | $904K | $868K | $4.1M |
| 45 | Deafnet Association INC Hagerstown | $814K | $810K | $2.7M |
| 46 | Diabetes Action Research and Education Foundation Bethesda | $788K | $788K | $717K |
| 47 | Haystack Project INC Severna Park | $759K | $759K | $402K |
| 48 | Breast Cancer Awareness Cumberland Valley INC Hagerstown | $759K | $571K | $1.9M |
| 49 | Pxe International INC Damascus | $680K | $680K | $185K |
| 50 | Esophageal Cancer Action Network INC Pikesville | $633K | $617K | $254K |