| 1 | South Carolina Aquarium Charleston | $41.0M | $20.3M | $50.9M |
| 2 | Aiken Horse Park Foundation Aiken | $17.0M | $0 | $27.4M |
| 3 | Charleston Animal Society N Charleston | $15.9M | $11.9M | $33.7M |
| 4 | Riverbanks Society Columbia | $13.9M | $13.8M | $17.0M |
| 5 | Nemours Plantation Wildlife Foundation Yemassee | $9.8M | $0 | $49.5M |
| 6 | South Carolina Society for the Prevention of Cruelty to Animals Greenville | $9.6M | $9.5M | $15.8M |
| 7 | Pawmettolifeline INC Columbia | $8.5M | $7.5M | $10.5M |
| 8 | Interlaken Wildlife Foundation Cameron | $6.4M | $0 | $6.3M |
| 9 | Hallie Hill Animal Sanctuary Hollywood | $4.2M | $1.5M | $6.2M |
| 10 | Danny and Rons Rescue Rembert | $4.2M | $4.0M | $4.5M |
| 11 | Darlington County Humane Society INC Hartsville | $4.0M | $4.0M | $10.5M |
| 12 | Turtle Survival Alliance N Charleston | $3.8M | $3.8M | $16.6M |
| 13 | Dorchester Paws Summerville | $3.7M | $3.4M | $5.3M |
| 14 | Hilton Head Humane Association INC Hilton Head | $3.5M | $3.5M | $12.1M |
| 15 | Pets INC of the Midlands Lexington | $3.3M | $2.9M | $1.8M |
| 16 | International Primate Protection League Summerville | $3.3M | $2.2M | $10.4M |
| 17 | SPCA Albrecht Center for Animal Welfare Aiken | $3.2M | $2.7M | $8.2M |
| 18 | World Parrot Trust USA INC Travelers Rst | $2.7M | $1.7M | $2.5M |
| 19 | Pet Helpers INC N Charleston | $2.6M | $2.4M | $7.9M |
| 20 | Humane Society for the Prevention Columbia | $2.5M | $2.5M | $3.9M |
| 21 | Grand Strand Humane Society INC Myrtle Beach | $2.3M | $2.2M | $2.3M |
| 22 | Animal Protection League of South Carolina West Columbia | $2.3M | $2.3M | $3.2M |
| 23 | Humane Net INC N Charleston | $2.0M | $33K | $71K |
| 24 | Animal Allies Spartanburg | $1.9M | $1.9M | $1.1M |
| 25 | All 4 Paws Pawleys Isl | $1.7M | $1.5M | $1.1M |
| 26 | Friends of the Greenville Zoo INC Greenville | $1.7M | $1.6M | $1.9M |
| 27 | Avian Conservation Center Awendaw | $1.5M | $1.4M | $5.9M |
| 28 | Carolina Poodle Rescue Pacolet | $1.4M | $1.4M | $842K |
| 29 | Oconee County Humane Society INC Seneca | $1.4M | $1.3M | $1.8M |
| 30 | Concerned Citzens for Animals Simpsonville | $1.4M | $358K | $4.3M |
| 31 | York County Humane Society Fort Mill | $1.4M | $1.4M | $4.1M |
| 32 | Saint Frances Animal Center Georgetown | $1.3M | $1.3M | $2.2M |
| 33 | Friends of the Animal Shelter INC Aiken | $1.3M | $1.2M | $3.9M |
| 34 | Society for the Prevention of Cruelty to Animals & Humane Sumter | $1.2M | $800K | $4.0M |
| 35 | Humane Society of Greenwood Greenwood | $1.2M | $1.1M | $1.9M |
| 36 | Kind Keeper INC North Myrtle Beach | $1.1M | $1.1M | $1.1M |
| 37 | Equine Rescue of Aiken Aiken | $1.1M | $1.0M | $1.8M |
| 38 | Kershaw County Humane Society Camden | $1.1M | $1.0M | $2.0M |
| 39 | Snipwell Spay Neuter & Wellness Clinic INC Fort Mill | $1.0M | $1.0M | $287K |
| 40 | The Humane Society of North Myrtle Beach INC North Myrtle Beach | $995K | $981K | $1.5M |
| 41 | Last Chance Animal Rescue Fund Carlisle | $924K | $872K | $480K |
| 42 | Noahs Arks Rescue Okatie | $830K | $627K | $1.8M |
| 43 | Www Pilotsnpaws Org Incorporated Landrum | $758K | $757K | $3.5M |
| 44 | Florence Area Humane Society Florence | $745K | $454K | $2.4M |
| 45 | Boykin Spaniel Rescue Boiling Spgs | $708K | $665K | $535K |
| 46 | Magnolia Fawn Rescue INC Gray Court | $693K | $0 | $5K |
| 47 | Fostering Foster Animal Rescue Camden | $667K | $666K | $635K |
| 48 | Animal Mission Columbia | $666K | $527K | $957K |
| 49 | South Carolina Wildlife Federation Columbia | $638K | $537K | $1.0M |
| 50 | Jasper Animal Rescue Mission Ridgeland | $593K | $593K | $109K |