| 1 | Lincoln Park Zoological Society Chicago | $239.9M | $50.5M | $254.0M |
| 2 | Shedd Aquarium Society Chicago | $218.0M | $102.0M | $780.1M |
| 3 | Chicago Zoological Society Brookfield | $117.6M | $108.0M | $317.2M |
| 4 | Paws Chicago Chicago | $96.1M | $47.0M | $150.1M |
| 5 | Anti-cruelty Society Chicago | $47.7M | $14.0M | $58.1M |
| 6 | Brooks McCormick Jr Tr for Animal Rights Law and Policy Downers Grove | $14.9M | $0 | $49.1M |
| 7 | National Anti-vivisection Society Chicago | $14.5M | $4.6M | $28.0M |
| 8 | Kobe Foundation INC Northbrook | $10.4M | $0 | $22.3M |
| 9 | Orphans of the Storm Deerfield | $6.8M | $6.1M | $10.7M |
| 10 | Anderson Animal Shelter South Elgin | $6.2M | $5.1M | $4.0M |
| 11 | American College of Veterinary Pathologists Schaumburg | $6.1M | $1.8M | $7.8M |
| 12 | Animal Protective League of Springfield and Sangamon County Springfield | $6.1M | $5.3M | $13.6M |
| 13 | Tree House Humane Society Chicago | $5.5M | $5.4M | $11.1M |
| 14 | American Veterinary Medical Foundation Schaumburg | $5.1M | $3.9M | $12.4M |
| 15 | One Tail at a Time Nfp Chicago | $5.0M | $4.8M | $2.5M |
| 16 | South Suburban Humane Society Matteson | $4.9M | $4.8M | $10.4M |
| 17 | Save a Pet INC Grayslake | $4.8M | $3.4M | $10.0M |
| 18 | Animal Welfare League Chicago Ridge | $4.7M | $4.2M | $20.7M |
| 19 | Spay Illinois Pet Well Clinics INC Naperville | $4.4M | $3.6M | $6.1M |
| 20 | Champaign County Humane Society INC Champaign | $3.4M | $3.4M | $17.7M |
| 21 | Gateway Pet Guardians E Saint Louis | $2.9M | $2.7M | $1.6M |
| 22 | Wright-way Rescue Morton Grove | $2.8M | $2.8M | $2.0M |
| 23 | Peoples Animal Welfare Society Tinley Park | $2.4M | $1.4M | $4.4M |
| 24 | Knox County Humane Society Galesburg | $2.3M | $2.3M | $6.0M |
| 25 | Humane Society of Rock Island County Milan | $2.2M | $2.2M | $8.4M |
| 26 | Showing Animals Respect and Kindness INC Geneva | $2.1M | $2.1M | $2.1M |
| 27 | Area 51 Sanctuary INC Schaumburg | $2.1M | $0 | $1.5M |
| 28 | Animal House Shelter INC Huntley | $2.1M | $2.1M | $4.4M |
| 29 | Hinsdale Humane Society Hinsdale | $2.1M | $2.0M | $5.4M |
| 30 | Just Animals Placement Service Mazon | $2.0M | $2.0M | $1.9M |
| 31 | National Animal Welfare Society INC Orland Park | $2.0M | $2.0M | $213K |
| 32 | Animal Care League Oak Park | $2.0M | $1.8M | $7.6M |
| 33 | Tazewell Animal Protective Society Pekin | $1.9M | $1.9M | $4.1M |
| 34 | Midwest Furry Fandom Rosemont | $1.9M | $1.9M | $1.2M |
| 35 | Henry County Humane Society Kewanee Chapter Kewanee | $1.8M | $1.8M | $1.9M |
| 36 | George F and Helen M Hirschmann Charitable Foundation Rolling Meadows | $1.7M | $0 | $3.5M |
| 37 | Mission Compassion Paw INC Chicago | $1.7M | $979K | $1.1M |
| 38 | Ivar and Ruth Anderson Anti Cruelty Trust Elgin | $1.7M | $0 | $5.0M |
| 39 | Belleville Area Humane Society Belleville | $1.7M | $1.6M | $2.1M |
| 40 | Tails Humane Society Dekalb | $1.6M | $1.6M | $3.2M |
| 41 | Everett and Rosemarie Brown Family Foundation 02-50467 Chicago | $1.6M | $299K | $5.8M |
| 42 | Felines INC Chicago | $1.6M | $1.6M | $3.2M |
| 43 | Border Tails Rescue Northbrook | $1.5M | $1.5M | $72K |
| 44 | Tender Loving Care Animal Shelter Homer Glen | $1.4M | $1.3M | $3.1M |
| 45 | Young at Heart Pet Rescue INC Woodstock | $1.4M | $1.3M | $2.2M |
| 46 | Humane Society of Southern Illinois/spca INC Carbondale | $1.4M | $1.3M | $1.2M |
| 47 | Heartland Animal Shelter Nfp Wheeling | $1.3M | $1.3M | $2.3M |
| 48 | Robert E Ahlf Preserve Fund Nfp P Chicago | $1.3M | $329K | $7.5M |
| 49 | West Suburban Humane Society Downers Grove | $1.3M | $1.3M | $6.0M |
| 50 | Naperville Area Humane Society INC Naperville | $1.3M | $1.0M | $4.3M |