| 1 | Vijay R Sanghvi Family Foundation Wilmington | $9.8M | $0 | $10.5M |
| 2 | Autism Delaware INC Newark | $5.4M | $5.3M | $7.1M |
| 3 | Cancer Vaccine Coalition INC Wilmington | $4.2M | $2.1M | $2.1M |
| 4 | Association of Pathology Chairs INC Wilmington | $1.7M | $1.4M | $1.5M |
| 5 | American Society of Cytopathology Wilmington | $1.5M | $1.5M | $2.1M |
| 6 | Incyte Charitable Giving Foundation Wilmington | $1.2M | $0 | $209K |
| 7 | Tova Community Health INC Wilmington | $409K | $409K | $349K |
| 8 | Blindsight Delaware INC Wilmington | $394K | $227K | $2.9M |
| 9 | Beautiful Gate Outreach Center INC Wilmington | $374K | $374K | $136K |
| 10 | Advancing Ctnnb1 Cures and Treatments INC Wilmington | $339K | $336K | $407K |
| 11 | Fallon Family Foundation Wilmington | $293K | $0 | $865K |
| 12 | Epilepsy Foundation of Delaware Newark | $272K | $249K | $489K |
| 13 | Ddx3x Foundation Wilmington | $269K | $269K | $140K |
| 14 | Global Action Network for Sickle Cell & Other Inherited Blood Disor Dover | $259K | $259K | $134K |
| 15 | Transplant Financial Coordinators Association New Castle | $203K | $203K | $203K |
| 16 | William E Proudford Sickle Cell Fund INC Dover | $192K | $187K | $80K |
| 17 | Intersociety Council for Pathology Information INC Wilmington | $159K | $124K | $290K |
| 18 | Justin W Jennings Foundation Ocean View | $128K | $128K | $1.3M |
| 19 | Parkinsons Education & Support Group of Sussex County Lewes | $127K | $127K | $184K |
| 20 | Opennetworks Foundation INC Wilmington | $100K | $100K | $100K |
| 21 | Helen and Dr Arthur Press Foundation for Bronchiectasis Wilmington | $65K | $0 | $307K |
| 22 | Delaware Ovarian Cancer Foundation INC Wilmington | $50K | $42K | $81K |
| 23 | Wilmington-new Castle Pediatric Association Inn Wilmington | $31K | $0 | $221K |
| 24 | Alzheimers Caregivers Association Dover | $1K | $1K | $30K |
| 25 | Jeison Aristizabal Foundation Ltd Camden | $1K | $0 | $1K |
| 26 | Down Syndrome Resource Center INC Milton | $0 | $0 | $0 |
| 27 | Big Ben Shredding Newark | $0 | $0 | $0 |
| 28 | Black-eyed Susans Team Wilmington | $0 | $0 | $0 |
| 29 | Global Blood Disorder Foundation Lewes | $0 | $0 | $0 |
| 30 | World Society for Pediatric Infectious Diseases Wilmington | $0 | $0 | $0 |
| 31 | Kind Giving INC Dover | $0 | $0 | $0 |
| 32 | Dancers Cure Cancer Foundation Hockessin | $0 | $0 | $0 |
| 33 | Gods Good Grace Foundation Millsboro | $0 | $0 | $0 |
| 34 | Rise to Life Foundation Middletown | $0 | $0 | $0 |
| 35 | Phelan Lucky Foundation Wilmington | $0 | $0 | $0 |
| 36 | Save Mickey Association Newark | $0 | $0 | $0 |
| 37 | For Her de Foundation Felton | $0 | $0 | $0 |
| 38 | Sis is Teal INC Newark | $0 | $0 | $0 |
| 39 | Aidens Wish INC Dover | $0 | $0 | $0 |
| 40 | Scouting for a Cure Milford | $0 | $0 | $0 |
| 41 | Delaware Prostate Cancer Coalition Dover | $0 | $0 | $0 |
| 42 | Muscle Movement Foundation Hockessin | $0 | $0 | $0 |
| 43 | Foundation to Cure Retinal Blindness INC Ocean View | $0 | $0 | $0 |
| 44 | Heart in the Game Foundation INC Wilmington | $0 | $0 | $0 |
| 45 | Asclepius Enterprises Ltd Seaford | $0 | $0 | $0 |
| 46 | Down to Box Hockessin | $0 | $0 | $0 |
| 47 | Get Well Map Foundation Milton | $0 | $0 | $0 |
| 48 | Pyramids of Possibilities Newark | $0 | $0 | $0 |
| 49 | Sickle Cell Association of Delaware Wilmington | $0 | $0 | $0 |
| 50 | Nigerian Nurses Association of Delaware and the Delaware Valley Magnolia | $0 | $0 | $0 |