| 1 | Indianapolis Zoological Society INC Indianapolis | $63.7M | $57.7M | $245.4M |
| 2 | Fort Wayne Zoological Society INC Fort Wayne | $28.7M | $18.2M | $40.1M |
| 3 | Humane Society of Indianapolis INC Indianapolis | $8.5M | $8.4M | $4.5M |
| 4 | Potawatomi Zoological Society INC South Bend | $8.4M | $7.8M | $6.6M |
| 5 | Humane Fort Wayne INC Fort Wayne | $7.7M | $7.0M | $18.2M |
| 6 | Low Cost Spay-neuter Clinic INC Noblesville | $6.9M | $6.1M | $9.1M |
| 7 | The Humane Society of Elkhart County Incorporated Bristol | $6.7M | $4.8M | $10.3M |
| 8 | Humane Society for Hamilton County INC Fishers | $5.7M | $5.3M | $19.9M |
| 9 | Sanda Hills Equine Center INC Jasper | $5.7M | $0 | $105.8M |
| 10 | Foundation Against Companion Animal Euthanasia INC Indianapolis | $4.6M | $4.5M | $3.8M |
| 11 | Pet Refuge INC South Bend | $3.2M | $2.3M | $4.6M |
| 12 | Vanderburgh County Humane Society INC Evansville | $3.2M | $2.9M | $3.3M |
| 13 | Michiana Humane Society INC Michigan City | $2.9M | $2.2M | $7.2M |
| 14 | Peaceable Primate Santuary Winamac | $2.8M | $2.0M | $2.7M |
| 15 | Friends of Indianapolis Animal Care & Control Foundation INC Indianapolis | $2.7M | $2.6M | $5.6M |
| 16 | Humane Indiana INC Munster | $2.6M | $2.5M | $10.9M |
| 17 | Greene County Humane Society INC Linton | $2.5M | $604K | $4.4M |
| 18 | Mary Powell Crum Tr Indianapolis | $2.2M | $392K | $7.0M |
| 19 | Bill Simpson Foundation Brownsburg | $2.0M | $0 | $18.4M |
| 20 | Sylvan Lake Improvement Association Rome City | $1.8M | $117K | $1.6M |
| 21 | Public Vet Bloomington | $1.7M | $1.7M | $144K |
| 22 | Bloomington Pets Alive INC Bloomington | $1.7M | $1.7M | $375K |
| 23 | The Leatherback Trust INC Fort Wayne | $1.6M | $1.6M | $4.2M |
| 24 | Morgan County Humane Society INC Martinsville | $1.6M | $1.6M | $1.3M |
| 25 | Kokomo Humane Society Kokomo | $1.5M | $1.4M | $5.1M |
| 26 | Exotic Feline Rescue Center INC Centerpoint | $1.4M | $1.4M | $2.0M |
| 27 | Spay-neuter Services INC Indianapolis | $1.4M | $1.3M | $478K |
| 28 | Professional Animal Retirement Center Albion | $1.4M | $1.3M | $1.1M |
| 29 | Love Pet Project INC Zionsville | $1.3M | $1.3M | $395K |
| 30 | Humane Society of Hobart INC Hobart | $1.3M | $1.3M | $559K |
| 31 | Terre Haute Humane Society Terre Haute | $1.3M | $1.2M | $4.4M |
| 32 | Evansville Zoological Society INC Evansville | $1.2M | $1.0M | $3.0M |
| 33 | Animals Rescue Fund INC Muncie | $1.2M | $1.1M | $1.8M |
| 34 | Brown County Humane Society INC Nashville | $1.1M | $1.1M | $8.5M |
| 35 | Huntington County Humane Society INC Huntington | $1.1M | $1.1M | $1.1M |
| 36 | Humane Association INC of Monroe County Bloomington | $1.1M | $1.1M | $3.8M |
| 37 | Warrick Humane Society INC Newburgh | $1.1M | $879K | $1.5M |
| 38 | Animal Protection League INC Anderson | $978K | $971K | $90K |
| 39 | Partners for Animal Welfare Society of Dearborn County INC Lawrenceburg | $971K | $645K | $2.4M |
| 40 | Four Precious Paws Low Cost Spay & Neuter Clinic INC Lafayette | $933K | $933K | $51K |
| 41 | It Takes a Village Canine Rescue Evansville | $912K | $912K | $261K |
| 42 | Frieds Cat Shelter INC Michigan City | $877K | $877K | $1.4M |
| 43 | Pipsqueakery INC Bloomington | $837K | $767K | $247K |
| 44 | Lc Nature Park INC Roanoke | $831K | $770K | $5.8M |
| 45 | Almost Home Humane Society INC Lafayette | $817K | $816K | $2.1M |
| 46 | Medical Mutts Service Dogs INC Indianapolis | $814K | $793K | $173K |
| 47 | Animal Care Alliance Company Richmond | $793K | $793K | $489K |
| 48 | Rosies Southside Animal Shelter INC Indianapolis | $772K | $770K | $1.0M |
| 49 | Resale to the Rescue INC Mishawaka | $768K | $560K | $121K |
| 50 | Dekalb Humane Society INC Auburn | $710K | $703K | $2.3M |