| 1 | Peace Center Foundation Greenville | $51.1M | $50.5M | $151.5M |
| 2 | Etv Endowment of South Carolina INC Spartanburg | $21.9M | $14.6M | $41.8M |
| 3 | Spoleto Festival U S a Charleston | $11.8M | $11.2M | $20.5M |
| 4 | International African American Museum Charleston | $11.2M | $11.2M | $73.5M |
| 5 | Charleston Gaillard Management Corporation Charleston | $11.0M | $11.0M | $8.3M |
| 6 | Pennell Family Foundation Greenville | $9.7M | $0 | $12.2M |
| 7 | Carolina Art Association Charleston | $8.5M | $5.3M | $19.8M |
| 8 | National Educational Telecommunications Association Columbia | $6.7M | $6.7M | $3.1M |
| 9 | Edventure INC Columbia | $6.6M | $6.3M | $9.9M |
| 10 | Cultural and Heritage Commission of York County York | $6.5M | $6.4M | $7.6M |
| 11 | Columbia Museum of Art Columbia | $5.7M | $5.6M | $21.3M |
| 12 | Arts Center of Coastal Carolina Hilton Head | $5.2M | $5.1M | $8.1M |
| 13 | Charleston Symphony Orchestra Charleston | $5.1M | $5.1M | $10.7M |
| 14 | Greenville Symphony Endowment Fund INC Greenville | $5.1M | $663K | $13.1M |
| 15 | Newberry Opera House Foundation INC Newberry | $4.7M | $3.3M | $6.4M |
| 16 | Childrens Museum of the Upstate INC Greenville | $4.4M | $4.4M | $30.6M |
| 17 | South Carolina Historical Society Charleston | $4.3M | $3.0M | $11.2M |
| 18 | Charleston Museum Charleston | $4.0M | $3.8M | $24.5M |
| 19 | Chapman Cultural Center INC Spartanburg | $3.9M | $3.9M | $31.3M |
| 20 | Sumter Museum Sumter | $3.8M | $3.7M | $7.0M |
| 21 | Historic Columbia Foundation INC Columbia | $3.7M | $3.1M | $4.3M |
| 22 | Charleston Stage Company Charleston | $3.7M | $3.7M | $1.6M |
| 23 | Greenville Symphony Association Greenville | $3.6M | $3.6M | $2.6M |
| 24 | Medal of Honor Foundation INC Mt Pleasant | $3.6M | $2.5M | $5.7M |
| 25 | South Carolina State Museum Foundation Columbia | $3.4M | $1.9M | $6.4M |
| 26 | Martha and John M Rivers Performance Hall Foundation Charleston | $3.3M | $3.3M | $13.3M |
| 27 | Middleton Place Foundation Charleston | $2.8M | $2.8M | $39.9M |
| 28 | Lake City Creative Alliance Lake City | $2.8M | $2.8M | $2.2M |
| 29 | Hilton Head Symphony Orchestra INC Hilton Head | $2.7M | $2.6M | $2.4M |
| 30 | South Carolina Educational Communications INC Spartanburg | $2.5M | $2.5M | $681K |
| 31 | South Carolina Ballet INC Columbia | $2.4M | $2.3M | $770K |
| 32 | Bill McDaniels Foundation Elgin | $2.4M | $0 | $6.0M |
| 33 | Childrens Museum of the Lowcountry Charleston | $2.3M | $2.3M | $4.8M |
| 34 | Greenville Arts Festival Greenville | $2.3M | $2.3M | $808K |
| 35 | Coastal Discovery Museum Hilton Head | $2.0M | $1.9M | $9.2M |
| 36 | Association for Education in Journalism and Mass Communication Columbia | $1.9M | $1.9M | $2.6M |
| 37 | South Carolina Philharmonic INC Columbia | $1.9M | $1.9M | $1.4M |
| 38 | Greenville Theatre Greenville | $1.8M | $1.8M | $1.3M |
| 39 | Charleston Literary Festival INC Charleston | $1.7M | $1.7M | $926K |
| 40 | Arts Center of Kershaw County INC Camden | $1.7M | $1.2M | $3.2M |
| 41 | Dorchester Heritage Center INC Saint George | $1.7M | $1.7M | $3.7M |
| 42 | South Carolina Childrens Theatre Greenville | $1.6M | $1.6M | $13.6M |
| 43 | Hagood Mill Foundation Pickens | $1.5M | $1.5M | $1.1M |
| 44 | Historic Mitchelville Freedom Park INC Hilton Head | $1.5M | $1.4M | $7.9M |
| 45 | Upstate Preservation Trust Greenville | $1.5M | $1.5M | $250K |
| 46 | Charleston Jazz N Charleston | $1.4M | $1.4M | $765K |
| 47 | Driving Force Institute for Public Engagement INC Florence | $1.4M | $1.4M | $538K |
| 48 | Theatre of the Republic INC Conway | $1.4M | $1.4M | $1.3M |
| 49 | International Ballet Greer | $1.4M | $1.3M | $397K |
| 50 | Hilton Head Island Concours D Elegance INC Hilton Head | $1.3M | $1.3M | $163K |