| 1 | Charleston Area Convention & Visitors Bureau Charleston | $32.7M | $32.3M | $23.2M |
| 2 | Waccamaw Economic Opportunity Council INC Conway | $17.0M | $16.9M | $8.1M |
| 3 | Greater Lake City Alliance Lake City | $14.6M | $13.8M | $94.8M |
| 4 | South Carolina Manufacturing Extension Partnership Greenville | $14.5M | $9.3M | $5.4M |
| 5 | Southern Carolina Regional Development Alliance Hampton | $12.4M | $12.4M | $41.7M |
| 6 | Seabrook Island Property Owners Association Johns Island | $12.3M | $12.3M | $21.9M |
| 7 | Advanced Technology International Foundation Summerville | $11.7M | $11.7M | $12.6M |
| 8 | United Housing Connections Greenville | $11.3M | $11.3M | $21.5M |
| 9 | Ocab INC Community Action Agency Orangeburg | $10.8M | $10.8M | $7.4M |
| 10 | Greenwood County Community Foundation INC Greenwood | $9.1M | $2.9M | $26.7M |
| 11 | South Carolina Dealer Services LLC Columbia | $8.8M | $4.6M | $3.8M |
| 12 | Columbia Empowerment Zone INC Columbia | $8.6M | $1.8M | $12.9M |
| 13 | Waccamaw Community Foundation INC Murrells Inlt | $8.6M | $5.6M | $38.4M |
| 14 | Opportunity South Carolina Greenville | $7.7M | $7.7M | $86.0M |
| 15 | Lowcountry Community Action Agency 807 Hampton Walterboro | $7.5M | $7.5M | $2.6M |
| 16 | Catawba Regional Council of Governments Rock Hill | $7.0M | $7.0M | $21.8M |
| 17 | Southeast Coastal Ocean Observing Regional Association Charleston | $6.6M | $6.6M | $2.6M |
| 18 | Investsc INC Columbia | $6.3M | $3.4M | $30.4M |
| 19 | Climb Fund Charleston | $5.0M | $3.4M | $38.5M |
| 20 | New Capernaum Life Services Columbia | $4.7M | $4.7M | $4.4M |
| 21 | North Myrtle Beach Chamber of Commerce INC N Myrtle Bch | $4.1M | $4.1M | $4.6M |
| 22 | Srs Community Reuse Organization Aiken | $3.9M | $3.9M | $6.6M |
| 23 | Metanoia N Charleston | $3.8M | $3.8M | $27.1M |
| 24 | Charleston Redevelopment Corporation Charleston | $3.7M | $3.0M | $21.5M |
| 25 | Lead-chs Foundation N Charleston | $3.7M | $3.7M | $1.0M |
| 26 | Friends of the Edisto INC N Charleston | $3.6M | $99K | $283K |
| 27 | Chester Facilities Corporation Chester | $3.5M | $3.5M | $29.1M |
| 28 | Coastal Community Development Corporation Hilton Head | $3.4M | $3.4M | $9.0M |
| 29 | Upstate South Carolina Alliance INC Greenville | $3.2M | $3.2M | $3.5M |
| 30 | North Eastern Stragetic Alliance INC Florence | $3.0M | $3.0M | $1.2M |
| 31 | Building Forence Together Cdc Florence | $2.7M | $2.6M | $3.3M |
| 32 | Columbia Facilities Corporation Columbia | $2.7M | $2.7M | $49.8M |
| 33 | Greenville Area Development Corporation Greenville | $2.7M | $2.7M | $2.9M |
| 34 | Council of Autism Service Providers Lexington | $2.6M | $2.6M | $1.3M |
| 35 | Church Mouse Thrift Shop INC Hilton Head | $2.5M | $2.5M | $1.3M |
| 36 | Beta Zeta House Corporation Columbia | $2.5M | $1.5M | $6.1M |
| 37 | Charleston Digital Corridor Foundation Charleston | $2.4M | $2.4M | $5.0M |
| 38 | City of Florence Public Facilities Corporation Florence | $2.4M | $2.4M | $4.2M |
| 39 | Georgetown County Chamber of Georgetown | $2.4M | $2.4M | $2.0M |
| 40 | South Carolina Arms Collectors Assoc INC Leesville | $2.3M | $1.5M | $2.4M |
| 41 | International Transportation Innovation Center Greenville | $2.2M | $2.2M | $15.9M |
| 42 | Northside Development Corporation Spartanburg | $2.2M | $2.1M | $27.4M |
| 43 | Central Carolina Economic Development Alliance Columbia | $2.2M | $2.1M | $4.0M |
| 44 | Seneca Improvements Corporation Seneca | $2.1M | $2.1M | $8.2M |
| 45 | Daniel Island Community Fund INC Daniel Island | $2.1M | $2.1M | $3.6M |
| 46 | South Carolina Association for Community Economic Development Charleston | $2.1M | $2.1M | $2.1M |
| 47 | South Carolina Council on Competitiveness Columbia | $2.0M | $2.0M | $3.2M |
| 48 | South Carolina I-77 Alliance Richburg | $1.9M | $1.9M | $4.8M |
| 49 | City Center Partnership INC Columbia | $1.9M | $1.9M | $1.2M |
| 50 | University Center Facilities Corporation III Rock Hill | $1.7M | $1.7M | $18.0M |