| 1 | Amgen Safety Net Foundation Thousand Oaks | $2.7B | $0 | $723.7M |
| 2 | Dap Health INC Palm Springs | $247.5M | $218.9M | $147.2M |
| 3 | Valley Childrens Medical Group Madera | $162.3M | $162.2M | $89.0M |
| 4 | Cares Community Health Sacramento | $131.8M | $105.0M | $86.2M |
| 5 | Project Angel Food Los Angeles | $81.0M | $24.3M | $62.4M |
| 6 | Pancreatic Cancer Action Network INC El Segundo | $63.1M | $42.2M | $41.0M |
| 7 | Momentum Agencies Chatsworth | $55.6M | $55.6M | $55.5M |
| 8 | Cancer Foundation of Santa Barbara Santa Barbara | $32.6M | $12.0M | $157.5M |
| 9 | United Cerebral Palsy of the North Bay INC Petaluma | $31.1M | $31.1M | $69.6M |
| 10 | Casa Colina Centers for Rehabilitation INC Pomona | $30.8M | $30.8M | $151.8M |
| 11 | United Cerebral Palsy of Greater Saacramento INC Sacramento | $25.8M | $24.9M | $20.0M |
| 12 | American Friends of Sheba Medical Center INC Los Angeles | $24.1M | $23.1M | $22.0M |
| 13 | Asian and Pacific Islander Wellness Center INC San Francisco | $22.5M | $22.1M | $13.4M |
| 14 | Restoringvision San Francisco | $15.7M | $15.7M | $14.3M |
| 15 | Tidepool Project Palo Alto | $14.9M | $14.9M | $15.4M |
| 16 | Mothers2mothers United States INC Los Angeles | $13.7M | $5.9M | $31.9M |
| 17 | Be the Change Foundation INC Saratoga | $12.4M | $250K | $160K |
| 18 | Northern California P E T Imaging Center Sacramento | $12.4M | $10.7M | $12.5M |
| 19 | San Diego Lesbian Gay Bisexual and Transgender Community Center San Diego | $12.3M | $11.6M | $32.7M |
| 20 | Alzheimers Greater Los Angeles Los Angeles | $11.7M | $7.1M | $12.6M |
| 21 | United Cerebral Palsy Association of Central California INC Fresno | $11.5M | $11.4M | $15.8M |
| 22 | N-lorem Foundation Carlsbad | $11.0M | $11.0M | $12.3M |
| 23 | Foundation for Prader Willi Research Covina | $10.4M | $6.2M | $8.9M |
| 24 | Granite Wellness Centers Roseville | $10.3M | $10.2M | $16.6M |
| 25 | Society for the Blind Sacramento | $9.3M | $4.5M | $8.7M |
| 26 | Asian & Pacific Islander American Health Forum San Francisco | $9.0M | $5.4M | $17.3M |
| 27 | United Cerebral Palsy of the Inland Empire Palm Desert | $8.7M | $6.0M | $9.7M |
| 28 | United Cerebral Palsy Association Stockton | $8.3M | $8.3M | $15.5M |
| 29 | United Cerebral Palsy Association of Orange County INC Santa Ana | $8.1M | $8.1M | $8.2M |
| 30 | Alzheimers Orange County Irvine | $7.9M | $7.7M | $5.8M |
| 31 | John Wayne Cancer Foundation Costa Mesa | $7.8M | $2.3M | $20.3M |
| 32 | California Autism Foundation Richmond | $7.7M | $6.3M | $11.7M |
| 33 | San Diego Biomedical Research Institute San Diego | $7.6M | $7.6M | $15.7M |
| 34 | Cancer for College San Diego | $7.4M | $4.2M | $18.2M |
| 35 | Ahf McO of Florida INC Los Angeles | $7.4M | $5.1M | $23.4M |
| 36 | Central California Asthma Collaborative Fresno | $7.4M | $7.4M | $3.7M |
| 37 | Rafiki Coalition for Health and Wellness San Francisco | $7.1M | $7.1M | $7.6M |
| 38 | Proteogenomics Research Institute for Systems Medicine San Diego | $6.8M | $6.8M | $1.1M |
| 39 | Curebound INC San Diego | $6.4M | $5.5M | $16.4M |
| 40 | Jessie Rees Foundation Rcho Sta Marg | $5.8M | $4.7M | $3.7M |
| 41 | Project New Hope Glendale | $5.4M | $5.4M | $11.5M |
| 42 | Mary Valle Foundation for the Cerebral Palsied Oakland | $5.4M | $793K | $21.0M |
| 43 | Norcal Services for Deaf and Hard of Hearing Sacramento | $5.3M | $5.3M | $3.6M |
| 44 | Hilarity for Charity Los Angeles | $5.1M | $4.7M | $3.0M |
| 45 | Wall-las Memorias Project Los Angeles | $4.9M | $4.9M | $4.3M |
| 46 | Celiac Disease Foundation Woodland Hls | $4.7M | $4.3M | $7.6M |
| 47 | Deaf Community Services of San Diego INC National City | $4.4M | $4.4M | $3.8M |
| 48 | Dermatology Education Foundation San Jose | $4.4M | $4.4M | $2.9M |
| 49 | Bay Area Cancer Connections San Mateo | $4.2M | $4.2M | $5.4M |
| 50 | Vista Center for the Blind and Visually Impaired Palo Alto | $4.1M | $3.9M | $12.8M |